1. Arterial Reconstruction for Patients with Chronic Limb Ischemia Improves Ambulatory Function and Health-related Quality of Life.
- Author
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Sasajima T, Sasajima Y, Akazawa K, and Saito Y
- Subjects
- Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Intermittent Claudication diagnosis, Intermittent Claudication physiopathology, Ischemia diagnosis, Ischemia physiopathology, Japan, Longitudinal Studies, Male, Middle Aged, Peripheral Arterial Disease diagnosis, Peripheral Arterial Disease physiopathology, Prospective Studies, Recovery of Function, Severity of Illness Index, Time Factors, Treatment Outcome, Vascular Patency, Endovascular Procedures adverse effects, Exercise Tolerance, Intermittent Claudication surgery, Ischemia surgery, Peripheral Arterial Disease surgery, Quality of Life, Vascular Grafting adverse effects, Walking
- Abstract
Background: Arterial reconstruction (AR) for limb ischemia may improve ambulatory function (AF) and health-related quality of life (HR-QoL). However, the efficacy of AR in terms of HR-QoL varies in studies, probably because of cohort differences in disease severity, hemodynamic outcomes, and observation duration. We assessed HR-QoL for patients with various severities of ischemia in a 3-year observational study., Methods: We conducted a single-center 3-year observational study using Short Form 36 in patients with chronic limb ischemia. Between 2001 and 2009, 515 consecutive patients had AR, and 330 who underwent elective AR consented to the study. Of the 330 patients (claudicants 49%, critical limb ischemia [CLI] 51%), 307 underwent bypass and 23 endovascular therapy. Postal questionnaires were sent after AR, and 8 domains, the physical and mental component summary (PCS and MCS) scores, and the patient-reported AF were compared, and negative predictors were identified., Results: Overall, the MCS was minimally affected, but AF and the PCS were impaired. After AR, these measures were significantly improved, and maximum recovery was attained at 6 months. In subgroup analysis, significant predictors of a negative impact on postoperative PCS included age ≥80, CLI, physical aftereffects of stroke (PAS), and previous major amputation (PMA). Of these, PMA was associated with the lowest PCS score, followed by PAS; for these patients, AR contributed minimally to HR-QoL recovery. PCS scores of claudicants attained a maximum value at 6 months; however, PCS scores of CLI patients were significantly lower than intermittent claudication patients (P < 0.0001), and patients with major tissue loss required 2 years to attain maximum PCS recovery., Conclusions: This 3-year observational study verified the efficacy of AR in improving AF and HR-QoL. Age ≥80, CLI, PAS, and PMA were definitive predictors, and for patients with the latter 2, AR contributed minimally to improving HR-QoL., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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