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Purpose: To investigate anterior segment parameters (ASPs) and dry eye disease (DED), including the status of the meibomian glands, in patients with acromegaly., Methods: In this cross-sectional, comparative study, 36 acromegaly patients and 40 healthy sex- and age-matched controls were included. Participants received a comprehensive ophthalmological examination, including intraocular pressure measurements with Goldmann applanation tonometry (IOP GAT ) and central corneal thickness corrected intraocular pressure (IOP CCT ) measurements, and were evaluated for ASPs and DED. For ASPs, white-to-white (WTW), apical (ACT) and thinnest corneal thickness (TCT), corneal volume (CV), keratometry readings (K 1 , K 2 , and K mean ), anterior chamber depth (ACD) and volume (ACV), and iridocorneal angle (ICA) were obtained via Sirius topography. DED was assessed with Schirmer's test, tear breakup time (TBUT), and Ocular Surface Disease Index (OSDI) scores. Meibography scores (MSs) were obtained with the Sirius topography device., Results: Patients had higher mean IOP GAT (P = .006), IOP CCT (P = .01), ACT (P = .024), and TCT (P = .005) but narrower ICA (P = .014) than controls. Although Schirmer's test did not differ between the groups (P = .442), patients had higher OSDI (P < .001), higher MS (P = .001), and shorter TBUT (P = .002)., Conclusion: Patients with acromegaly have greater IOP, greater corneal thickness, but narrower ICA than healthy individuals, as well as DED with increased MSs, which suggests meibomian gland dysfunction., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Purpose: We aimed to investigate retinal thickness data in these patients with non-refractory pseudophakic cystoid macular edema. Materials and Methods: We retrospectively reviewed patients with non-persistent pseudophakic cystoid macular edema who responded to topical therapy plus follow-up within 3 months between January 2018 and October 2020. Age, gender, anterior and posterior segment findings, intraocular pressures, refractive errors and axial lengths of the patients were recorded. Macular layers, volumes and ganglion cell analysis were examined by optical coherence tomography. The distance between the inner limiting membrane and the outer limiting membrane was measured in the inner retinal layer, and it was recorded as M1. Results: The mean age was 71.33±7.12 in the patients included. Baseline visual acuity was 0.48±0.23 in logMAR in the patient group, while final visual acuity was 0.1±0.096 in logMAR. Average recovery time was 2 months (1-3 months). When the patient and healthy eyes were compared, significant thinning was found in 9 quadrants according to the ETDRS, inner retinal layer (M1), foveal thickness. A strong positive correlation was found between post-treatment vision levels and M1 measurements of eyes with PCME. (p= 0.000) Conclusion: It should be kept in mind that even if vision is restored in non-resistant cystoid macular edema, it may cause atrophy in the retinal layers. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to evaluate the relationship between optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) parameters in a healthy population and to detect any changes that occur with age. Methods: A total of 100 healthy participants were included in this prospective, observational, and comparative study. The participants were categorized in 4 groups according to age: Group 1: 21-30 years, Group 2: 31-40 years, Group 3: 41-50 years, Group 4: 51-60 years of age. Mean macular thickness, retinal nerve fiber layer (RNFL), ganglion cell inner plexiform layer (GC-IPL), and the choroidal thickness (ChT), vessel density (VD), perfusion density (PD), foveal avascular zone (FAZ), and parapapillary perfusion density parameters were recorded and analyzed. Results: In comparisons between groups, no significant difference in OCTA parameters was observed. There were inverse correlations between the outer VD, PD, and intraocular pressure (IOP) (r= -0.307, p=0.006 and r= -0.284, p=0.011, respectively). The correlation between parapapillary perfusion density and IOP was close to being significant (r= -0.213, p=0.059). There were significant relationships between OCTA parameters and macular, RNFL, and GC-IPL thickness. No significant relationship between ChT and OCTA parameters was seen. Conclusion: The size and characteristics of superficial VD, PD, parapapillary perfusion density, and FAZ were determined in a population with standardized demographic and ocular clinical features, and the relationship between these parameters and retinal layers was established. [ABSTRACT FROM AUTHOR]