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Natural killer (NK)-based immunotherapeutic strategies are showing promise in the clinic, particularly against acute myeloid leukemia (AML). Similar treatments for T-cell acute lymphoblastic leukemia (T-ALL) have been less successful, which is due to the higher resistance of T-ALL blasts to the cytotoxic function of NK cells. Herein, microRNA-29b (miR-29b) upregulation was identified in NK cells in both neurogenic locus notch homolog protein 1 (Notch1)-T-ALL mice and patients with T-ALL. Furthermore, miR-29b expression levels were downregulated in T-ALL blast cells. In addition, there was a selective downregulation of an immature subset of NK cells, as well as a reduction in interferon γ (IFNγ) production and natural killer receptor group 2, member D (NKG2D) expression level by NK cells in Notch1-T-ALL mice and patients with T-ALL. Furthermore, when miR-29b knock-out NK cells were adoptively transfused into Notch1-T-ALL mice, partial restoration of IFNγ production and NKG2D expression was observed in NK cells, accompanied by retarded ALL progression and improved survival time. These results implied that T-ALL blast immune evasion occurred via miR-29b-mediated dysregulation in NK cells in the T-ALL microenvironment. [ABSTRACT FROM AUTHOR]

Oncol Lett 18: 2394-2403, 2019; DOI: 10.3892/ol.2019.10559 Following the publication of this article, the authors have realized that a couple of errors went unnoticed in the text. These are explained as follows (changes to the printed text are highlighted in bold): In the "Statistical analysis" section, on p. 2396, the 7 SP th sp line, it was incorrectly stated that the RT-qPCR data were analyzed using SPSS 12.0 (SPSS, Inc.); in fact, Prism 5 (GraphPad Software, Inc.) was also used for the statistical treatment of these data. Therefore, the sentence here in its entirety should have read as: "The flow cytometry results were analyzed using FlowJo 10.0.7 software (FlowJo LLC), and the RT-qPCR data was analyzed using B Prism 5 (GraphPad Software, Inc.) b " This error does not affect the results in any way. [Extracted from the article]