1. Iridium Catalysts with f-Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones.
- Author
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Wu W, Liu S, Duan M, Tan X, Chen C, Xie Y, Lan Y, Dong XQ, and Zhang X
- Subjects
- Alcohols chemistry, Catalysis, Ferrous Compounds chemistry, Hydrogenation, Ligands, Metallocenes chemistry, Models, Molecular, Oxazoles chemistry, Stereoisomerism, Thermodynamics, Alcohols chemical synthesis, Ferrous Compounds chemical synthesis, Iridium chemistry, Ketones chemistry, Metallocenes chemical synthesis, Oxazoles chemical synthesis
- Abstract
A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1 000 000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals.
- Published
- 2016
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