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Objectives: To evaluate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) values and the severity of coronary lesions at angiography in unstable angina patients with preserved left ventricular function. Methods: A total of 133 patients with primary diagnosis of unstable angina were enrolled into this study. NT-proBNP level was determined before the angiography and Gensini score, a measurement of extent of myocardial ischemia, was calculated after the angiography by experienced cardiologists. Patients with >50% stenosis of the left main or 75% stenosis of one or more coronary branches with diameter >2 mm were defined as “angiography positive” and turned to percutaneous coronary intervention. Results: There was a significant difference of circulating NT-proBNP level between the angiography positive and negative groups and the median NT-proBNP values were 367.5 pg/mL and 112 pg/mL, respectively (P < 0.001). A significant correlation was observed between log NT-proBNP and log Gensini score (P < 0.001). NT-proBNP level was a predictor of angiography positive result and the area under the receiver operating characteristic curve was 0.776 (95% CI 0.693–0.858). Conclusions: NT-proBNP level was found to be higher with the severity of myocardial ischemia. However, the ability of NT-proBNP to identify clinically significant angiographic lesions was moderate. (J Interven Cardiol 2012;25:126–131)

Objective The new biochemical indicator ischaemia modified albumin (IMA) cmay reflect the degree of myocardial ischaemia sensitively. We studied the variation of ischaemia as assessed by the change in level of IMA during the transient myocardial ischaemia due to balloon dilation during PCI. Methods Thirty one patients who were ready to undergo PCI were randomly selected. The IMA was detected with ACB (albumin cobalt binding) test before and after saccule dilation. To study if the IMA level after saccule dilation was high than before, and if the change had statistical significance, we used Paired-Sample T test in the SPSS statistics software. Results The data was signed by means of (mean±SD), the IMA level before saccule dilation was (77.03±13.82) U/ml and after was (90.06±23.58) U/ml. To analyse the data, we found the IMA level after dilation was higher than that before, and the difference had statistical significance (p=0.011, obviously Conclusion Balloon dilation was an ideal model of transient myocardial ischaemia which can be reflected by the change of the IMA level. We were able to cofirm the value of IMA as a new biochemical indicator on the detection of myocardial ischaemia during balloon dilation.

Objective Saccule predilation has been an essential device during percutaneous coronary intervention (PCI). We evaluate the ischaemic preconditioning effect of repeated myocardial ischaemia during predilations. Methods Thirty one patients who were ready to undergoing PCI were randomly selected. And we choosed the new biochemical indicator ischaemia modified albumin (IMA) as a sensitive index, and the IMA were detected with ACB (albumin cobalt binding) test before saccule dilations, after dilations and after stent implantation. To analyse the data, we used Paired-Sample T test in the SPSS statistics software to investigate the change of the IMA level, and if the change had statistical significance. Results The data was signed by means of (mean±SD), the IMA level were (77.03±13.82) U/ml, (90.06±23.58) U/ml and (82.43±21.87) U/ml before saccule predilation, after predilations and after stent implantation. We found the IMA level was lower after stent implantation than that after saccule predilations, and the variance had statistical significance (p=0.031, 0.05). Conclusion The degree of myocardial ischaemia was relieved during saccule predilations, even can neutralise the ischaemic effect that dilations causing. We can suppose the intrinsic mechanism which we called ischaemic preconditioning effect that pretected the myocardium.