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Your search keyword '"Patricia L. Bononi"' showing total 2 results
Start Over Author "Patricia L. Bononi" Topic internal medicine
2 results on '"Patricia L. Bononi"'

1. The oxytocin secretory response during suckling in the hypoosmolar lactating rat

Author

Janine E. Janosky, Janet A. Amico, and Patricia L. Bononi

Subjects
endocrine system, medicine.medical_specialty, Neuropeptide, Oxytocin, Rats, Sprague-Dawley, Reference Values, Internal medicine, Lactation, Animals, Medicine, Deamino Arginine Vasopressin, Secretion, Molecular Biology, Post partum, business.industry, General Neuroscience, Osmolar Concentration, Radioimmunoassay, medicine.disease, Animals, Suckling, Rats, Endocrinology, medicine.anatomical_structure, Female, Neurology (clinical), business, Hyponatremia, Breast feeding, hormones, hormone substitutes, and hormone antagonists, Developmental Biology, medicine.drug
Abstract

Secretion of oxytocin into the peripheral circulation of rats is stimulated by suckling and inhibited by hypoosmolality. We compared the oxytocin secretory response to suckling in 1 week post partum lactating rats rendered hyponatremic for 48 h to matched lactating normonatremic cohorts. Pituitary content of oxytocin and peripheral oxytocin secretory responses to suckling were equivalent in normonatremic and hyponatremic animals. We conclude that induction of sustained hyponatremia for 48 h does not inhibit suckling-induced oxytocin release in lactating rats.

Published
1993
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2. Flow cytometric analysis of growth hormone-secreting pituitary adenomas

Author

Janet A. Amico, Janine E. Janosky, Patricia L. Bononi, McCoy Jp, and A J Martinez

Subjects
Adenoma, Adult, Male, medicine.medical_specialty, Pathology, Adolescent, Endocrinology, Diabetes and Metabolism, Aneuploidy, Biology, Growth hormone, Flow cytometry, Endocrinology, Pituitary adenoma, Internal medicine, medicine, Endocrine system, Humans, Pituitary Neoplasms, Aged, Ploidies, medicine.diagnostic_test, Clinical course, DNA, Neoplasm, Middle Aged, medicine.disease, Flow Cytometry, Prolactin, Growth Hormone, Female, Ploidy
Abstract

Flow cytometric DNA analysis was performed on samples of paraffin-embedded and fresh adenomatous pituitary tissue removed from 16 patients with growth hormone (GH)-secreting pituitary adenomas. Histograms consistent with aneuploidy were found in 5 of 16 patients. The flow cytometric patterns on fresh and paraffin-embedded tissues yielded similar results. Ploidy did not correlate with the clinical course or the endocrine profiles in these patients. We conclude that flow cytometric DNA analysis can detect aneuploidy in adenomatous pituitary tissue, but it does not predict the clinical course of GH-secreting adenomas.

Published
1994

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