Search

Your search keyword '"Gusmano, R"' showing total 15 results
Start Over Author "Gusmano, R" Topic kidney diseases
15 results on '"Gusmano, R"'

1. Mesenchymal stem cells protective effect in adriamycin model of nephropathy.

Author

Magnasco A, Corselli M, Bertelli R, Ibatici A, Peresi M, Gaggero G, Cappiello V, Chiavarina B, Mattioli G, Gusmano R, Ravetti JL, Frassoni F, and Ghiggeri GM

Subjects
Animals, Antibiotics, Antineoplastic, Cell Movement physiology, Cells, Cultured, Chronic Disease, Cytoprotection physiology, Humans, Kidney Diseases pathology, Male, Mesenchymal Stem Cell Transplantation, Podocytes drug effects, Podocytes physiology, Rats, Disease Models, Animal, Doxorubicin, Kidney Diseases chemically induced, Kidney Diseases therapy, Mesenchymal Stem Cells physiology, Rats, Sprague-Dawley
Abstract

Mesenchymal stem cells (MSCs) may be of value in regeneration of renal tissue after damage; however, lack of biological knowledge and variability of results in animal models limit their utilization. We studied the effects of MSCs on podocytes in vitro and in vivo utilizing adriamycin (ADR) as a model of renal toxicity. The in vivo experimental approach was carried out in male Sprague-Dawley rats (overall 60 animals) treated with different ADR schemes to induce acute and chronic nephrosis. MSCs were given a) concomitantly to ADR in tail vein or b) in aorta and c) in tail vein 60 days after ADR. Homing was assessed with PKH26-MSCs. MSCs rescued podocytes from apoptosis induced by ADR in vitro. The maximal effect (80% rescue) was obtained with MSCs/podocytes coculture ratio of 1:1 for 72 h. All rats treated with ADR developed nephrosis. MSCs did not modify the clinical parameters (i.e., proteinuria, serum creatinine, lipids) but protected the kidney from severe glomerulosclerosis when given concomitantly to ADR. Rats given MSCs 60 days after ADR developed the same severe renal damage. Only a few MSCs were found in renal tubule-interstitial areas 1-24 h after injection and no MSCs were detected in glomeruli. MSCs reduced apoptosis of podocytes treated with ADR in vitro. Early and repeated MSCs infusion blunted glomerular damage in chronic ADR-induced nephropathy. MSCs did not modify proteinuria and progression to renal failure, which implies lack of regenerative potential in this model.

Published
2008
Full Text
View/download PDF

2. Glomerulocystic kidney disease in a family.

Author

Gusmano R, Caridi G, Marini M, Perfumo F, Ghiggeri GM, Piaggio G, Ceccherini I, and Seri M

Subjects
Child, Child, Preschool, Female, Genes, Dominant, Humans, Kidney diagnostic imaging, Kidney Diseases diagnostic imaging, Kidney Diseases pathology, Male, Pedigree, Ultrasonography, Urography, Cysts genetics, Kidney Diseases genetics, Kidney Glomerulus
Abstract

Background: Glomerulocystic kidney disease (GCKD) is a rare renal disorder, the identity of which has long been discussed. GCKD can occur in a familial form with autosomal dominant transmission. The presence of GCKD in families affected with autosomal dominant polycystic kidney disease (ADPKD) has lent support to the hypothesis that GCKD may be an early manifestation of ADPKD. In families with hypoplastic forms of GCKD, the HNF-1beta gene has recently been identified., Methods: Three members of a family were evaluated: a girl (case 1) and her brother (case 2), who were aged 11 and 12 years, respectively, at the beginning of the study, and, subsequently, the girl's son, when he was 4 years old (case 3). They all had mild renal insufficiency. Clinical, morphological and genetic evaluations were performed on 11 members of the family., Results: Case 1. A mild reduction in renal length with modest dysmorphology of renal calyces and hyperechogenic parenchyma were present when the patient was 11 years old. At the age of 29 some small renal cysts were identified, which remained unchanged over the next 8 years. Renal dysfunction remained stable. Case 2. A slight reduction in size of a hyperechogenic kidney was found. Cysts were seen at the age of 38. Renal dysfunction remained unchanged. Case 3. Kidneys were of normal size. Small cysts were found at the age of 9 years. In cases 1 and 2, histopathology was highly consistent with GCKD. In none of the cases associated pathological conditions could be identified. Haplotype reconstruction allowed the exclusion of PKD1 and PKD2 genes. No mutation of the HNF-1beta gene was found., Conclusions: The morphological data from the three cases are suggestive of GCKD. The involvement of PKD1, PKD2 and HNF-1beta gene mutations was excluded.

Published
2002
Full Text
View/download PDF

4. [Nephronophthisis].

Author

Perfumo F, Formicucci L, Sarperi M, and Gusmano R

Subjects
Acute Kidney Injury etiology, Child, Child, Preschool, Female, Humans, Infant, Kidney Diseases complications, Kidney Diseases pathology, Liver Cirrhosis congenital, Male, Polyuria etiology, Retinal Degeneration genetics, Kidney Diseases genetics
Published
1976

5. [Chronic renal insufficiency in childhood. Importance of congenital nephropathies].

Author

Gusmano R, Perfumo F, Ginevri F, Formicucci L, Berta L, and Richeri E

Subjects
Adolescent, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Kidney Diseases complications, Nephritis, Hereditary complications, Polycystic Kidney Diseases complications, Tuberculosis, Renal complications, Kidney Diseases congenital, Kidney Failure, Chronic etiology
Published
1981

6. [Urate nephropathy in childhood. Lesch-Nyhan disease].

Author

Perfumo F, Basile GC, and Gusmano R

Subjects
Anemia, Megaloblastic etiology, Arthritis etiology, Humans, Hypoxanthine Phosphoribosyltransferase deficiency, Uric Acid blood, Kidney Diseases etiology, Lesch-Nyhan Syndrome complications, Lesch-Nyhan Syndrome metabolism
Published
1976

9. [Evaluation of urinary enzymes in the normal child and those under antibiotic treatment with aminoglycosides].

Author

Basile G, Oleggini R, Perfumo F, and Gusmano R

Subjects
Acetylglucosaminidase urine, Age Factors, Aminoglycosides pharmacology, Child, Child, Preschool, Female, Glucuronidase urine, Humans, Kidney Diseases enzymology, Leucyl Aminopeptidase urine, Male, beta-Galactosidase urine, beta-Glucosidase urine, Aminoglycosides therapeutic use, Enzymes urine, Kidney Diseases drug therapy
Published
1979

12. Risk for chronic kidney disease in the general population italian reports for the the world kiney days 2007-2009

Author

Galassi, A, Brancaccio, D, Andreucci, Ve, Andreucci, M, Caglioti, A, Faga, T, Mazzitello, G, Antonelli, A, Carlini, A, Giusti, R, Rosati, A, Apperti, V, Auricchio, Mr, Avella, F, Barbato, A, Romano, P, Barzaghi, B, Bedani, Pl, Bellinghieri, G, Costantino, G, Bernardi, A, Bolasco, P, Ferrara, R, Pani, A, Bonomini, M, Busnach, G, Conte, F, Limido, A, Messa, Pg, Sinico, Ra, Spotti, D, Cadinu, F, Campieri, C, Capuano, M, Terribile, M, Cardone, F, Paglia, S, Castellino, P, Di Landro, D, Fatuzzo, P, Liuzzo, G, Sicurezza, E, Casu, Md, Centrone, E, Ciofani, A, Cossu, M, D'Amaro, E, D'Apice, L, Dal Canton, A, Fasoli, G, De Ferrari, G, Cappelli, Gianni, Gusmano, R, De Simone, W, Delgado, G, Di Iorio, B, Di Luca, M, Di Natale, E, Farfaglia, P, Cantú, P, Feriozzi, S, Galeotti, P, Fiorini, F, Frascà, Gm, Gallucci, M, Buongiorno, E, Gesualdo, L, Giannattasio, M, Detomaso, F, Giannetto, M, Gianni, S, Giliberti, A, Grassi, C, Lupi, Gp, Imperiali, P, Juliano, P, Li Vecchi, M, Lucenti, T, Maffucci, G, Anelli, Am, Manno, M, Schena, Fp, Mazzaferro, S, Migliorati, M, Morrone, L, Mura, M, Petrarulo, F, Pizzarelli, F, Ricciardi, B, Riccobene, G, Rondanini, V, Russo, D, Sasdelli, M, Mura, C, Scarpino, L, Selvi, S, Tarchini, R, Tedesco, A, Timio, F, Traversari, L, Venditti, G, Viganò, S, Locatelli, F., Galassi, A., Andreucci, M, Caglioti, A., Faga, T., Mazzitello, G., Antonelli, A., Carlini, A., Giusti, R., Rosati, A., Apperti, V., Auricchio, M. R., Avella, F., Barbato, A., Romano, P., Barzaghi, B., Bedani, P. L., Bellinghieri, G., Costantino, G., Bernardi, A., Bolasco, P., Ferrara, R., Pani, A., Bonomini, M., Brancaccio, D., Busnach, G., Conte, F., Limido, A., Messa, P. G., Sinico, R. A., Spotti, D., Cadinu, F., Campieri, C., Capuano, M., Terribile, M., Cardone, F., Paglia, S., Castellino, P., Di Landro, D., Fatuzzo, P., Liuzzo, G., Sicurezza, E., Casu, M. D., Centrone, E., Ciofani, A., Cossu, M., D'Amaro, E., D'Apice, L., Dal Canton, A., Fasoli, G., De Ferrari, G., Cappelli, G., Gusmano, R., De Simone, W., Delgado, G., Di Iorio, B., Di Luca, M., Di Natale, E., Farfaglia, P., Cantù, P., Feriozzi, S., Galeotti, P., Fiorini, F., Frascà, G. M., Gallucci, M., Buongiorno, E., Gesualdo, L., Giannattasio, M., Detomaso, F., Giannetto, M., Gianni, S., Giliberti, A., Grassi, C., Lupi, G. P., Imperiali, P., Juliano, P., Li Vecchi, M., Lucenti, T., Maffucci, G., Anelli, A. M., Manno, M., Schena, F. P., Mazzaferro, S., Migliorati, M., Morrone, L., Mura, M., Petrarulo, F., Pizzarelli, F., Ricciardi, B., Riccobene, G., Rondanini, V., Russo, Domenico, Sasdelli, M., Mura, C., Scarpino, L., Selvi, S., Tarchini, R., Tedesco, A., Timio, M., Traversari, L., Venditti, G., Viganò, S., Locatelli, F., Galassi, A, Caglioti, A, Faga, T, Mazzitello, G, Antonelli, A, Carlini, A, Giusti, R, Rosati, A, Apperti, V, Auricchio, M, Avella, F, Barbato, A, Romano, P, Barzaghi, B, Bedani, P, Bellinghieri, G, Costantino, G, Bernardi, A, Bolasco, P, Ferrara, R, Pani, A, Bonomini, M, Brancaccio, D, Busnach, G, Conte, F, Limido, A, Messa, P, Sinico, R, Spotti, D, Cadinu, F, Campieri, C, Capuano, M, Terribile, M, Cardone, F, Paglia, S, Castellino, P, Di Landro, D, Fatuzzo, P, Liuzzo, G, Sicurezza, E, Casu, M, Centrone, E, Ciofani, A, Cossu, M, D'Amaro, E, D'Apice, L, Dal Canton, A, Fasoli, G, De Ferrari, G, Cappelli, G, Gusmano, R, De Simone, W, Delgado, G, Di Iorio, B, Di Luca, M, Di Natale, E, Farfaglia, P, Cantù, P, Feriozzi, S, Galeotti, P, Fiorini, F, Frascà, G, Gallucci, M, Buongiorno, E, Gesualdo, L, Giannattasio, M, Detomaso, F, Giannetto, M, Gianni, S, Giliberti, A, Grassi, C, Lupi, G, Imperiali, P, Juliano, P, Li Vecchi, M, Lucenti, T, Maffucci, G, Anelli, A, Manno, M, Schena, F, Mazzaferro, S, Migliorati, M, Morrone, L, Mura, M, Petrarulo, F, Pizzarelli, F, Ricciardi, B, Riccobene, G, Rondanini, V, Russo, D, Sasdelli, M, Mura, C, Scarpino, L, Selvi, S, Tarchini, R, Tedesco, A, Timio, M, Traversari, L, Venditti, G, Viganò, S, and Locatelli, F

Subjects
Proteinuria, Time Factors, Italy, Risk Factors, Nephrology, Chronic Disease, Diabetic Nephropathies/etiology, Hypertension, Humans, Diabetic Nephropathies, Kidney Diseases
Published
2010

13. Mesenchymal stem cells protective effect in adriamycin model of nephropathy

Author

Magnasco, A., Corselli, M., Bertelli, R., Ibatici, A., Peresi, M., Gaggero, G., Cappiello, V., Chiavarina, B., Mattioli, Girolamo, Gusmano, R., Ravetti, J. L., Frassoni, F., and Ghiggeri, G. M.

Subjects
Male, Cultured, Animal, Podocytes, Cells, Mesenchymal Stem Cells, Mesenchymal Stem Cell Transplantation, Antineoplastic, Rats, drug effects/physiology, chemically induced/pathology/therapy, Antibiotics, Cell Movement, Cytoprotection, Doxorubicin, Animals, Antibiotics, Antineoplastic, Cell Movement, physiology, Cells, Cultured, Chronic Disease, Cytoprotection, physiology, Disease Models, Animal, Doxorubicin, Humans, Kidney Diseases, chemically induced/pathology/therapy, Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, physiology, Podocytes, drug effects/physiology, Rats, Rats, Sprague-Dawley, physiology, Chronic Disease, Disease Models, Animals, Humans, Kidney Diseases
Published
2008

14. A non-cytotoxic T cell clone from a human kidney graft infiltrate inhibits factor VIII synthesis by donor kidney endothelial cells

Author

Manca, F., Perfumo, F., Valente, Umberto, Barocci, S., and Gusmano, R.

Subjects
Graft Rejection, Cultured, Factor VIII, Helper-Inducer, Cells, T-Lymphocytes, Kidney Transplantation, Cultured, Endothelium, Vascular, metabolism, Factor VIII, biosynthesis, Graft Rejection, Humans, Kidney Diseases, immunology/pathology, Kidney Transplantation, T-Lymphocytes, physiology, T-Lymphocytes, physiology, Humans, immunology/pathology, Kidney Diseases, Endothelium, biosynthesis, metabolism
Published
1988

15. Literature Abstracts.

Author

Candiano, G., Musante, L., Carraro, M., Faccini, L., Campanacci, L., Zennaro, C., Artero, M., Ginevri, F., Perfumo, F., Gusmano, R., Ghiggeri, G.M., Patrakka, J., Kestila, M., Wartiovaara, J., Ruotsalainen, V., Tissari, P., Lenkkeri, U., Mannikko, M., and Visapaa, I.

Subjects
KIDNEY diseases, CHRONIC kidney failure, NEPHROTIC syndrome in children
Abstract

Presents abstracts on two studies involving kidney diseases. Use of apolipoproteins to prevent glomelular albumin permeability alterations induced by serum from patients with chronic renal failure caused by focal segmental glumerulosclerosis; Description of the function of the most commen congenital nephrotic syndrome gene mutations.

Published
2001

Catalog

Books, media, physical & digital resources
See catalog results