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Objectives: To systematically investigate the usability of virtual non-contrast reconstructions (VNC) derived from dual-layer CT (DLCT) for detection and size measurements of kidney stones with regards to different degrees of surrounding iodine-induced attenuation and radiation dose., Methods: Ninety-two kidney stones of varying size (3-14 mm) and composition were placed in a phantom filled with different contrast media/water mixtures exhibiting specific iodine-induced attenuation (0-1500 HU). DLCT-scans were acquired using CTDI vol of 2 mGy and 10 mGy. Conventional images (CI) and VNC 0H-1500HU were reconstructed. Reference stone size was determined using a digital caliper (Man-M). Visibility and stone size were assessed. Statistical analysis was performed using the McNemar test, Wilcoxon test, and the coefficient of determination., Results: All stones were visible on CI 0HU and VNC 200HU . Starting at VNC 400 HU , the detection rate decreased with increasing HU and was significantly lower as compared to CI 0HU on VNC ≥ 600HU (100.0 vs. 94.0%, p < 0.05). The overall detection rate was higher using 10 mGy as compared to 2 mGy protocol (87.9 vs. 81.8%; p < 0.001). Stone size was significantly overestimated on all VNC compared to Man-M (7.0 ± 3.5 vs. 6.6 ± 2.8 mm, p < 0.001). Again, the 10 mGy protocol tended to show a better correlation with Man-M as compared to 2 mGy protocol (R 2 = 0.39-0.68 vs. R 2 = 0.31-0.57)., Conclusions: Detection and size measurements of kidney stones surrounded by contrast media on VNC are feasible. The detection rate of kidney stones decreases with increasing iodine-induced attenuation and with decreasing radiation dose as well as stone size, while remaining comparable to CI 0HU on VNC ≤ 400 HU ., Key Points: • The detection rate of kidney stones on VNC depends on the surrounding iodine-induced attenuation, the used radiation dose, and the stone size. • The detection rate of kidney stones on VNC decreases with greater iodine-induced attenuation and with lower radiation dose, particularly in small stones. • The visibility of kidney stones on VNC ≤ 400 HU remains comparable to true-non-contrast scans even when using a low-dose technique., (© 2022. The Author(s).)

Computed tomography in suspected urolithiasis provides information about the presence, location and size of stones. Particularly stone size is a key parameter in treatment decision; however, data on impact of reformatation and measurement strategies is sparse. This study aimed to investigate the influence of different image reformatations, slice thicknesses and window settings on stone size measurements. Reference stone sizes of 47 kidney stones representative for clinically encountered compositions were measured manually using a digital caliper (Man-M). Afterwards stones were placed in a 3D-printed, semi-anthropomorphic phantom, and scanned using a low dose protocol (CTDI vol 2 mGy). Images were reconstructed using hybrid-iterative and model-based iterative reconstruction algorithms (HIR, MBIR) with different slice thicknesses. Two independent readers measured largest stone diameter on axial (2 mm and 5 mm) and multiplanar reformatations (based upon 0.67 mm reconstructions) using different window settings (soft-tissue and bone). Statistics were conducted using ANOVA ± correction for multiple comparisons. Overall stone size in CT was underestimated compared to Man-M (8.8 ± 2.9 vs. 7.7 ± 2.7 mm, p < 0.05), yet closely correlated (r = 0.70). Reconstruction algorithm and slice thickness did not significantly impact measurements (p > 0.05), while image reformatations and window settings did (p < 0.05). CT measurements using multiplanar reformatation with a bone window setting showed closest agreement with Man-M (8.7 ± 3.1 vs. 8.8 ± 2.9 mm, p < 0.05, r = 0.83). Manual CT-based stone size measurements are most accurate using multiplanar image reformatation with a bone window setting, while measurements on axial planes with different slice thicknesses underestimate true stone size. Therefore, this procedure is recommended when impacting treatment decision., (© 2021. The Author(s).)

Purpose: Computed tomography (CT) is routinely used to assess suspected urolithiasis. Information obtained from CT include presence, location and size of stones, with the latter frequently determining treatment strategy. While there is consensus regarding measurements procedures of kidney stones, influence of radiation dose and reconstruction techniques on stone measurements are unknown. The purpose of this study was to systematically evaluate the influence of these technical determinants on kidney stone size measurements., Method: 47 kidney stones of different composition were scanned using a 64-row-multi-detector CT in a 3D-printed, semi-anthropomorphic phantom. Reference stone sizes were measured manually with a digital caliper (Man-M). Stones were imaged with 2 and 10 mGy CTDI. Images were reconstructed using filtered-back-projection, hybrid-iterative and model-based-iterative reconstruction algorithms (FBP, HIR, MBIR) in combination with different kernels and denoising levels. All stones underwent semi-automatic, threshold-based segmentation for computation of maximum diameter and volume. Statistics were conducted using ANOVA ± correction for multiple comparisons., Results: Overall stone size as compared to manual measurements was overestimated in CT (10.0 ± 3.1 vs. 8.8 ± 2.9 mm, p < 0.05) yet showing a good correlation (R 2  = 0.66). Radiation dose and denoising levels did not significantly influence measurements (p > 0.05). MBIR and sharp kernels showed closest agreement with Man-M (9.3 ± 3.1 vs. 8.8 ± 2.9 mm, p < 0.05). Differences within single stones were as high as 40 % (e.g. Man-M: 5.9 mm, CT: 7.3-12.0 mm)., Conclusions: CT-based measurements of kidney stone size appear unaffected by radiation dose and denoising technique, whereas reconstruction algorithms and kernels demonstrate a relevant impact on size measurements. Smallest differences were found using MBIR with a sharp kernel., (Copyright © 2020 Elsevier B.V. All rights reserved.)