1. Optimization of coronary optical coherence tomography imaging using the attenuation-compensated technique: a validation study
- Author
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Teo, Jing Chun, Foin, Nicolas, Otsuka, Fumiyuki, Bulluck, Heerajnarain, Fam, Jiang Ming, Wong, Philip, Low, Fatt Hoe, Leo, Hwa Liang, Mari, Jean-Martial, Joner, Michael, Girard, Michael J A, Virmani, Renu, Bezerra, HG., Costa, MA., Guagliumi, G., Rollins, AM., Simon, D., Gutiérrez-Chico, JL., Alegría-Barrero, E., Teijeiro-Mestre, R., Chan, PH., Tsujioka, H., de Silva, R., Otsuka, F., Joner, M., Prati, F., Virmani, R., Narula, J., Members, WC., Levine, GN., Bates, ER., Blankenship, JC., Bailey, SR., Bittl, JA., Mintz, G.S., Costa, Marco, Regar, E., Akasaka, T., Roleder, T., Jąkała, J., Kałuża, GL., Partyka, Ł., Proniewska, K., Pociask, E., Girard, MJA., Strouthidis, NG., Ethier, CR., Mari, JM., Park, SC., van der Lee, R., Foin, N., Wong, P.K., Mari, J-M., Nakano, M., Vorpahl, M., Taniwaki, M., Yazdani, SK., Finn, AV., Yahagi, K., Yamamoto, H., Ladich, ER., Girard, MJ., Ang, M., Chung, CW., Farook, M., Strouthidis, N., Mehta, JS., Nijjer, S., Sen, S., Petraco, R., Ghione, M., Liu, X., Kang, JU., Kolodgie, F.D., Burke, AP., Farb, A., Schwartz, S.M., Davis, HR., Kume, T., Kawamoto, T., Watanabe, N., Toyota, E., Neishi, Y., Rieber, J., Meissner, O., Babaryka, G., Reim, S., Oswald, M.E., Koenig, A.S., Tearney, G. J., Adriaenssens, T., Barlis, P., Yabushita, H., Bouma, BE., Houser, S. L., Aretz, HT., Jang, I-K., Schlendorf, KH., Guo, J., Sun, L., Chen, Y.D., Tian, F., Liu, HB., Chen, L., Kawasaki, M., Bressner, J. E., Nadkarni, S. K., MacNeill, BD., Jansen, CHP., Onthank, DC., Cuello, F., Botnar, RM., Wiethoff, AJ., Warley, A., von Birgelen, C., Hartmann, A. M., Kubo, T., Shite, J., Suzuki, T., Uemura, S., Yu, B., Habara, M., Nasu, K., Terashima, M., Kaneda, H., Yokota, D., Ko, E., Takarada, S., Imanishi, T., Tanimoto, T., Kitabata, H., Nakamura, N., Hattori, K., Ozaki, Y., Ismail, TF., Okumura, M., Naruse, H., Kan, S., Nishio, R., Shinke, T., Otake, H., Nakagawa, M., Nagoshi, R., Inoue, T., Sinclair, H.D., Bourantas, C., Bagnall, A., Kunadian, V., van Soest, G., Goderie, T., Koljenović, S., Leenders, GL. van, Gonzalo, N., Xu, C., Schmitt, JM., Carlier, SG., van der Meer, FJ, Faber, D.J., Sassoon, DMB., Aalders, M.C., Pasterkamp, G., Leeuwen, TG. van, Knuttel, A., Yadlowsky, M., Eckhaus, MA., Karamata, B., Laubscher, M., Leutenegger, M., Bourquin, S., Lasser, T., Lambelet, P., Vermeer, K.A., Mo, J., Weda, J.J.A., Lemij, H.G., Boer, JF. de, Biophotonics and Medical Imaging, LaserLaB - Biophotonics and Microscopy, Application des ultrasons à la thérapie (LabTAU), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM), Géopôle du Pacifique Sud (GePaSUD), Université de la Polynésie Française (UPF), Department of Urology Université de Montréal, and National University of Singapore (NUS)
- Subjects
Male ,STATIN THERAPY ,genetic structures ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Severity of Illness Index ,01 natural sciences ,Cohort Studies ,0302 clinical medicine ,Cause of Death ,Intravascular ultrasound ,Image Processing, Computer-Assisted ,Contrast (vision) ,Prospective Studies ,media_common ,medicine.diagnostic_test ,General Medicine ,Middle Aged ,INTEGRATED BACKSCATTER-IVUS ,Female ,Tomography ,Radiology ,Cardiology and Cardiovascular Medicine ,Tomography, Optical Coherence ,medicine.medical_specialty ,IMAGES ,media_common.quotation_subject ,Image processing ,Risk Assessment ,Sensitivity and Specificity ,CLASSIFICATION ,010309 optics ,03 medical and health sciences ,ENHANCEMENT ,VULNERABLE PLAQUE ,Optical coherence tomography ,SDG 3 - Good Health and Well-being ,0103 physical sciences ,INTRAVASCULAR ULTRASOUND ,medicine ,Humans ,DIAGNOSTIC-ACCURACY ,Radiology, Nuclear Medicine and imaging ,ADAPTIVE COMPENSATION ,Ultrasonography, Interventional ,Aged ,business.industry ,Attenuation ,Survival Analysis ,Vulnerable plaque ,OCT ,Nuclear medicine ,business ,Kappa - Abstract
International audience; Aim To optimize conventional coronary optical coherence tomography (OCT) images using the attenuation-compensated technique to improve identification of plaques and the external elastic lamina (EEL) contourMethods and results The attenuation-compensated technique was optimized via manipulating contrast exponent C, and compression exponent N, to achieve an optimal contrast and signal-to-noise ratio (SNR). This was applied to 60 human coronary lesions (38 native and 22 stented) ex vivo conventional coronary OCT images acquired from heart autopsies of 10 patients and matching histology was available as reference. Three independent reviewers assessed the conventional and attenuation-compensated OCT images blindly for plaque characteristics and EEL detection. Conventional OCT and compensated OCT assessment were compared against histology. Using an optimized algorithm, the attenuation-compensated OCT images had a 2-fold improvement in contrast between different tissues in both stented and non-stented epicardial coronaries (P < 0.05). Overall sensitivity and specificity for plaque classification increased from 84 to 89% and from 92 to 94%, respectively, with substantial agreement among the three reviewers (Fleiss' Kappa k, 0.72 and 0.71, respectively). Furthermore, operators were 2.5 times more likely to identify the EEL contour in the attenuation-compensated OCT images (k = 0.72) than in the conventional OCT images (k = 0.36)Conclusion The attenuation-compensated technique can be retrospectively applied to conventional OCT images and improves the detection of plaque characteristics and the EEL contour. This approach could complement conventional OCT imaging in the evaluation of plaque characteristics and quantify plaque burden in the clinical setting.
- Published
- 2016
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