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Start Over Author "Xuicai Fang" Topic irritable bowel syndrome
3 results on '"Xuicai Fang"'

1. A comparative study of disorders of gut–brain interaction in Western Europe and Asia based on the Rome foundation global epidemiology study

Author

Johann P. Hreinsson, Reuben K. M. Wong, Jan Tack, Peter Whorwell, Marc A. Benninga, Viola Andresen, Bruno Bonaz, Suck Chei Choi, Enrico S. Corazziari, Javier Santos, Shin Fukudo, Motoyori Kanazawa, Xuicai Fang, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Magnus Simrén, Institut Català de la Salut, [Hreinsson JP] Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [Wong RKM] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [Tack J] Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium. [Whorwell P] University of Manchester, Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, UK. [Benninga MA] Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition, Amsterdam, The Netherlands. [Andresen V] Department of Medicine, Israelitic Hospital, Hamburg, Germany. [Santos J] Laboratori de Fisiologia i Fisiopatologia Digestiva, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Aparell Digestiu, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHED), Instituto de Salud Carlos III, Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus, Pediatrics, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and ARD - Amsterdam Reproduction and Development

Subjects
Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], IRRITABLE-BOWEL-SYNDROME, Physiology, Clinical Neurology, QUESTIONNAIRE, cross-sectional studies, Qüestionaris, Nervous System::Central Nervous System::Brain [ANATOMY], Aparell digestiu - Malalties - Epidemiologia, sistema nervioso::sistema nervioso central::encéfalo::prosencéfalo::telencéfalo::cerebro [ANATOMÍA], CRITERIA, functional gastrointestinal disorders, Cervell, SCALE, irritable bowel syndrome, Science & Technology, Gastroenterology & Hepatology, Còlon irritable - Epidemiologia, Endocrine and Autonomic Systems, enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritable [ENFERMEDADES], Neurosciences, Gastroenterology, técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], functional constipation, functional dyspepsia, PREVALENCE, SEVERITY, Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases, Functional::Irritable Bowel Syndrome [DISEASES], RISK-FACTORS, Neurosciences & Neurology, Life Sciences & Biomedicine
Abstract

Functional constipation; Functional dyspepsia; Functional gastrointestinal disorders Estreñimiento funcional; Dispepsia funcional; Trastornos gastrointestinales funcionales Restrenyiment funcional; Dispèpsia funcional; Trastorns gastrointestinals funcionals Objective Many studies have been published on disorders of the gut–brain interaction (DGBI) in Asia and Western Europe, but no previous study has directly assessed the difference between the two regions. The aim was to compare the prevalence of DGBI in Asia and Western Europe. Methods We used data collected in a population-based Internet survey, the Rome Foundation Global Epidemiology Study, from countries in Western Europe (Belgium, France, Germany, Netherlands, Italy, Spain, Sweden, and the United Kingdom) and Asia (China, Japan, South Korea, and Singapore). We assessed DGBI diagnoses (Rome IV Adult Diagnostic Questionnaire), anxiety/depression (Patient Health Questionnaire-4, PHQ-4), non-GI somatic symptoms (PHQ-12), and access to and personal costs of doctor visits. Results The study included 9487 subjects in Asia and 16,314 in Western Europe. Overall, 38.0% had at least one DGBI; younger age, female sex, and higher scores on PHQ4 and PHQ12 were all associated with DGBI. The prevalence of having at least one DGBI was higher in Western Europe than in Asia (39.1% vs 36.1%, OR 1.14 [95% CI 1.08–1.20]). This difference was also observed for DGBI by anatomical regions, most prominently esophageal DGBI (OR 1.67 [1.48–1.88]). After adjustment, the difference in DGBI prevalence diminished and psychological (PHQ-4) and non-GI somatic symptoms (PHQ-12) had the greatest effect on the odds ratio estimates. Conclusion The prevalence of DGBI is generally higher in Western Europe compared to Asia. A considerable portion of the observed difference in prevalence rates seems to be explained by more severe psychological and non-GI somatic symptoms in Western Europe.

Published
2023

2. Greater Overlap of Rome IV Disorders of Gut-Brain Interactions Leads to Increased Disease Severity and Poorer Quality of Life

Author

Imran Aziz, Eamonn Martin Quigley, Douglas A. Drossman, William E. Whitehead, Ami D. Sperber, Edith N. Okeke, Tamar Freud, Max Schmulson, John Kellow, Rutaba Khatun, Peter J. Whorwell, Shrikant I. Bangdiwala, Dan L. Dumitrascu, Magnus Simren, Olafur S. Palsson, Shin Fukudo, Xuicai Fang, Uday C Ghoshal, and Jan Tack

Subjects
Adult, Male, psychosocial, medicine.medical_specialty, Gastrointestinal Diseases, Rome, Severity of Illness Index, Irritable Bowel Syndrome, 03 medical and health sciences, 0302 clinical medicine, Functional gastrointestinal disorder, Quality of life, Surveys and Questionnaires, Internal medicine, Epidemiology, medicine, Humans, overlap, Depression (differential diagnoses), Irritable bowel syndrome, functional disorders, DGBI, Hepatology, business.industry, Gastroenterology, Brain, medicine.disease, Comorbidity, 030220 oncology & carcinogenesis, Quality of Life, Functional constipation, Female, epidemiology, 030211 gastroenterology & hepatology, business, Somatization
Abstract

BACKGROUND AND AIMS: Conditions such as irritable bowel syndrome (IBS), functional dyspepsia, and functional constipation are among the prevalent gastrointestinal (GI) disorders classified as disorders of gut-brain interaction (DGBI), which can adversely affect the lives of sufferers. This study aimed to assess the degree and consequences of overlapping DGBI in a large population-based global scale. METHODS: Internet survey data from 54,127 adults (49.1% women) in 26 countries were analyzed by 4 GI anatomic regions (esophageal, gastroduodenal, bowel, and anorectal). The number of DGBI-affected GI regions was assessed, including associations with sex, age, disease severity, quality of life, psychosocial variables, and health care utilization. RESULTS: A total of 40.3% of surveyed individuals met Rome IV criteria for a DGBI. The percentages with 1-4 DGBI-affected GI regions were 68.3%, 22.3%, 7.1%, and 2.3%, respectively. The IBS symptom severity score increased significantly from 1 (207.6) to 4 (291.6) regions, as did non-GI symptom reporting (somatization), anxiety and depression, concerns and embarrassment about bowel function, doctor visits, medications, and abdominal surgeries (all P < .0001). Quality of life decreased with increasing number of DGBI regions (P < .0001). In a logistic mixed model, non-GI symptoms (odds ratio [OR], 1.09; 95% confidence interval [CI], 1.08-1.10), being very vs not concerned (OR, 2.55; 95% CI, 2.27-2.90), being very vs not embarrassed about bowel function (OR, 1.20; 95% CI, 1.08-1.33), and mean number of doctor visits (OR, 1.23; 95% CI, 1.115-1.32) were most strongly associated with number of DGBI regions. CONCLUSIONS: DGBI in multiple anatomic GI regions is associated with increased psychological comorbidity, health care utilization, and IBS severity. Physician awareness of overlap could improve quality of care, prevent unnecessary interventions, and yield more positive health outcomes. ispartof: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY vol:20 issue:5 pages:E945-E956 ispartof: location:United States status: published

Published
2022

3. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Author

Stephen J. Vanner, Iradj Maleki, Ammar Hassanzadeh Keshteli, Payman Adibi, Olafur S. Palsson, Dan L. Dumitrascu, Sandie R Thomson, Douglas A. Drossman, William E. Whitehead, Aurelio López-Colombo, Mashiko Setshedi, Max Schmulson, Yeong Yeh Lee, Bruno Bonaz, Oksana Stefanyuk, Jan Tack, Eamonn Martin Quigley, Enrico Corazziari, Valeria Costa, Edith N. Okeke, Magnus Simren, Timothy N. Archampong, John Kellow, Luis M. Bustos Fernandez, Uday C Ghoshal, Shrikant I. Bangdiwala, Nitesh Pratap, Viola Andresen, Motoyori Kanazawa, Suck Chei Choi, Rutaba Khatun, Leonid Lazebnik, Serhat Bor, Ram Dickman, M Masudur Rahman, Xuicai Fang, Pierre Poitras, Reuben K. Wong, Ami D. Sperber, Carlos Fernando de Magalhães Francisconi, Shin Fukudo, Peter J. Whorwell, Marc A. Benninga, Agata Mulak, Albis Hani, Javier Santos, Ari Fahrial Syam, Judith Zeevenhooven, Institut Català de la Salut, [Sperber AD] Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. [Bangdiwala SI] Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [Drossman DA] Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, North Carolina. [Ghoshal UC] Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India. [Simren M] Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [Tack J] Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium. [Santos J] Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Laboratori de Neuro-Inmuno-Gastroenterologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, and Ege Üniversitesi

Subjects
Adult, Male, atención a la salud (salud pública)::salud de grupos específicos::salud global [SALUD PÚBLICA], 0301 basic medicine, Patient-Reported Outcomes Measurement Information System, medicine.medical_specialty, Adolescent, Gastrointestinal Diseases, Other subheadings::Other subheadings::/epidemiology [Other subheadings], Global Health, Enquestes, Características de la Población::demografía::estadísticas vitales::morbilidad::prevalencia [ATENCIÓN DE SALUD], Population Characteristics::Demography::Vital Statistics::Morbidity::Prevalence [HEALTH CARE], Young Adult, enfermedades del sistema digestivo::enfermedades gastrointestinales [ENFERMEDADES], 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Functional gastrointestinal disorder, Quality of life, Surveys and Questionnaires, IBS, Health care, Epidemiology, Prevalence, Humans, Medicine, Sex Distribution, Health Care (Public Health)::Health of Specific Groups::Global Health [PUBLIC HEALTH], Irritable bowel syndrome, Aged, Salut mundial, DGBI, Hepatology, business.industry, Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], Gastroenterology, Odds ratio, Middle Aged, medicine.disease, Confidence interval, 030104 developmental biology, Female, 030211 gastroenterology & hepatology, epidemiology, Tracte gastrointestinal - Malalties - Epidemiologia, Digestive System Diseases::Gastrointestinal Diseases [DISEASES], business, Demography
Abstract

BACKGROUND & AIMS: Although functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents. METHODS: Data were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately. RESULTS: Among the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9-40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2-21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6-1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3-1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%). CONCLUSIONS: in a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews., Ironwood; Shire; AllerganAllergan; TakedaTakeda Pharmaceutical Company Ltd; Fundamental Research Grant Scheme (FRGS) of the Ministry of Education of Malaysia [203.PPSP.6171192]; Takeda-Israel; Romanian Society of Neurogastroenterology, The study was funded, in part, by research grants from Ironwood, Shire, Allergan, and Takeda. The study in Malaysia was funded by the Fundamental Research Grant Scheme (FRGS) of the Ministry of Education of Malaysia (Reference: 203.PPSP.6171192). The study in Israel was funded by Takeda-Israel. The study in Romania was funded by the Romanian Society of Neurogastroenterology. None of the funders was involved in the planning, design, implementation, statistical analyses or any other aspect of the study including preparation of the paper or knowledge of its contents.

Published
2021

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