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Your search keyword '"Cramarossa L"' showing total 4 results
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4 results on '"Cramarossa L"'

1. [THE KIDNEY IN INSULIN METABOLISM].

Author

ANDREANI D, NEGRI M, and CRAMAROSSA L

Subjects
Biomedical Research, Insulin, Iodine Isotopes, Kidney, Metabolism, Urine
Published
1964

3. Evidence of drug interaction between cyclosporin A and H2-receptor antagonists (cimetidine, ranitidine and famotidine) in Sprague-Dawley rats

Author

Filingeri, V., Giacomelli, R., Famularo, G., Riccardo ROSATI, Nardi, S., Calogero, A., Iacona, A., Stortoni, F., Cramarossa, L., Sacchetti, S., Cervelli, V., Tonietti, G., and Casciani, C. U.

Subjects
Male, creatinine blood level, animal experiment, Inbred Strains, Cyclosporins, Kidney, Ranitidine, cyclosporin a, histology, rat, Drug Interactions, Aspartate Aminotransferases, kidney function, Non-U.S. Gov't, famotidine, fatty liver, drug interaction, nonhuman, Animal, Alanine Transaminase, cimetidine, liver toxicity, drug metabolism, Rats, Thiazoles, Settore MED/18 - Chirurgia Generale, intraperitoneal drug administration, priority journal, Histamine H2 Antagonists, Liver, cytochrome p450, drug blood level, Creatinine, ranitidine, alanine aminotransferase blood level, aspartate aminotransferase blood level, Cimetidine, Famotidine, Rats, Inbred Strains, Support, Non-U.S. Gov't, Support
Published
1989

4. Evidence of drug interaction between cyclosporin A and H2-receptor antagonists (cimetidine, ranitidine and famotidine) in Sprague-Dawley rats

Author

Filingeri V, Giacomelli R, Famularo G, Riccardo ROSATI, Nardi S, Calogero A, Iacona A, Stortoni F, Cramarossa L, and Sacchetti S

Subjects
Male, Alanine Transaminase, Cyclosporins, Rats, Inbred Strains, Famotidine, Kidney, Ranitidine, Rats, Thiazoles, Histamine H2 Antagonists, Liver, Creatinine, Animals, Drug Interactions, Aspartate Aminotransferases, Cimetidine
Abstract

H2-receptor antagonists, such as cimetidine (C), ranitidine (R) and famotidine (F) seem to be effective in the prevention and treatment of stress ulcer in transplant recipients receiving cyclosporin A (CyA). The aim of this study was to detect the possible synergistic nephro- and hepato-toxicity of these drugs, assaying the serum creatinine (SC), ALT, AST levels, and the histological features of 45 young male Sprague-Dawley rats, divided into nine groups of five rats each. After 10 days of treatment the results showed: (i) serum CyA levels were increased in the group receiving daily CyA (5 mg/kg) + R(5 mg/kg) (2430 +/- 403 ng/ml; p less than 0.05 vs. controls) and in the group receiving daily CyA (5 mg/kg) +/- C (10 mg/kg) (2440 +/- 265 ng/ml; p less than 0.01 vs. controls); (ii) ALT and AST levels were increased in this latter group (ALT 223 +/- 133 UL, AST 114.67 +/- 39 UL; p less than 0.01 vs. controls); (iii) SC levels were normal; and (iv) steatosis of the liver was observed in these two groups. These findings suggest that C and R, but not F, may inhibit the hepatic cytochromes P-450 which are involved in the oxidative metabolism of the drugs. Furthermore, the high serum CyA levels seem to play a major role in the appearance of biochemical and histological damage to the liver.

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