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Ion channels can tailor their activity to the particular cellular context by incorporating auxiliary subunits that are channel-type specific. In this issue of Cell, Ávalos Prado et al. now find that a well-characterized voltage-gated K + channel auxiliary subunit can also modulate the gating of Ca 2+ -activated Cl - channels., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Voltage sensing by ion channels is the key event enabling the generation and propagation of electrical activity in excitable cells. In this issue of Cell, Wisedchaisri et al. provide a structural view of a voltage-gated sodium channel in its resting closed conformation., (Copyright © 2019 Elsevier Inc. All rights reserved.)