1. Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice.
- Author
-
El-Said KS, Hussein S, Alrashdi BM, Mahmoud HA, Ibrahim MA, Elbakry M, El-Tantawy H, Kabil DI, and El-Naggar SA
- Subjects
- Animals, Antioxidants chemistry, Antioxidants therapeutic use, Blood Cell Count, Cadmium toxicity, Cadmium Poisoning prevention & control, Chelating Agents chemistry, Chelating Agents therapeutic use, Chemical and Drug Induced Liver Injury blood, Chemical and Drug Induced Liver Injury pathology, Cyclooxygenase 1 genetics, Cyclooxygenase 1 metabolism, Enzymes metabolism, Kidney Diseases blood, Kidney Diseases chemically induced, Kidney Diseases pathology, Lethal Dose 50, Male, Membrane Proteins genetics, Membrane Proteins metabolism, Mice, NF-kappa B genetics, NF-kappa B metabolism, Oxidative Stress drug effects, Plant Extracts chemistry, Plant Extracts therapeutic use, Transforming Growth Factor beta1 genetics, Transforming Growth Factor beta1 metabolism, Antioxidants pharmacology, Chelating Agents pharmacology, Chemical and Drug Induced Liver Injury prevention & control, Kidney Diseases prevention & control, Musa chemistry, Plant Extracts pharmacology, Plant Leaves chemistry
- Abstract
Heavy metals intoxication causes several health problems that necessitate finding new protective and therapeutic approaches. This study aimed to evaluate the impact of Musa sp. leaves extract (MLE) on hepato-renal toxicities induced by cadmium (Cd) in male mice. The phytochemical screening, metal chelating activity (MCA), and the median lethal dose (LD
50 ) of MLE were determined. Fifty CD-1 male mice were used and intraperitoneally (i.p.) injected with MLE (1000 to 5000 mg/kg b.wt) for MLE LD50 determination. Another 50 mice were used for evaluating the effect of MLE on Cd toxicity. Blood samples were collected for hematological, liver, and kidney functions assessments. Liver tissue homogenates were used for determination of oxidant/antioxidant parameters. Liver and kidney tissues were harvested for histopathological and molecular investigations. MLE showed potent in vitro antioxidant activities. The MCA and LD50 of the MLE were 75 µg/mL and 3000 mg/kg b.wt, respectively. MLE showed beneficial therapeutic activity against hepato-renal toxicities in Cd-intoxicated mice, evidenced by improving the hematological, biochemical, histopathological, and molecular alterations.- Published
- 2022
- Full Text
- View/download PDF