1. A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies.
- Author
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Sambataro, Gianluca, Ferrara, Chiara Alfia, Spadaro, Carla, Torrisi, Sebastiano Emanuele, Vignigni, Giovanna, Vancheri, Ada, Muscato, Giuseppe, Del Papa, Nicoletta, Colaci, Michele, Malatino, Lorenzo, Palmucci, Stefano, Cavagna, Lorenzo, Zanframundo, Giovanni, Ferro, Francesco, Baldini, Chiara, Sambataro, Domenico, and Vancheri, Carlo
- Subjects
INTERSTITIAL lung diseases ,MYALGIA ,OPTIMISM ,IMMUNOGLOBULINS ,CONNECTIVE tissue diseases ,MYOSITIS - Abstract
In this study, it was found that myositis-specific and myositis-associated antibodies (MSAs and MAAs) improved the recognition of idiopathic inflammatory myopathies (IIMs) in interstitial lung disease (ILD) patients. The objective of this study is to propose a clinical method to evaluate myalgia in respiratory settings as a possible tool for the recognition of MSA/MAA positivity in ILD patients. We prospectively enrolled 167 ILD patients with suspected myositis, of which 63 had myalgia evoked at specific points (M+ILD+). We also enrolled in a 174 patients with only myalgia (M+ILD-) in a rheumatological setting. The patients were assessed jointly by rheumatologists and pulmonologists and were tested for autoantibodies. M+ILD+ patients were positive for at least one MAA/MSA in 68.3% of cases, as were M-ILD+ patients in 48.1% of cases and M+ILD- patients in 17.2% of cases (p = 0.01 and <0.0001, respectively). A diagnosis of IIM was made in 39.7% of M+ILD+ patients and in 23.1% of the M-ILD+ group (p = 0.02). Myalgia was significantly associated with positivity for MSA/MAAs in ILD patients (p = 0.01, X
2 : 6.47). In conclusion, myalgia in ILD patients with suspected myositis is associated with MSA/MAA positivity, and could support a diagnosis of IIM. A significant proportion of M+ILD- patients also had MSA/MAA positivity, a phenomenon warranting further study to evaluate its clinical meaning. [ABSTRACT FROM AUTHOR]- Published
- 2022
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