1. Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation
- Author
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Yasunari Takakuwa, Yukari Fukushima, Koji Kuronuma, Shin-ichi Yokota, Kaoru Nishiyama, Takayuki Wada, Tsukasa Shiraishi, Hiroyuki Honda, Hiroki Takahashi, Hiromi Murabayashi, Yasuhiko Suzuki, Chie Nakajima, Yasuo Ohkoshi, and Toyotaka Sato
- Subjects
0301 basic medicine ,Microbiology (medical) ,medicine.drug_class ,030106 microbiology ,Drug resistance ,Microbial Sensitivity Tests ,Biology ,medicine.disease_cause ,Serogroup ,Pneumococcal Infections ,Microbiology ,Macrolide Antibiotics ,03 medical and health sciences ,chemistry.chemical_compound ,Japan ,Streptococcus mitis ,Drug Resistance, Multiple, Bacterial ,Streptococcus pneumoniae ,medicine ,Humans ,Pharmacology (medical) ,Whole Genome Sequencing ,biochemical phenomena, metabolism, and nutrition ,Disseminated Intravascular Coagulation ,Middle Aged ,bacterial infections and mycoses ,biology.organism_classification ,Anti-Bacterial Agents ,Multiple drug resistance ,Infectious Diseases ,chemistry ,Linezolid ,Vancomycin ,Female ,Daptomycin ,Tomography, X-Ray Computed ,Genome, Bacterial ,medicine.drug - Abstract
Multidrug-resistant Streptococcus pneumoniae strains were isolated from blood and sputum of a patient with disseminated intravascular coagulation in Sapporo city, Japan. These antibiograms were only susceptible to vancomycin, linezolid, daptomycin, some carbapenems, and some fluoroquinolones. Identical antibiograms, serotypes (19F), and sequence types (ST10017) suggested a shared origin of these isolates. Only one ST10017 strain has been isolated in the same city in Japan previously (2014), and the 2014 isolate is still susceptible to macrolides. The whole genome of the blood-derived isolate was sequenced. The strain harbored resistance mutations in parC, gyrA, pbp1a, pbp2a, pbp2b, and pbp2x, and harbored the resistance genes, ermB and tetM. The nucleotide sequences of parC and pbp2x genes of strain MDRSPN001 were clearly different from those of other S. pneumoniae strains and were similar to those of oral streptococci strains. These findings suggest that strain MDRSPN001 has been rapidly and drastically evolving multidrug resistance by gene replacement and accumulation of genes originating from other strains, such as oral streptococci, Streptococcus mitis.
- Published
- 2017