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Your search keyword '"Aalia Rasool Sufi"' showing total 4 results
Start Over Author "Aalia Rasool Sufi" Topic keratoconus
4 results on '"Aalia Rasool Sufi"'

1. Structural Changes in Thin Keratoconic Corneas Following Crosslinking with Hypotonic Riboflavin: Findings on In Vivo Confocal Microscopy

Author

Aalia Rasool Sufi, M. Soundaram, Nilam Gohil, Jeremy D. Keenan, and N. Venkatesh Prajna

Subjects
collagen crosslinking, hypotonic riboflavin, in vivo confocal microscopy, keratoconus, Ophthalmology, RE1-994
Abstract

Abstract Purpose: To report structural changes observable in in vivo confocal microscopy (IVCM) in keratoconic corneas < 400 μm treated with hypotonic riboflavin and collagen crosslinking (CXL). Methods: Ten eyes of ten patients with progressive keratoconus and corneal thickness between 350 and 399 μm underwent CXL with hypotonic riboflavin. IVCM was performed preoperatively and at one month, three months, and six months after the procedure. Results: IVCM analysis one month postoperatively showed complete absence of the subepithelial nerve plexus with gradual regeneration over six months in 8 of the 10 eyes, and poor regeneration in the remaining 2 eyes. The anterior stroma showed extracellular lacunae and hyper-reflective cytoplasm in a honeycomb appearance signifying edema at one month which gradually decreased over six months post CXL. Stromal keratocyte apoptosis was evident in the anterior stroma in all cases and extended to the posterior stroma in four eyes with gradual regeneration evident at three and six months. The specular endothelial count decreased by 8% (P = 0.005) post-CXL, but no corneas developed clinical signs of endothelial trauma. Conclusion: IVCM analysis of thin corneas after hypotonic CXL showed posterior corneal structural changes. Posterior stromal changes were accompanied by a decrease in the endothelial cell count. This case series was a preliminary feasibility study that might necessitate conducting a well-designed controlled study.

Published
2021
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2. Structural Changes in Thin Keratoconic Corneas Following Crosslinking with Hypotonic Riboflavin: Findings on In Vivo Confocal Microscopy

Author

Jeremy D. Keenan, Aalia Rasool Sufi, M Soundaram, N. Venkatesh Prajna, and Nilam Gohil

Subjects
Keratoconus, medicine.medical_specialty, collagen crosslinking, Stromal cell, business.industry, keratoconus, Regeneration (biology), Nerve plexus, Riboflavin, RE1-994, medicine.disease, eye diseases, Ophthalmology, medicine.anatomical_structure, Stroma, Edema, hypotonic riboflavin, medicine, Tonicity, sense organs, medicine.symptom, business, in vivo confocal microscopy
Abstract

Purpose: To report structural changes observable in in vivo confocal microscopy (IVCM) in keratoconic corneas

Published
2021
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4. Comparison of In Vivo Confocal Microscopy, Ultrasonic Pachymetry, and Scheimpflug Topography for Measuring Central Corneal Thickness

Author

N. Venkatesh Prajna, Soundaram MeenakshiSundaram, Jeremy D. Keenan, and Aalia Rasool Sufi

Subjects
Male, Keratoconus, medicine.medical_specialty, Corneal Pachymetry, Scheimpflug principle, law.invention, Cornea, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Optics, Confocal microscopy, law, Ophthalmology, parasitic diseases, Microscopy, medicine, Photography, Humans, Prospective Studies, Corneal pachymetry, Microscopy, Confocal, medicine.diagnostic_test, business.industry, Corneal Topography, Reproducibility of Results, Organ Size, medicine.disease, Corneal topography, eye diseases, medicine.anatomical_structure, Cross-Sectional Studies, Acanthamoeba keratitis, 030221 ophthalmology & optometry, Female, sense organs, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Importance In vivo confocal microscopy could be useful in cases of fungal or acanthamoeba keratitis to determine the depth of infectious elements, but its accuracy in determining corneal thickness relative to more traditional techniques has not been well characterized. Observations In this cross-sectional observational case series, central corneal thickness was determined by in vivo confocal microscopy, ultrasonic pachymetry, and Scheimpflug topography in 47 normal corneas and 23 keratoconic corneas from November 2014 to July 2015. Analyses undertaken from July 2015 to August 2015 showed that confocal microscopy overestimated the central corneal thickness in nonkeratoconic eyes, measuring on average 5 μm thicker (95% limits of agreement [LoA], 54-64) than ultrasonic pachymetry and 14 μm thicker (95% LoA, 47-76) than Scheimpflug topography. The bias was more pronounced in keratoconic eyes, where confocal microscopy overestimated central corneal thickness by 50 μm relative to ultrasonic pachymetry (95% LoA, 77-178) and 52 μm relative to Scheimpflug topography (95% LoA, 69-174). Conclusions and Relevance Confocal microscopy overestimated central corneal thickness relative to the other instruments, but the magnitude of the differences were small, especially in nonkeratoconic eyes. This level of measurement bias is acceptable to us for determining the depth of fungal filaments and acanthamoeba cysts in infectious keratitis.

Published
2016

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