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Of the 40 patients, stenoses of major brain arteries were identified in 34, occlusions in 6, affection of two arteries in eleven patients, that of three arteries in 3 patients. The following disturbances in central hemodynamics were detected: arterial pressure getting higher, this referring also to the peripheral vascular resistance, hematocrit value, with the bloodflow in the arm-ear portion slowing down, hemodynamics being predominantly of hyperkinetic type. Treatment with cavinton, cavinton plus corglucone resulted in improvement of bloodflow in the affected major brain arteries at the expense of a compensating redistribution of bloodflow from intact collectors to the stenosed arteries basin. Changes in central hemodynamics were manifested by increase in the number of cases presenting with eukinetic-type circulation at the expense of decrease in those of hyperkinetic type. Under hypokinetic type hemodynamics, it is advisable that cavinton be prescribed in combination with cardiac glycosides.

As many as 34 patients having stage II-III atherosclerotic dyscirculatory encephalopathy with coexisting ischemic heart disease in the presence of stenosing and occlusive lesions of major brain arteries were evaluated for effects pentoxiphyllin and corglycon on the clinical course of this medical condition as well as systemic and cerebral haemodynamics. In this series, 82.7 percent of patients derived benefit from a single intravenous infusion of pentoxiphyllin and corglycon and course treatment with these drug preparation that was evidenced by an improvement in the parameters of systemic and cerebral hemodynamics and regression of neurologic symptomatology. The results of the studies made permit recommending pentoxiphyllin in combination with corglycon for treatment of those DE patients with eukinetic and hypokinetic types systemic haemodynamics, whereas pentoxiphyllin alone--for those with hyperkinetic type of haemodynamics, taking into consideration its cardiodepressive effects.

Overall thirty-five patients with ischemic insult against the background of occlusive lesions of major arteries of the head were evaluated for effects of cardil on systemic and cerebral hemodynamics and rheologic properties of blood. It has been shown that cardil increases significantly cerebral bloodflow predominantly on the side of the stenosis, does not cause intracerebral "stealing" in the acute phase of insult, improves bloodflow to the brain and collateral blood supply in the residual phase due to selectivity of its influence on cerebral vessels, lowers arterial pressure, decreases frequency of contractions, as well as cardial and stroke indices, and volume of circulating blood. The drug suppresses aggregatory properties of thrombocytes and erythrocytes during different stages of ischemic insult, and makes blood viscosity somewhat less.

The Evans blue dilution method and ultrasound dopplerography were used to study the effect of nicergolin on the systemic and cerebral hemodynamics in 31 patients with dyscirculatory encephalopathy against the background of atherosclerotic lesions of the major head arteries. It was established that nicergolin reduces the arterial pressure, diminishes the minute blood volume, cardiac and stroke indices, increases the specific peripheral vascular resistance, the linear blood flow velocity prevailingly in the stenosed major head arteries, results in a regression of the subjective and objective neurological symptomatology. Considering the cardiodepressive effect of nicergolin, this agent is indicated in patients with the hyperkinetic type of the systemic hemodynamics.

Evans blue dilution and ultrasound dopplerography was used to examine 170 atherosclerosis patients with initial manifestations of insufficient cerebral blood supply (77 patients) and transient disorders of the cerebral blood circulation (93 patients) with occlusive and stenotic involvements of the major brain arteries. The authors revealed characteristic aspects of responses of the systemic-hemodynamic mechanisms in initial manifestations of insufficiency of the cerebral blood supply and transient disorders of the cerebral blood circulation with stenosis and occlusions of the major brain arteries and without involvement of the brain vessels. Treatment aspects are discussed.

Thirty-eight atherosclerotic patients with chronic disorders of the cerebral circulation (CDCC) received 300 mg of complamin by intravenous drip. The clinical signs of vasodilation were noted at 5-15 min after the initiation of infusion whereas following it the findings observed included a significant reduction in the kinetic parameters of the myocardium and globular blood volume, an elevation in the peripheral vascular resistance and tone of the cerebral hemisphere vessels, a decrease in the pulse vascular resistance and tone of the cerebral hemisphere vessels, a decrease in the pulse blood-filling of the left carotid bed and deterioration of intracerebral venous congestion. Complamin is recommended for use to improve the rheological properties of the blood and microcirculation in patients with CDCC with elevated or normal myocardial contractility. Its application should be avoided in patients with low cardiac output and heart failure, in cases of labile arterial pressure and vascular dystonia with marked pulse variations in the cerebral vessels and also when the blood return to the cerebral veins is impeded.