1. Transplantation of De Novo Scaffold-Free Cartilage Implants Into Sheep Knee Chondral Defects.
- Author
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Jubel, Axel, Andermahr, Jonas, Schiffer, Gereon, Fischer, Jürgen, Rehm, Klaus E., Stoddart, Martin J., and Häuselmann, Hans J.
- Subjects
TRANSPLANTATION of organs, tissues, etc. ,CARTILAGE cells ,KNEE abnormalities ,REGENERATION (Biology) ,TISSUES ,AUTOGRAFTS ,ARTICULAR cartilage ,SHEEP as laboratory animals ,AUTOTRANSPLANTATION ,THERAPEUTICS - Abstract
The article presents a study on the repair of articular cartilage. Transplantation of chondrocyte experiments on sheep reveals a qualitatively better regenerative tissue compared to periosteal flap and no treatment. Some sheeps were treated with periosteal while other were treated with periosteal and filled with autologous de novo cartilage graft. The result shows that the implanted group has a remarkable improvement in grade of defect filling, cartilage stability and cell distribution. It further shows that de novo cartilage transplantation for chondral defects has a better qualitative microscopic and macroscopic regeneration compared to other treatment.
- Published
- 2008
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