1. Lanthionine, a novel uremic toxin, in the vascular calcification of chronic kidney disease: The role of proinflammatory cytokines
- Author
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Domenico Russo, Vittoria D'Esposito, Annapaola Coppola, Carmela Vigorito, Pietro Formisano, Luigi Russo, Dario Bruzzese, Patrizia Lombari, Diego Ingrosso, Alessandra F. Perna, Perna, A., Russo, L., D'Esposito, V., Formisano, P., Bruzzese, D., Vigorito, C., Coppola, A., Lombari, P., Russo, D., and Ingrosso, D.
- Subjects
0301 basic medicine ,Eotaxin ,Male ,medicine.medical_treatment ,030232 urology & nephrology ,urologic and male genital diseases ,Gastroenterology ,chemistry.chemical_compound ,0302 clinical medicine ,Chronic kidney disease ,Biology (General) ,Spectroscopy ,hemodialysis ,Alanine ,Interleukin ,General Medicine ,female genital diseases and pregnancy complications ,Computer Science Applications ,Chemistry ,Female ,Hemodialysis ,Hemodialysi ,Agatston score ,Lanthionine ,Glomerular Filtration Rate ,Human ,Adult ,medicine.medical_specialty ,QH301-705.5 ,Sulfide ,Renal function ,Sulfides ,Article ,Catalysis ,Proinflammatory cytokine ,Inorganic Chemistry ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Physical and Theoretical Chemistry ,Renal Insufficiency, Chronic ,Vascular Calcification ,Molecular Biology ,QD1-999 ,Cytokine ,business.industry ,Organic Chemistry ,Biomarker ,medicine.disease ,cytokines ,030104 developmental biology ,chemistry ,business ,Biomarkers ,Kidney disease - Abstract
Vascular calcification (VC) is a risk factor for cardiovascular events and mortality in chronic kidney disease (CKD). Several components influence the occurrence of VC, among which inflammation. A novel uremic toxin, lanthionine, was shown to increase intracellular calcium in endothelial cells and may have a role in VC. A group of CKD patients was selected and divided into patients with a glomerular filtration rate (GFR) of <, 45 mL/min/1.73 m2 and ≥45 mL/min/1.73 m2. Total Calcium Score (TCS), based on the Agatston score, was assessed as circulating lanthionine and a panel of different cytokines. A hemodialysis patient group was also considered. Lanthionine was elevated in CKD patients, and levels increased significantly in hemodialysis patients with respect to the two CKD groups, in addition, lanthionine increased along with the increase in TCS, starting from one up to three. Interleukin IL-6, IL-8, and Eotaxin were significantly increased in patients with GFR <, 45 mL/min/1.73 m2 with respect to those with GFR ≥ 45 mL/min/1.73 m2. IL-1b, IL-7, IL-8, IL-12, Eotaxin, and VEGF increased in calcified patients with respect to the non-calcified. IL-8 and Eotaxin were elevated both in the low GFR group and in the calcified group. We propose that lanthionine, but also IL-8 and Eotaxin, in particular, are a key feature of VC of CKD, with possible marker significance.
- Published
- 2021