1. The adaptive and innate immune systems coordinate for successful control of CMV infection.
- Author
-
Schaenman JM
- Subjects
- Humans, Immunity, Cellular, Natural Killer T-Cells immunology, Cytomegalovirus Infections immunology, Cytomegalovirus Infections prevention & control, Immunity, Innate, Adaptive Immunity, Kidney Transplantation adverse effects, Cytomegalovirus immunology
- Abstract
Previous studies of the immune control of cytomegalovirus infection have primarily focused on analysis of the traditional adaptive T-cell response. Donadeu et al. bring a new perspective through evaluation of multiple adaptive and innate immune subtypes in parallel with cytomegalovirus-specific cell-mediated immunity in a prospective cohort of kidney transplant recipients with findings validated in 2 independent studies. Identification of a natural killer T-cell subtype associated with cell-mediated immunity and freedom from cytomegalovirus infection demonstrates the importance of the coordinated innate and adaptive immune response for effective viral control., (Copyright © 2024 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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