1. Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains.
- Author
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Khalid A, Ahmad P, Alharthi AI, Muhammad S, Khandaker MU, Faruque MRI, Din IU, Alotaibi MA, and Khan A
- Subjects
- Copper chemistry, Copper pharmacology, Drug Resistance, Multiple, Bacterial drug effects, Escherichia coli isolation & purification, Humans, Klebsiella pneumoniae isolation & purification, Metal Nanoparticles chemistry, Microbial Sensitivity Tests, Staphylococcus aureus isolation & purification, Streptococcus pyogenes isolation & purification, Anti-Bacterial Agents pharmacology, Escherichia coli drug effects, Klebsiella pneumoniae drug effects, Staphylococcus aureus drug effects, Streptococcus pyogenes drug effects, Zinc Oxide pharmacology
- Abstract
A viable hydrothermal technique has been explored for the synthesis of copper doped Zinc oxide nanoparticles (Cu-doped ZnO-NPs) based on the precursor's mixture of Copper-II chloride dihydrate (CuCl2.2H2O), Zinc chloride (ZnCl2), and potassium hydroxide (KOH). X-ray diffraction (XRD) reported the hexagonal wurtzite structure of the synthesized Cu-doped ZnO-NPs. The surface morphology is checked via field emission scanning electron microscopy (FE-SEM), whereas, the elemental compositions of the samples were confirmed by Raman, and X-ray photoelectron spectroscopy (XPS), respectively. The as-obtained ZnO-NPs and Cu-doped ZnO-NPs were then tested for their antibacterial activity against clinical isolates of Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Klebsiella pneumonia) bacteria via agar well diffusion method. The zone of inhibition (ZOI) for Cu-doped ZnO-NPs was found to be 24 and 19 mm against S. Aureus and S. pyogenes, and 18 and 11 mm against E. coli and K. pneumoniae, respectively. The synthesized Cu-doped ZnO-NPs can thus be found as a potential nano antibiotic against Gram-positive multi-drug resistant bacterial strains., Competing Interests: I have read the journal’s policy and the authors of this manuscript have no competing interests.
- Published
- 2021
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