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Background: Crohn's disease is characterized by damage to the intestines, which can affect the gastrointestinal tract (from the mouth to the anus). The risks of Crohn's disease appear to be linked to changes in the gut Macrobiota or disturbances in the mucosa and intestinal genetics. Objectives: We aimed to study the implication of appendectomy on the risk of the development of Crohn's disease in the western Algeria population. Methods: It was a retrospective analytical study of 403 patients from 2007 to 2020 carried out at the level of general surgery departments and university hospitals in western Algeria. Results: Four hundred three CD patients were included in our study. Among them, 81 cases have undergone an appendectomy. The average age was 36.88 ± 12.47, and the most affected location was the ileocecal location with P = 0.001. However, no significant association was noted between appendectomy andCDphenotype. Most of them suffered from constipation (P< 0.0001), came from urban areas, and presented extra-intestinal manifestations (P < 0.0001). Treatment of the disease was often medical, while 68 cases of the 81 appendectomized patients underwent surgery. Early relapse of CD was also observed in appendectomized patients with P = 0.035. Moreover, many complications (anal fissures, anal fistula) were also noted but with no significant association. Conclusions: From our results, it appears that Crohn's disease risk can be associated with a previous appendectomy and mainly manifested by ileocecal localization and constipation. [ABSTRACT FROM AUTHOR]

The objective of this study was to evaluate the effects of subchronic exposure to NaMBS (90 days), on the quantitative hemogram and the thymus histology spleen and stomach in Wistar rats. The study involved 24 female Wistar rats, receiving increasing concentrations of 0.25%, 1% and 4% of NaMBS in drinking water, for 90 days compared to the control group receiving drinking water without NaMBS. At the end of the experiment, the control and experimental rats were sacrificed, the blood and organs were removed and the hematological parameters were assayed. The thymus, spleen and stomach were used for histological study. In all cases a value p <0.05 was considered significant. The results obtained show that, the group receiving 4% of NaMBS showed a significant decrease in the number of red blood cells and hemoglobin (p< 0.05), an increase in the number of white blood cells (p< 0.01) and the number of platelets were observed. The doses of 1% and 4% cause statistically significant changes of the erythrocyte indices (MCV, MCHC, MCHC); and of the leukocyte formula (lymphocytes, monocytes, granulocytes), in comparison with the control group. Hyperplasia of the spleen and stomach in animals treated with 1% and 4% of NaMBS, was observed in comparison with those of control animals. In addition, histological examination revealed hyperplasia of the white pulp and inflammation of the spleen, in rats treated with 4% of NaMBS and inflammation of the gastric mucosa, in the groups receiving 1% and 4% of NaMBS dose. The results obtained indicate that, the subchronic ingestion of NaMBS above the ADI, seems to cause alterations in some hematological parameters such as splenic and gastric histo-alterations in Wistar rats. [ABSTRACT FROM AUTHOR]