1. Localization of the orexin system in the gastrointestinal tract of fallow deer.
- Author
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Dall'Aglio C, Pascucci L, Mercati F, Boiti C, and Ceccarelli P
- Subjects
- Abomasum, Animals, Deer metabolism, Duodenum cytology, Duodenum innervation, Enteric Nervous System cytology, Enteric Nervous System metabolism, Epithelial Cells metabolism, Female, Ganglia, Autonomic cytology, Ganglia, Autonomic metabolism, Gastrointestinal Tract cytology, Gastrointestinal Tract innervation, Gastrointestinal Tract metabolism, Intestinal Mucosa cytology, Intestinal Mucosa metabolism, Lower Gastrointestinal Tract cytology, Lower Gastrointestinal Tract innervation, Male, Orexin Receptors, Orexins, Organ Specificity, Stomach cytology, Deer anatomy & histology, Duodenum metabolism, Gastric Mucosa metabolism, Intracellular Signaling Peptides and Proteins metabolism, Lower Gastrointestinal Tract metabolism, Neuropeptides metabolism, Receptors, G-Protein-Coupled metabolism, Receptors, Neuropeptide metabolism
- Abstract
The aim of the present study was to investigate by immunohistochemistry the presence and distribution of the orexin system in the stomach and gut of fallow deer. Abundant orexin A-positive cells were localized in the middle and basal portions of the mucosal glands of the cardial and fundic regions of the stomach. In the same gastric areas, orexin B-positive cells were also found, mainly localized in the basal portion of glands. In the intestinal tract, orexin-containing cells were occasionally found in the duodenal epithelium and in the rectal intestinal glands. Immunoreactivity for orexin receptors, type 1 and 2 (OX1R and OX2R), was not detected in the same stomach regions. OX1R-immunopositivity was observed in the enteric neuron ganglia localized in the submucosal and muscular intestinal layers, while OX2R-immunopositivity was found close in contact with the cytoplasmic membrane of epithelial cells in the small intestine., (Copyright © 2011 Elsevier GmbH. All rights reserved.)
- Published
- 2012
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