1. Changes in Serum Fibroblast Growth Factor 23 in Patients With Acute Myocardial Infarction
- Author
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Yoshihiro Takeda, Hideaki Morita, Michishige Ozeki, Koichi Sohmiya, Shuichi Fujita, Kensaku Shibata, Nobukazu Ishizaka, Hideaki Takahashi, Tomohiro Fujisaka, Masaaki Hoshiga, and Junko Tamaki
- Subjects
0301 basic medicine ,Fibroblast growth factor 23 ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Myocardial Infarction ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Internal medicine ,medicine ,Creatine Kinase, MB Form ,Humans ,cardiovascular diseases ,Myocardial infarction ,Ejection fraction ,biology ,business.industry ,Percutaneous coronary intervention ,Stroke Volume ,General Medicine ,Stroke volume ,medicine.disease ,Fibroblast Growth Factors ,Fibroblast Growth Factor-23 ,stomatognathic diseases ,030104 developmental biology ,Echocardiography ,Conventional PCI ,Cohort ,Cardiology ,biology.protein ,Creatine kinase ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Fibroblast growth factor 23 (FGF23) induces cardiac remodeling. We investigated the changes in serum FGF23 levels in patients diagnosed with acute myocardial infarction (AMI).Methods and Results:A total of 44 patients diagnosed with AMI were included in the current study. All patients underwent emergency percutaneous coronary intervention (PCI). The median of peak creatine kinase (CK) and CKMB values was 1,816 U/L and 159 U/L, respectively. Serum levels of FGF23, calcium, and inorganic phosphate (iP) were measured before PCI, and on days 1, 3, 5, 7 after PCI. Serum FGF23 levels showed a slight, but significant decrease on days 1 and 3 after PCI, and a 1.5- and 2.0-fold increase on days 5 and 7, respectively, after PCI. As compared with propensity score-matched patients without AMI, serum FGF23 was significantly lower among the current cohort of AMI patients. In 22 subjects who underwent a follow-up echocardiographic examination at 6 months after the onset of AMI, the log-transformed relative increase in FGF23 on day 7 significantly and negatively correlated with changes between LVEF on admission and that at 6 months afterward. Conclusions After a slight decrease on days 1 and 3 after admission, serum FGF23 increased significantly on days 5 and 7. The underlying mechanism and potential clinical importance of these observations require further investigation.
- Published
- 2018
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