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2 results on '"de Peralta-Venturina M"'

1. Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors.

Author

Skinnider BF, Folpe AL, Hennigar RA, Lim SD, Cohen C, Tamboli P, Young A, de Peralta-Venturina M, and Amin MB

Subjects
Adult, Diagnosis, Differential, Humans, Keratins analysis, Kidney chemistry, Kidney Neoplasms chemistry, Vimentin analysis, Keratins biosynthesis, Kidney metabolism, Kidney Neoplasms metabolism, Vimentin biosynthesis
Abstract

Adult renal epithelial neoplasms (RENs) comprise several distinct clinicopathologic entities with potential prognostic and therapeutic differences. Individual cases can show overlapping morphologic features, necessitating the use of ancillary methods. The purpose of this study was to determine the diagnostic utility of cytokeratin (CK) subtype expression pattern in a wide range of adult RENs. RENs (including clear cell [conventional] renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, renal oncocytoma, collecting duct carcinoma (CDC), renal medullary carcinoma (RMC), urothelial carcinoma, metanephric adenoma (MA), tubulocystic carcinoma (TC) (also known as low-grade collecting duct carcinoma), and mucinous tubular and spindle cell carcinoma) were immunostained for CK subtypes (CK5/CK6, 7, 8, 13, 14, 17, 18, 19, 20), high molecular weight CKs 1, 5, 10, 14 (HMWCK), and vimentin (Vim). The expression pattern of normal kidney was also examined and correlated with RENs. Although there is some overlap, subtypes of RENs show distinctive CK expression profiles that may be useful in several differential diagnostic settings. Clear cell RCCs typically showed a restricted expression pattern of CK8, CK18 and Vim. Papillary RCCs typically expressed CK7, CK8, CK18, CK19, and Vim and could be distinguished from MA (CK7-). Chromophobe RCCs were typically CK7+, CK8+, CK18+, and Vim-, and could be distinguished from oncocytomas (typically CK7-). In oncocytomas, nonspecific staining of unblocked endogenous biotin is a potentially significant diagnostic pitfall. CDC, RMC, and TC demonstrated similar CK expression profiles (with the exception of HMWCK expression limited to CDC), supporting a close relationship between these entities. A panel of CK5/CK6, CK17, and Vim may be helpful in distinguishing CDC (typically CK5/CK6-, CK17-, Vim+) and urothelial carcinoma (typically CK5/CK6+, CK17+, Vim-). In conclusion, CK expression patterns may be helpful in several differential diagnostic situations when dealing with adult RENs.

Published
2005
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2. Reappraisal of Morphological Differences between Renal Medullary Carcinoma, Collecting Duct Carcinoma, and Fumarate Hydratase-Deficient Renal Cell Carcinoma

Author

Gabriella Nesi, Lakshmi P. Kunju, Gladell P. Paner, Fiona Maclean, Scott A. Tomlins, Steven C. Smith, Deepika Sirohi, Mahul B. Amin, Jonathan I. Epstein, Jesse K. McKenney, Anthony J. Gill, Adeboye O. Osunkoya, Pedram Argani, Mitual Amin, Kiril Trpkov, Ying-Bei Chen, Chisato Ohe, Abbas Agaimy, Victor E. Reuter, Michelle S. Hirsch, Eva Comperat, Priya Rao, Maurizio Colecchia, Maria M. Picken, Mariza de Peralta-Venturina, Mukul K. Divatia, Wolfram Jochum, Rohit Mehra, Isabela Werneck da Cunha, Liang Cheng, Ondřej Hes, Cristina Magi-Galluzzi, Luciana Schultz, Satish K. Tickoo, Paulo Guilherme de Oliveira Salles, Ohe, C, Smith, Sc, Sirohi, D, Divatia, M, de Peralta-Venturina, M, Paner, Gp, Agaimy, A, Amin, Mb, Argani, P, Chen, Yb, Cheng, L, Colecchia, M, Comperat, E, da Cunha, Iw, Epstein, Ji, Gill, Aj, Hes, O, Hirsch, M, Jochum, W, Kunju, Lp, Maclean, F, Magi-Galluzzi, C, Mckenney, Jk, Mehra, R, Nesi, G, Osunkoya, Ao, Picken, Mm, Rao, P, Reuter, Ve, Salles, Pgd, Schultz, L, Tickoo, Sk, Tomlins, Sa, and Trpkov, K

Subjects
0301 basic medicine, Male, Pathology, Biopsy, DNA Mutational Analysis, urologic and male genital diseases, Fumarate Hydratase, Collecting duct carcinoma, 0302 clinical medicine, Renal cell carcinoma, SMARCB1, Child, Aged, 80 and over, Kidney, Kidney Medulla, medicine.diagnostic_test, Middle Aged, Immunohistochemistry, Kidney Neoplasms, Europe, medicine.anatomical_structure, Phenotype, 030220 oncology & carcinogenesis, Female, Anatomy, Brazil, Adult, medicine.medical_specialty, Canada, Adolescent, Article, Pathology and Forensic Medicine, Renal medullary carcinoma, Diagnosis, Differential, 03 medical and health sciences, Young Adult, Predictive Value of Tests, medicine, Carcinoma, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Kidney Tubules, Collecting, Carcinoma, Renal Cell, Aged, Retrospective Studies, business.industry, Australia, medicine.disease, United States, 030104 developmental biology, Mutation, Surgery, Hereditary leiomyomatosis and renal cell carcinoma, Neoplasm Grading, business
Abstract

Renal Medullary Carcinomas (RMCs) and Collecting Duct Carcinomas (CDCs) are rare subsets of lethal high-stage, high-grade distal nephron-related adenocarcinomas with a predilection for the renal medullary region. Recent findings have established an emerging group of fumarate hydratase (FH)-deficient tumors related to hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC-RCCs) within this morphologic spectrum. Recently-developed, reliable ancillary testing has enabled consistent separation between these tumor types. Here, we present the clinicopathologic features and differences in the morphological patterns between RMCs, CDCs and FH-deficient RCCs in consequence of these recent developments. This study included a total of 100 cases classified using contemporary criteria and ancillary tests. Thirty-three RMCs (SMARCB1/INI1-deficient, hemoglobinopathy), 38 CDCs (SMARCB1/INI1-retained) and 29 RCCs defined by the FH-deficient phenotype (FH-/2SC+ or FH±/2SC+ with FH mutation, regardless of HLRCC syndromic stigmata/ history) were selected. The spectrum of morphologic patterns was critically evaluated and the differences between the morphological patterns present in the three groups were analyzed statistically. Twenty five percent of cases initially diagnosed as CDC were reclassified as FH-deficient RCC based on our contemporary diagnostic approach. Among the different overlapping morphologic patterns, sieve-like/cribriform and reticular/yolk sac tumor-like patterns favored RMCs, whereas intracystic papillary and tubulocystic patterns favored FH-deficient RCC. Tubulopapillary pattern favored both CDCs and FH-deficient RCCs, and multinodular infiltrating papillary pattern favored CDCs. Infiltrating glandular and solid sheets/cords/nested patterns were not statistically different among the three groups. Viral inclusion-like large nucleoli considered as a hallmark of HLRCC-RCCs were observed significantly more frequently in FH-deficient RCCs. Despite the overlapping morphology found among these clinically aggressive infiltrating high-grade adenocarcinomas of the kidney, reproducible differences in morphology emerged between these categories after rigorous characterization. Finally, we recommend that definitive diagnosis of CDC should only be made if RMC and FH-deficient RCC are excluded.

Published
2018

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