Author: "Diane Barker" / Topic: internal medicine - Searchworks@Jio Institute Digital Library Search Results

33 results on '"Diane Barker"'

1. Outcomes of Patients Who Have Incidental Non-Sustained Ventricular Tachycardia Identified on Cardiac Implantable Electronic Device Interrogation

Author: Thanh Phan, Aditya Narain, Daniel Darlington, Fozia Z. Ahmed, Chun Shing Kwok, Diane Barker, Caterina Liggett-Wright, and Joseph Mayer
Subjects: Medication review, Clinical audit, medicine.medical_specialty, business.industry, cardiac implantable devices, 030204 cardiovascular system & hematology, Ventricular tachycardia, medicine.disease, outcomes, 03 medical and health sciences, 0302 clinical medicine, Sustained ventricular tachycardia, Internal medicine, Shock (circulatory), Cardiology, Medicine, 030212 general & internal medicine, medicine.symptom, non-sustained ventricular tachycardia, business
Abstract: Background: Non-sustained ventricular tachycardia (NSVT) is an arrhythmia prevalent in both structurally normal and abnormal hearts. Methods: We conducted a single-center retrospective clinical audit of patients followed-up in a device clinic with one or more incidental NSVT episodes recorded on their device between November 2017 and August 2018 and followed up patients for outcomes until January 2019. Results: A total of 83 patients were included in the analysis with one or more episodes of NSVT on device interrogation. Those identified to have NSVT were more likely to be male (74.7%) and there was a mean of 14.2 beats per episode and a mean of 3.7 episodes for each patient. Only 24.7% of patients had electrolytes checked within 4 weeks of episode detection and 18.3% had an echocardiogram post-episode. The majority of patients (73.5%) were followed up again in the pacing clinic but had no changes in medication, or other management implemented. In terms of outcomes, 81.7% of patients had no admission to hospital, mortality, or shock during the follow-up period. Conclusions: Most patients who developed NSVT did not have an extra follow-up, medication review, or investigation. Despite this, outcomes such as admission, shock, or death were uncommon.
Published: 2021
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2. Prevalence, Outcomes, and Costs According to Patient Frailty Status for 2.9 Million Cardiac Electronic Device Implantations in the United States

Author: Rahul Bhardwaj, Mohamed O. Mohamed, Annabelle Santos Volgman, Chun Shing Kwok, Mamas A. Mamas, Ashish Patwala, Parikshit S. Sharma, Diane Barker, and Muhammad Rashid
Subjects: Male, Pacemaker, Artificial, medicine.medical_specialty, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Prevalence, Humans, Medicine, 030212 general & internal medicine, Hospital Costs, Aged, Retrospective Studies, Framingham Risk Score, Frailty, business.industry, Arrhythmias, Cardiac, RC666, Prognosis, United States, Defibrillators, Implantable, Frailty assessment, Survival Rate, Costs and Cost Analysis, Female, National database, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract: Background: Little is known about the impact of frailty on length of stay (LOS), cost and inhospital procedural outcomes of cardiac implantable electronic device (CIED) implantation procedures.\ud \ud Methods: All de novo CIED implantations recorded in the United States (2004-2014) from a national database were stratified according to the Hospital Frailty Risk Score into low-risk (LRF;15) frailty groups. Regression analyses were performed to assess the association between frailty and procedural outcomes.\ud \ud Results: Out of 2,902,721 implantations, LRF, IRF and HRF were 77.6%, 21.2% and 1.2%, respectively. Frailty increased from 2004 to 2014 (IRF: 14.3% to 32.5%, HRF: 0.2% to 3.3%). Complications were 2-3 fold higher in the IRF and HRF groups, while all-cause mortality was 4 to 9-fold higher in IRF (2.9%) and HRF (5.3%) groups, depending on the type of CIED (p
Published: 2019

3. The role of the Tei index in assessing for cardiotoxicity from anthracycline chemotherapy: a systematic review

Author: Sadie Bennett, Arzu Cubukcu, Chun Wai Wong, Timothy Griffith, Cheryl Oxley, Diane Barker, Simon Duckett, Duwarakan Satchithananda, Ashish Patwala, Grant Heatlie, Chun Shing Kwok, Griffith Timothy, Oxley Chery, Barker Diane, Duckett Simon, Satchithananda Duwarakan, Patwala Ashish, and Heatlie Grant
Subjects: Cardiac function curve, medicine.medical_specialty, Anthracycline, medicine.medical_treatment, MEDLINE, Diastole, cardiotoxicity, Review, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Diseases of the circulatory (Cardiovascular) system, Radiology, Nuclear Medicine and imaging, myocardial performance index, Subclinical infection, Advanced and Specialized Nursing, Chemotherapy, Cardiotoxicity, Ejection fraction, Radiological and Ultrasound Technology, business.industry, R735, 2d echocardiography, R1, tei index, RC666-701, Cardiology, business, RA
Abstract: Background Anthracycline agents are known to be effective treatments for solid tumors and hematological malignancies. Although these agents improve survival, their use is associated with cardiotoxic effects, which most commonly manifests as left ventricular systolic dysfunction (LVSD). As such guidelines recommend the periodic assessment of left ventricular ejection fraction (LVEF). However, as diastolic dysfunction likely proceeds systolic impairment in this setting, the role of Tei index may offer additional benefit in detecting subclinical LVSD. Methods We conducted a systematic review to investigate the evidence for the use of Tei index in assessing for subclinical cardiotoxicity in patients receiving anticancer agents. A search of Medline and EMBASE was performed and relevant studies were reviewed and narratively synthesized. Results A total of 13 studies were included with a total of 800 patients (mean age range 46-62 years, percentage of male participants ranged from 0%-86.9%). An increase in Tei index was observed in 11 studies, which suggesting a decline in cardiac function following chemotherapy. Out of these, 6 studies indicated that the Tei index is a useful parameter in predicting cardiotoxic LVSD. Furthermore, 5 studies indicated Tei index to be superior to LVEF in detecting subclinical cardiotoxicity. Conclusions While there are some studies that suggest that Tei index may be a useful indicator in assessing for subclinical anthracycline related cardiotoxicity, the findings are inconsistent so more studies are needed before the evaluation of Tei index should be performed routinely in patients receiving chemotherapy.
Published: 2021

4. Sex Disparities in the Choice of Cardiac Resynchronization Therapy Device: An Analysis of Trends, Predictors, and Outcomes

Author: Margo Minissian, Purvi Parwani, Glen P. Martin, Muhammad Rashid, Mamas A. Mamas, Harriette G.C. Van Spall, Donah Zachariah, Tahmeed Contractor, Ashish Patwala, Mohamed O. Mohamed, and Diane Barker
Subjects: Male, medicine.medical_specialty, Pacemaker, Artificial, genetic structures, Databases, Factual, Heart Diseases, medicine.medical_treatment, Cardiac resynchronization therapy, Disease, 030204 cardiovascular system & hematology, Logistic regression, Q1, Medicare, Odds, Cardiac Resynchronization Therapy, 03 medical and health sciences, 0302 clinical medicine, Hospitals, Urban, Sex Factors, Internal medicine, Neoplasms, medicine, Humans, 030212 general & internal medicine, cardiovascular diseases, Renal Insufficiency, Healthcare Disparities, Sex Distribution, Aged, Aged, 80 and over, business.industry, Age Factors, Atrial fibrillation, Odds ratio, Middle Aged, medicine.disease, equipment and supplies, Confidence interval, United States, Defibrillators, Implantable, Hospital Bed Capacity, cardiovascular system, H1, Female, Implant, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology
Abstract: Background There is limited evidence on the influence of sex on the decision to implant a cardiac resynchronization therapy device with pacemaker (CRT-P) or defibrillator (CRT-D) and the existence of sex-dependent differences in complications that may affect this decision. Methods All patients undergoing de novo CRT implantation (2004-2014) in the United States National Inpatient Sample were included and stratified by device type (CRT-P and CRT-D). Multivariable logistic regression models were conducted to assess the association of female sex with receipt of CRT-D and periprocedural complications. Results Out of 400,823 weighted CRT procedural records, the overall percentages of women undergoing CRT-P and CRT-D implantations were 41.5% and 27.8%, respectively, and these percentages increased compared with men over the study period. Women were less likely to receive CRT-D (odds ratio 0.66, 95% confidence interval 0.64-0.67), and this trend remained stable throughout the study period (P = 0.06). Furthermore, compared with men, women were associated with increased odds of procedure-related complications (bleeding, thoracic, and cardiac) in the CRT-D group but not in the CRT-P group. Factors such as atrial fibrillation, malignancies, renal failure, advanced age (> 60 years), and admission to nonurban/small hospitals favoured the receipt of CRT-P over CRT-D, whereas history of ischemic heart disease, cardiac arrest ,or ventricular arrhythmias favoured the receipt of CRT-D over CRT-P. Conclusions Women were associated with persistently reduced odds of receipt of CRT-D compared with men over an 11-year period. This study identifies important factors that predict the choice of CRT device offered to patients in the United States.
Published: 2019

5. Trends of Sex Differences in Outcomes of Cardiac Electronic Device Implantations in the United States

Author: Mamas A. Mamas, Annabelle Santos Volgman, Glen P. Martin, Ashish Patwala, Diane Barker, Mohamed O. Mohamed, Parikshit S. Sharma, Chun Shing Kwok, Muhammad Rashid, and Tahmeed Contractor
Subjects: Male, medicine.medical_treatment, 030204 cardiovascular system & hematology, outcomes, Cardiac Resynchronization Therapy, 0302 clinical medicine, Risk Factors, Cause of Death, defibrillators, Prevalence, 030212 general & internal medicine, Hospital Mortality, Aged, 80 and over, treatment, Incidence (epidemiology), Incidence, cardiac resynchronization, Middle Aged, RC666, Hospitalization, Survival Rate, pacemakers, Cohort, Female, Cardiology and Cardiovascular Medicine, trends, medicine.medical_specialty, Cardiac resynchronization therapy, Risk Assessment, Odds, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, sex, Humans, Cardiac Resynchronization Therapy Devices, Adverse effect, Aged, Retrospective Studies, Inpatients, business.industry, Retrospective cohort study, Arrhythmias, Cardiac, R1, Confidence interval, United States, Cardiac devices, business, RA
Abstract: Background The disparity in outcomes of cardiac electronic device implantations between sexes has been previously demonstrated in device-specific cohorts (eg, implantable cardioverter-defibrillators [ICDs]). However, it is unclear whether sex differences are present with all types of cardiac implantable electronic devices (CIEDs) and, if so, what the trends of such differences have been in recent years. Methods With the use of the National Inpatient Sample, all hospitalizations from 2004 to 2014 for de novo implantation of permanent pacemakers, cardiac resynchronization therapy with or without a defibrillator, and ICDs were analyzed to examine the association between sex and in-hospital acute complications of CIED implantation. Results Out of 2,815,613 hospitalizations for de novo CIED implantation, 41.9% were performed on women. Women were associated with increased adjusted odds (95% confidence interval) of adverse procedural complications (major adverse cardiovascular complications: 1.17 [1.16-1.19]; bleeding: 1.13 [1.12-1.15],-thoracic: 1.42 [1.40-1.44]; cardiac: 1.44 [1.38-1.50]), whereas the adjusted odds of in-hospital all-cause mortality compared with men was 0.96 (0.94-1.00). The odds of adverse complications in the overall CIED cohort were persistently raised in women throughout the study period, whereas similar odds of all-cause mortality across the sexes were observed throughout the study period. Conclusion In a national cohort of CIED implantations we demonstrate that women are at an overall higher risk of procedure-related adverse events compared with men, but not at increased risk of all-cause mortality. Further studies are required to identify procedural techniques that would improve outcomes among women undergoing such procedures.
Published: 2019

6. Early Readmissions After Acute Myocardial Infarction

Author: Chun Wai Wong, Adrian Shufflebotham, Tamseel Fatima, Hannah Shufflebotham, Luke Brindley, Ashish Pawala, Diane Barker, Mamas A. Mamas, Grant Heatlie, and Chun Shing Kwok
Subjects: Male, medicine.medical_specialty, Acute coronary syndrome, Chest Pain, Time Factors, medicine.medical_treatment, Myocardial Infarction, 030204 cardiovascular system & hematology, Chest pain, Coronary Angiography, Patient Readmission, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Risk Factors, Lower respiratory tract infection, Internal medicine, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, cardiovascular diseases, Hospital Mortality, Aged, Retrospective Studies, business.industry, Incidence, Percutaneous coronary intervention, Retrospective cohort study, medicine.disease, RC666, R1, United Kingdom, Survival Rate, Heart failure, Cardiology, cardiovascular system, Female, Myocardial infarction diagnosis, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract: This study aims to evaluate the rate, predictors, and causes of 30-day readmissions in a single tertiary hospital in the United Kingdom. We conducted a retrospective study of all patients admitted between 2012 and 2014 with a diagnosis of acute myocardial infarction, who were in the Myocardial Infarction National Audit Project register. Data on patient demographics, comorbidities, care received, and in-hospital mortality were collected. Rates of 30-day readmission and causes of readmission were evaluated. Univariate and multiple logistic regressions were used to identify predictors of all-cause, cardiac, and noncardiac readmission. A total of 1,869 patients were included in the analysis and 171 had an unplanned readmission with 30 days (9%). Noncardiac problems represented half of all readmissions with the dominant cause noncardiac chest pain (50%). A variety of other noncardiac causes for readmission were identified and the most common were lower respiratory tract infection (4.3%), gastrointestinal problems (4.9%), bleeding (3.7%), dizziness, syncope, or fall (3.0%), and pulmonary embolus (2.4%). For cardiac causes of readmissions, common causes included acute coronary syndrome (17.1%), stable angina (11.6%), and heart failure (9.8%). Readmitted patients were more likely to be older, anemic, and less likely to receive coronary angiogram and percutaneous coronary intervention. After adjustment, the only predictor of all-cause readmission was older age. For noncardiac readmission, previous myocardial infarction was associated with significantly fewer readmissions. Our results suggest that early readmission after discharge with diagnosis of acute myocardial infarction is common. Chest pain is the most frequent cause of readmission, and interventions to reduce noncardiac chest pain admissions are needed.
Published: 2017

7. Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review

Author: Fozia Z Ahmed, Ashish Patwala, Colin Dominic Chue, Chun Wai Wong, Diane Barker, Mamas A. Mamas, Colin Cunnington, Chun Shing Kwok, and Amir Zaidi
Subjects: medicine.medical_specialty, medicine.medical_treatment, MEDLINE, 030204 cardiovascular system & hematology, Ventricular tachycardia, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Ventricular fibrillation, implanted cardiac defibrillators, business.industry, Incidence (epidemiology), Mortality rate, Arrhythmias, Cardiac, Equipment Design, medicine.disease, Implantable cardioverter-defibrillator, RC666, Surgery, Defibrillators, Implantable, Death, Sudden, Cardiac, Systematic review, Observational study, ventricular tachycardia, Cardiology and Cardiovascular Medicine, business, Complication
Abstract: Background:\ud Subcutaneous implantable cardioverter defibrillators (S-ICD) are an alternative to conventional transvenous implantable cardioverter defibrillators (TV-ICD) in patients not requiring pacing. We sought to define the efficacy and safety of S-ICD through literature review.\ud \ud Methods:\ud We searched MEDLINE and EMBASE for studies evaluating efficacy and safety outcomes among patients undergoing S-ICD implantation. We performed narrative synthesis and pooled efficacy and safety outcomes across studies.\ud \ud Results:\ud 16 studies were included with 5,380 participants (mean age range 33–56 years). Short-term follow-up data were available for 1670 subjects. The commonest complication was pocket infection, affecting 2.7% (range 0–19%). Other complications included delayed wound healing (0.6%), wound discomfort (0.8%), haematoma (0.4%) and lead migration (0.3%). A total of 3.8% (range 0–12%) of S-ICDs were explanted. The commonest reason for explant was pocket infection. Mortality rates in hospital (0.4%) and during follow-up (3.4% from 12 studies reporting, 2.1% per person-years) were low. The number of patients experiencing ventricular arrhythmia varied across studies from 0 to 12%. Overall shock efficacy for treatment of ventricular arrhythmias exceeded 96%. Inappropriate shocks affected 4.3% (range 0–15%) of patients and was most commonly caused by T-wave oversensing.\ud \ud Conclusions:\ud Although long-term randomised data are lacking, observational data suggest shock efficacy, peri-procedural and short-term complication rates of the S-ICD are similar to TV-ICD, making the S-ICD a suitable alternative in patients without an indication for pacing.
Published: 2017

8. Reduced cardiac functional reserve and quality of life in adults with GH deficiency

Author: David F. Goldspink, Lisa Sharp, Robert Moisey, Steve Orme, Lip-Bun Tan, Richard E. Clements, Nigel Lewis, and Diane Barker
Subjects: medicine.medical_specialty, Cardiac output, business.industry, Endocrinology, Diabetes and Metabolism, Hemodynamics, Cardiac reserve, Cardiorespiratory fitness, Stroke volume, Endocrinology, Blood pressure, Internal medicine, Heart rate, medicine, Systole, business
Abstract: Summary Introduction Patients with severe GH deficiency (GHD) suffer with a reduced quality of life in addition to diverse changes in cardiac size and performance. So far, the cardiac reserve ability to maintain the circulation during peak exercise has not been measured. We tested the hypothesis that patients with severe GHD have reduced cardiac reserve function compared with healthy controls and that this could explain, in part, their reduced quality of life. Aims Eighteen patients with severe GHD and an assessment of GHD in adults (AGHDA) score ≥11 (mean 20·0, range 12–25) were studied and compared with 18 age-, sex- and body mass index-matched healthy controls. Peak cardiac power and cardiorespiratory fitness were investigated using noninvasive haemodynamic measurements during maximal cardiopulmonary exercise testing. Results Compared with matched controls, the cardiac power of GHD patients during exercise to volitional exhaustion was significantly reduced by 15% (mean ± SD 4·4 ± 1·0 W vs. 5·2 ± 1·0 W, P = 0·02). Patients with GHD also had lower cardiac chronotropic reserve (peak heart rate 154 ± 21/min vs. 174 ± 11/min, P = 0·001) and a lower cardiac pressure-generating capacity (systolic blood pressure 160 ± 25 mmHg vs. 200 ± 15 mmHg, P
Published: 2009

9. A Mechanistic Investigation Into How Long-Term Resynchronization Therapy Confers Ongoing Cardiac Functional Benefits and Improved Exercise Capacity

Author: Nigel Lewis, Dominik Schlosshan, Chris Pepper, Diane Barker, and Lip-Bun Tan
Subjects: Adult, Male, Cardiac function curve, Cardiac output, medicine.medical_specialty, genetic structures, medicine.medical_treatment, Cardiac resynchronization therapy, Hemodynamics, Ventricular Function, Left, Double-Blind Method, health services administration, Internal medicine, medicine, Humans, cardiovascular diseases, Aged, Peak exercise, Heart Failure, Cross-Over Studies, Exercise Tolerance, business.industry, Respiration, Cardiac Pacing, Artificial, Middle Aged, Exercise capacity, medicine.disease, Myocardial Contraction, Crossover study, Heart failure, Exercise Test, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: The exact mechanisms underpinning the longer term benefits of cardiac resynchronization therapy (CRT) were not fully understood. It was still unclear whether there was any ongoing functional benefit conferred by the partial resynchronization of ventricular contraction. To resolve this, a randomized controlled double-blind crossover trial was conducted to investigate the impact of temporary cessation of CRT on cardiac function both at rest and during peak exercise. Fifteen patients with severe heart failure and a CRT device implanted at least 3 months previously were randomly assigned to have the CRT mode switched to either off or on during exercise tests with central hemodynamic measurements (including noninvasive cardiac output measured using rebreathing methods), then crossed over on separate days to the opposite CRT mode. There were no significant changes in hemodynamic variables at rest with either mode of CRT. When CRT was acutely turned off, there was 19% lower peak exercise cardiac power (2.10 +/- 0.46 vs 2.59 +/- 0.75 W; p0.005), 6% lower mean arterial pressure (92 +/- 12 vs 98 +/- 13 mm Hg; p0.05), and 11.5% lower peak cardiac output (10.4 +/- 1.9 vs 11.8 +/- 2.5 L/min; p0.05). Exercise capacity was also diminished with lower peak oxygen uptake (15.7 +/- 4.3 vs 17.2 +/- 4.9 ml/kg/min; p0.01) and shorter exercise duration (542 +/- 204 vs 587 +/- 212 seconds; p0.05). These changes were seen without differences in peak respiratory exchange ratio and peak systemic vascular resistance. In conclusion, these observations provided evidence that after CRT, left ventricular resynchronization continued to confer cardiac functional benefits manifest during peak exercise, but imperceptible at rest.
Published: 2009

10. Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis

Author: Iain Buchan, Mamas A. Mamas, Yoon K. Loke, Chun Shing Kwok, James Nolan, Adrian Morley-Davies, Ashish Patwala, Duwarakan Satchithananda, Phyo K. Myint, Rhys Beynon, Diane Barker, and Muhammad Rashid
Subjects: Adult, Male, medicine.medical_specialty, Heart block, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Cardiac Conduction System Disease, Internal medicine, Risk of mortality, Medicine, Humans, 030212 general & internal medicine, Myocardial infarction, PR interval, Atrioventricular Block, Stroke, Aged, Brugada Syndrome, Aged, 80 and over, business.industry, Atrial fibrillation, Middle Aged, medicine.disease, Prognosis, R1, Observational Studies as Topic, Heart failure, Relative risk, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Objective First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcomes. This study aims to determine if prolonged PR interval is associated with adverse cardiovascular outcomes and mortality. Methods We searched MEDLINE and EMBASE for studies that evaluated clinical outcomes associated with prolonged and normal PR intervals. Relevant studies were pooled using random effects meta-analysis for risk of mortality, cardiovascular mortality, heart failure, coronary heart disease, atrial fibrillation and stroke or transient ischaemic attack (TIA). Sensitivity analyses were performed considering the population type and the use of adjustments. Results Our search yielded 14 studies that were undertaken between 1972 and 2011 with 400 750 participants. Among the studies that adjusted for potential confounders, the pooled results suggest an increased risk of mortality with prolonged PR interval risk ratio (RR) 1.24 95% CI 1.02 to 1.51, five studies. Prolonged PR interval was associated with significant risk of heart failure or left ventricular dysfunction (RR 1.39 95% CI 1.18 to 1.65, three studies) and atrial fibrillation (RR 1.45 95% CI 1.23 to 1.71, eight studies) but not cardiovascular mortality, coronary heart disease or myocardial infarction or stroke or TIA. Similar observations were recorded when limited to studies of first-degree heart block. Conclusions Data from observational studies suggests a possible association between prolonged PR interval and significant increases in atrial fibrillation, heart failure and mortality. Future prospective studies are needed to confirm the relationships reported, consider possible mechanisms and define the optimal monitoring strategy for such patients.
Published: 2015

11. CRT improves the exercise capacity and functional reserve of the failing heart through enhancing the cardiac flow- and pressure-generating capacity

Author: D. Schlosshan, Gordon H. Williams, Diane Barker, Lip-Bun Tan, Chris Pepper, and C. Morley
Subjects: Male, Cardiac function curve, Pacemaker, Artificial, medicine.medical_specialty, Cardiac output, QRS complex, Oxygen Consumption, Heart Rate, Internal medicine, medicine, Health Status Indicators, Humans, Prospective Studies, cardiovascular diseases, Cardiac Output, Aged, Heart Failure, Exercise Tolerance, business.industry, Cardiac Pacing, Artificial, Middle Aged, Exercise capacity, medicine.disease, Blood pressure, Heart failure, Circulatory system, Cohort, Exercise Test, Quality of Life, cardiovascular system, Cardiology, Female, Vascular Resistance, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, circulatory and respiratory physiology
Abstract: Background: While information on how cardiac resynchronisation therapy (CRT) affects cardiac performance at rest is readily available, the mechanisms whereby CRT alters cardiac function during maximal exercise are unclear. Aims: We examined the medium-term effects of CRT on cardiac and physical functional reserve of patients with severe heart failure (CHF) and prolonged QRS duration. Methods: Seventeen consecutive patients with severe CHF (NYHA III–IV) and widened QRS underwent maximal cardiopulmonary exercise testing with non-invasive central haemodynamic measurements before and 6–8 weeks after CRT pacemaker implantation. Results After CRT there were significant increases in exercise cardiac output by 19.3% (P=0.0048) from 9.5±3.4 l min−1, peak mean arterial blood pressure by 14.1% (P=0.0001) from 91.3±13.6 mm Hg, and peak cardiac power output by 37.2% (P=0.0008) from 1.92±0.74 W. There were no significant changes in these variables at rest. Exercise duration (+42.3%, P=0.0002), NYHA functional class (P=0.0001) and SF-36 symptom score (P=0.0006) were also significantly improved. Powerful surrogate indicators of prognosis were also significantly improved with CRT: peak O2 consumption (+20.9%, P=0.0007), VE/VCO2 slope (−20.0%, P=0.005) and circulatory power (+42.0%, P=0.0012). Conclusion: In this cohort of patients, post-implant CRT significantly improved the flow-, pressure- and power-generating capacity of the failing hearts. This may be causally related to the improvements observed in exercise capacity, functional class and symptom scores.
Published: 2006

12. Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy

Author: Dominik Schlosshan, Lip-Bun Tan, and Diane Barker
Subjects: medicine.medical_specialty, Myocardial Infarction, Renin-Angiotensin System, chemistry.chemical_compound, Internal medicine, medicine, Humans, Myocardial infarction, Aldosterone, Thiazide, Mineralocorticoid Receptor Antagonists, Heart Failure, Ventricular Remodeling, Vascular disease, business.industry, Aldosterone Receptor Antagonist, medicine.disease, Eplerenone, chemistry, Heart failure, Cardiology, Myocardial fibrosis, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Half a century after the elucidation of its molecular structure, aldosterone is generating the greatest interest, not in the fields of endocrinology or renal medicine but in cardiology-where aldosterone over-activation is now perceived as detrimental in heart failure (HF) and ischaemic heart disease. Clinically, excess aldosterone is associated with higher morbidity and mortality after myocardial infarction (MI) and HF. The Randomised Aldactone Evaluation Study (RALES) study in severe chronic heart failure and the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival (EPHESUS) study in post-MI heart failure have shown that use of non-selective and selective aldosterone receptor antagonists, respectively, improves prognosis. The pathophysiological mechanisms underpinning these damaging aldosterone-mediated cardiovascular effects are still being elucidated, but prime candidates include cardiomyocyte necrosis and apoptosis, and myocardial fibrosis resulting in adverse cardiac remodelling, coronary vasculopathy, tachyarrhythmia and positive feedback activation of the renin-angiotensin-aldosterone system. Practical points for consideration when instigating therapy include preferential use of aldosterone receptor antagonists to maintain electrolyte balance whenever loop or thiazide diuretics are used (vulnerable HF patients require higher ranges of potassium and magnesium to minimise propensity for tachyarrthythmia), for renoprotection and for counteracting aldosterone breakthrough despite adequate ACE inhibition; use of the minimum doses of loop diuretics required to lessen activation of the renin-angiotensin-aldosterone system in HF; use of selective aldosterone receptor antagonists to avoid gynaecomastia/mastalgia and impotence; and prophylactic use of aldosterone receptor antagonists to improve prognosis.
Published: 2004

13. Pseudo SVT in the Pacemaker Patient

Author: Simon Modi, Mark Hall, Ash Patwala, Robert Cooper, and Diane Barker
Subjects: Tachycardia, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Sinus tachycardia, business.industry, General Medicine, medicine.disease, Internal medicine, cardiovascular system, medicine, Cardiology, cardiovascular diseases, Supraventricular tachycardia, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: This is an interesting report of a supraventricular tachycardia in a paced patient with intermittent atrioventricular nodal block. Only electrophysiology testing revealed the correct diagnosis. Images explain how pacemaker timing cycles and refractory periods can confuse an otherwise straightforward diagnosis.
Published: 2010

14. Thoracoscopic patch insulation to correct phrenic nerve stimulation secondary to cardiac resynchronization therapy

Author: Diane Barker, Peter Davies, Sandra Belchambers, Neeraj Mediratta, James McKevith, and Archana Rao
Subjects: Adult, medicine.medical_specialty, medicine.medical_treatment, Cardiac resynchronization therapy, Diaphragmatic breathing, Cardiac Resynchronization Therapy, Peripheral Nerve Injuries, Physiology (medical), Internal medicine, medicine, Thoracoscopy, Pericardium, Humans, General anaesthesia, Phrenic nerve, medicine.diagnostic_test, business.industry, musculoskeletal system, medicine.disease, Neuromuscular Blocking Agents, Electric Injuries, Phrenic Nerve, medicine.anatomical_structure, Treatment Outcome, Heart failure, Anesthesia, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Aims Cardiac resynchronization therapy is an established therapy for heart failure, improving quality of life and prognosis. Despite advances in technique, available leads and delivery systems, trans-venous left ventricular (LV) lead positioning remains dependent on the patient's underlying venous anatomy. The left phrenic nerve courses over the surface of the pericardium laterally and may be stimulated by the LV pacing lead, causing uncomfortable diaphragmatic twitch. This paper describes a video-assisted thoracoscopic (VATS) procedure to correct phrenic nerve stimulation secondary to cardiac resynchronization therapy. Methods and results Most current ways of avoiding phrenic stimulation involve either electronic reprogramming to distance the phrenic nerve from the stimulation circuit or repositioning the lead. We describe a case where the phrenic nerve was surgically insulated from the stimulating current by insinuating a patch of bovine pericardium between the epicardium and native pericardium of the heart thus completely resolving previously intolerable and incessant diaphragmatic twitch. The procedure was performed under general anaesthesia with single-lung ventilation and minimal use of neuromuscular blocking agents. Surgical patch insulation of the phrenic nerve was performed using minimally invasive VATS surgery, as a short-stay procedure, with no complications. No diaphragmatic twitch occurred post-surgery and the patient continued to gain symptomatic benefit from cardiac synchronization therapy (New York Heart Association Class III to II), enabling return to work. Conclusions In cases where the trans-venous position of a LV lead is limited by troublesome phrenic nerve stimulation, thoracoscopic surgical patch insulation of the phrenic nerve could be considered to allow beneficial cardiac resynchronization therapy.
Published: 2011

15. Recurrent ventricular tachycardia in the postoperative period: the danger of malfunctioning epicardial pacing wires

Author: Nathaniel Hawkins, Simon Modi, Diane Barker, and Mark Hall
Subjects: Pulmonary and Respiratory Medicine, Tachycardia, Male, medicine.medical_specialty, Pacemaker, Artificial, Time Factors, Epicardial pacing, Ischemia, Electrocardiography, Recurrence, Internal medicine, medicine, Humans, cardiovascular diseases, Coronary Artery Bypass, Aged, Heart Valve Prosthesis Implantation, medicine.diagnostic_test, Left ventricular impairment, business.industry, Recurrent ventricular tachycardia, Stunning, Cardiac Pacing, Artificial, Equipment Design, medicine.disease, Transvenous pacing, Treatment Outcome, Cardiology, cardiovascular system, Tachycardia, Ventricular, Surgery, Equipment Failure, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Ventricular arrhythmias in the postoperative period can be caused by a number of factors including ischaemia, left ventricular impairment or stunning, metabolic or mineral derangement, operative scar, and medication induced QT abnormalities. Of similar gravity, failure of postoperative epicardial pacing wires will generally leave patients either asystolic or markedly bradycardic, requiring either temporary transvenous pacing or permanent pacing. We report
Published: 2010

16. Cardiac functional reserve is diminished in growth hormone-deficient adults

Author: Lisa Sharp, Nigel Lewis, Lip-Bun Tan, David F. Goldspink, Robert Moisey, Steve Orme, Diane Barker, and Richard E. Clements
Subjects: Cardiac function curve, Adult, Male, medicine.medical_specialty, Hemodynamics, Blood Pressure, Hypopituitarism, Absorptiometry, Photon, Oxygen Consumption, Heart Rate, Internal medicine, Heart rate, medicine, Aerobic exercise, Body Size, Humans, Pharmacology (medical), Insulin-Like Growth Factor I, Pharmacology, Exercise Tolerance, business.industry, Human Growth Hormone, Cardiac reserve, Cardiorespiratory fitness, General Medicine, Middle Aged, Myocardial Contraction, Recombinant Proteins, medicine.anatomical_structure, Endocrinology, Blood pressure, Case-Control Studies, Vascular resistance, Cardiology, Exercise Test, Female, Vascular Resistance, Cardiology and Cardiovascular Medicine, business
Abstract: Various studies have shown that patients with severe growth hormone deficiency (GHD) have diverse changes in left ventricular (LV) size or performance but so far there is no direct indication of cardiac reserve ability to maintain the circulation during peak exercise. We tested the hypothesis that patients with severe GHD have reduced cardiac reserve function compared with healthy controls. Eighteen patients with severe GHD were studied and compared with 18 age-, sex-, and body mass index (BMI)-matched healthy controls. Peak cardiac power and cardiorespiratory fitness were investigated using noninvasive hemodynamic measurements during maximal cardiopulmonary exercise testing. Compared with matched controls, the cardiac power of GHD patients during exercise to volitional exhaustion was significantly reduced by 15% (mean +/- SD: 4.4 +/- 1.0 watts (W) vs. 5.2 +/- 1.0 W, P= 0.02), despite attaining similar aerobic exercise peaks (VO(2max), GHD: 2390 +/- 822 mL/min vs. controls: 2461 +/- 872 mL/min, P= 0.80) and similar peak respiratory exchange ratios. The lower peak cardiac power could not be accounted for by peripheral alterations because both groups reached similar peak exercise systemic vascular resistances. Patients with GHD also had lower cardiac chronotropic reserve (peak heart rate: 154 +/- 21 bpm vs. 174 +/- 11 bpm, P= 0.001) and a lower cardiac pressure-generating capacity (systolic blood pressure [SBP] 160 +/- 25 mmHg vs. 200 +/- 15 mmHg, P < 0.0001). Using this robust noninvasive method of assessing functional cardiac pumping capacity we have for the first time shown that patients with severe GHD have a significantly impaired cardiac functional reserve associated with chronotropic incompetence and impaired pressure-generating capacity.
Published: 2009

17. Exercise duration and peak systolic blood pressure are predictive of mortality in ambulatory patients with mild-moderate chronic heart failure

Author: Ashish Patwala, Leong L. Ng, Mark Jackson, Simon G. Williams, Lip-Bun Tan, and Diane Barker
Subjects: Adult, Male, medicine.medical_specialty, Systole, Blood Pressure, Severity of Illness Index, Ventricular Dysfunction, Left, Oxygen Consumption, Predictive Value of Tests, Internal medicine, Natriuretic Peptide, Brain, medicine, Humans, Pharmacology (medical), cardiovascular diseases, Exercise duration, Aged, Proportional Hazards Models, Ultrasonography, Heart Failure, business.industry, Stroke Volume, Middle Aged, medicine.disease, Survival Analysis, Blood pressure, Research Design, Heart failure, Ambulatory, Chronic Disease, Multivariate Analysis, cardiovascular system, Cardiology, Exercise Test, Physical Endurance, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Follow-Up Studies
Abstract: Background and Aims: It is a prevailing concept in chronic heart failure (CHF) that ventricular remodelling (evaluated via imaging) and neurohormonal activation (via biomarkers) exert major influences, such that the need to subject patients to haemodynamic evaluations and exercise testing has been questioned. We sought to investigate whether exercise and haemodynamic parameters lack independent prognostic value in a cohort of unselected ambulatory patients with mild-moderate CHF. Methods: Eighty-five consecutive patients with stable CHF in New York Heart Association functional classes I–IV, aged 55 ± 12 years, 84% males, left ventricular ejection fraction (LVEF) 37 ± 15%, participated in this study. Survivors were followed for a median of 5.08 years. All subjects underwent cardiopulmonary exercise testing to measure standard parameters including peak oxygen consumption, exercise duration and blood pressure. A sample of venous blood was taken to determine the N-terminal pro-brain natriuretic peptide (N-BNP) level. Echocardiography was performed at rest to measure LVEF. Predictors of mortality were sought using the Cox proportional hazards model. Results: All-cause mortality was 19% (16 deaths, 95% CI 11–29%). Age and LVEF did not independently predict mortality. Although various parameters including New York Heart Association class, peak oxygen consumption and N-BNP level were all predictive of outcome on univariate analysis, multivariate analysis identified reduced exercise duration and peak systolic blood pressure (SBP) to be the only independent predictors of all-cause mortality. Hazard ratios of 0.78 (95% CI 0.65–0.93, p = 0.007) and 0.79 (95% CI 0.66–0.95, p = 0.01) were associated with an increase in exercise duration of 1 min and 10 mm Hg peak SBP, respectively. Conclusions: Two simple parameters (exercise duration and peak SBP) that are easily measured by standard exercise testing are the strongest independent predictors of mortality which outperform LVEF and N-BNP in ambulatory patients with mild-moderate CHF.
Published: 2005

18. English translation of abstracts of original articles published in German 50 years ago on the discovery of aldosterone

Author: Dominik Schlosshan, Diane Barker, and Lip-Bun Tan
Subjects: medicine.medical_specialty, Aldosterone, Research groups, Stereochemistry, business.industry, Adrenal gland, Adrenal cortex, medicine.drug_class, Chemical structure, Publications, Paper chromatography, chemistry.chemical_compound, Endocrinology, medicine.anatomical_structure, chemistry, Mineralocorticoid, Internal medicine, medicine, Humans, Cardiology and Cardiovascular Medicine, business, Chemical decomposition, Language
Abstract: Chemical degradation of the new crystalline mineralocorticoid provisionally called electrocortin has shown that this compound is 11h,21-dihydroxy-3,20-diketo-4-pregnen18-al. In solution, this reacts mainly as the 11-hemiacetal. We suggest aldosterone as the definitive name for the compound. Simpson SA, Tait JF, Wettstein A, Neher R, von Euw J, Schindler O, Reichstein, T. Aldosteron, Isolierung und 0167-5273/$ see front matter D 2004 Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.ijcard.2004.05.005 * Corresponding author. Tel.: +44 113 392 5401; fax: +44 113 392 5395. Eigenschaften. Ueber Bestandteile der Nebennierenrinde und verwandte Stoffe. 91. Mitteilung. Helv. Chim. Acta 1954;37:1163–200. Title: Aldosterone. Isolation and characteristics. The constituents of the adrenal cortex and related substances. Abstract: We previously described, in two brief reports, the isolation and chemical structure of a new crystalline corticoid with a particularly potent effect on mineralocorticoid metabolism. The hormone was provisionally called electrocortin. After identification of its chemical structure the name aldosterone was suggested as the definitive name, which is in keeping with the internationally accepted nomenclature classification. In the mean time, the same substance has also been isolated in crystalline form by Mattox and co-workers. We report here the details of its chemical structure, isolation and its characteristics. We previously described, in two brief reports, the isolation and chemical structure of a new crystalline corticoid with a particularly potent effect on mineralocorticoid metabolism. The hormone was provisionally called electrocortin. After identification of its chemical structure the name aldosterone was suggested as the definitive name, which is in keeping with the internationally accepted nomenclature classification. In the mean time, the same substance has also been isolated in crystalline form by Mattox and co-workers. We report here the details of its chemical structure, isolation and its characteristics. Simpson SA, Tait JF, Wettstein A, Neher R, von Euw J, Schindler O, Reichstein, T. Die Konstitution des Aldosterons. Ueber Bestandteile der Nebennierenrinde und verwandte Stoffe. 92. Mitteilung. Helv. Chim. Acta 1954;37:1200–23. Title: The chemical structure of aldosterone. Constituents of the adrenal cortex and related substances. Abstract: We previously described, in two brief reports, the isolation and chemical structure of aldosterone. Details ology 96 (2004) 497–498 We previously described, in two brief reports, the isolation and chemical structure of aldosterone. Details ology 96 (2004) 497–498 D. Schlosshan et al. / International Journal of Cardiology 96 (2004) 497–498 498 regarding its isolation and the characteristics and derivatives of this hormone were described in the 91st report of this series. Here, we would like to report the results of the identification of its chemical structure. Chemical degradation of aldosterone has shown that this compound is an 18oxo-corticosterone. In solution, it probably can be found predominantly in the cyclohemiacetal form. Simpson SA, Tait JF, Wettstein A, Neher R, von Euw J, Reichstein, T. Isolierung eines neuen kristallisierten Hormons aus Nebennieren mit besonders hoher Wirksamkeit auf den Mineralstoffwechsel. Experientia 1953:9;333–5. Title: Isolation of a new crystalline hormone from the adrenal gland with a particularly potent effect on electrolyte metabolism. Recently, a new, highly sensitive method was described allowing rapid measurement of the effects of steroids on the ratio of urinary sodium and potassium output using only tracer amounts of substrate. With the help of this test, it was possible to demonstrate unequivocally that adrenal gland extracts indeed contain a specific substance with high activity that can also be detected after paper chromatographic separation and in the blood. It was also possible to purify this substance to a high degree. Using the method described above, the concentrates were 60–80 times more potent than cortexone. We have now been able to isolate this substance in a pure crystalline form from several concentrates prepared by our two research groups working in parallel in Basel. Methods and results: Extracts prepared from 500 kg of beef adrenals using the method described by Cartland and Kuizenga served as starting material. A total of 167 g of this material was purified using partition chromatography on large kiesleguhr columns with aqueous methanol:benzene solvent systems. Further purification using paper chromatography and repeated partition chromatography yielded 22 mg of the raw crystalline compound. Using the Na42/K42 method by Simpson and Tait, the compound described was around 100 times, and using the modified sodium retention method of Kagawa et al. around 50 times more potent than Cortexone. In (maintenance tests) in adrenalectomised dogs the compound appeared 30 times more potent than cortexone– acetate. Conclusion: We therefore consider that we have found a new important hormone of the adrenal cortex. We will report later about experiments leading to the chemical identification and synthesis of this compound as well as other more detailed biological experiments. We reserve the right to suggest a new name for the new compound at that time.
Published: 2004

19. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. Nguyen, J Farmer, M H Tan, Kwon H-S., J Yang, L Sandvik, Franco Folli, A K Jenum, M Nguyen, W Pratipanawatr, A L Frederiksen, Rebecca Smith, Lee H-J., A Schäfer, C Manuelli, G S Denver, T Vukovich, B Maceira, K Matsumoto, K. Chokkalingam, Nurcan Üçeyler, P Modi, Timothy M. Morgan, S Mertens, B M Singh, Michaela Riedl, K Iso, C Cucurullo, G. F. Bottazzo, M Calvani, K Hur, J Wetzels, Kazuhiro Takahashi, Y Aso, H Stammer, M G Masding, Fitsum Guebre-Egziabher, J L González-Sánchez, L Armstrong, Alberto Maran, Peter G.F. Swift, S S Popovic, J Starczynski, E Vitacolonna, Luigi Laviola, R W Gelling, Marina Cardellini, D Barilla, Rosa de Diego Martínez, W H Landschulz, Anne Mette Rosenfalck, R K Wong, Kevin E. Schneider, K Peros, Giuseppe Nanni, F Zhang, I Rákóczi, T Iburi, M Nakhjavani, X Q Zhang, S Tournis, Per Lav Madsen, Graham A. Hitman, A. Tura, K Laubner, N D Kostic, Lawrence M. Dolan, R. Sinha Roy, J A Wagner, J. Tuomilehto, J Hauptman, M Abdel-Ghany, D Lacombe, Toralph Ruge, Johannes A Maassen, Triantafyllos Didangelos, K Sasaki, I Argüelles, Klaus Levin, C Popow, Emanuel Christ, R Chetty, L Baillet-Blanco, Jo-Ann Salmon, T Mine, James L. Trevaskis, I Franke, J Gorski, E A Andrianova, A Dayan, A Caballero, Aleksandra Gilis-Januszewska, M Yasujima, Z Kasalová, C.D.A. Stehouwer, F. K. Gorus, G A Nichols, A Glowania, David P. Strachan, P Fredlund, N. F. da Silva, P Reboldi, M Sausbier, K H Groenier, G Stuccio, N Guttman, K R Ahmed, A D Ristic, T Kapellen, J Coutcher, Aldo V. Greco, Oswald Wagner, A Zagayko, Maria Alevizaki, B B Zhang, W F Ferris, Jenny Fredriksson, Lois Jovanovic, J Hänninen, R De Giglio, Kazuo Yagui, O Potterat, P Hamliton, R E Scranton, B Mankovsky, A Stylianou, B Fellström, Abdel-Wahab Yha., M Kitagawa, Katherine L. Baldock, F R Johnson, F Baigts, S D'Addato, F J Sanz, A Mistry, S D Wise, T Pratipanawatr, U R Fölsch, James R.C. Parkinson, Claudia Sommer, C Park, F E Griffiths, M L Martí, R Demirtunc, S Taniguchi, J Lundkvist, T Siegmund, Juan Sztajzel, C Dienesch, F Baumgartner, L Scalone, T M Mckolanis, K Otake, Ullrik Pedersen-Bjergaard, T M Vriesendorp, Michael B. Wheeler, Henry Schmitt, Peter Hovind, S Lange, Stephane Roze, L. Van Gaal, B Klaproth, Anthony E. Civitarese, D Eckland, A Dagar, D F Hopkins, Kari Stefansson, C Gonzalez-Yanes, B Meyboom-de Jong, D. J. Betteridge, K Buhling, M Crepaldi, Ana M. Wägner, L Renna, L Volpe, R McBride, V Corbo, E O Brennesvik, R P Hayes, R Abdollahnia, G Viviani, C F Liew, Francisco Pérez-Bravo, Jeffrey Baron, Brian M. Frier, H H Samira, D Szentendrei, K. J. Schjoedt, W K Waldhäusl, D Gniuli, D Zou, G Tschank, V Urbančič, A L Nolan, Albertini J-P., J Malcomson, M Larbig, C Cheyssac, K Aurich, C M Kesson, S Heller, Maija E. Miettinen, R F Luco, Adrian J. Cameron, Luigi Mattiello, Z. Metelko, X E Zhang, M Parramón, I. G. 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Thornalley, A Chaidaroglou, K Miura, B Zinman, O M Dvoynishnikova, J Plank, Jan Bolinder, C Lush, B Rubi, R Pozzilli, M Bashir, S A Shtandel, F Mosca, A Naskalska, Josef Vcelak, U Sausbier, P Cavaiani, T U Baehring, Michele Solimena, P Formisano, M Rastaldi, Bernard Thorens, J Ruzzin, E Arbit, M. Hori, Torkel B. Brismar, E Soltes Rak, A Filo, P Heinke, Matthew P. Coghlan, M Masotti, I Perevozskaya, K Ahn, I Moules, K Van Dyck, I Goldstein, Z Mathe, G Z Zhao, S Fajardo, J Taylor, S Chrul, J C Pareja, D Hadjidakis, A J Scheen, N Siddiqua, D C Cavan, R Grella, Krabbe S, H J Rochlitz, A E Hinkkanen, W Wilpshaar, Richard Stevens, M Dreyer, S Hara, X Wang, Melania Manco, D Gillen, Magalie A. Ravier, Olli Simell, John C. Lawrence, Kohnert K-D., Agardh C-D., A Berghold, L Kristensen, Grant Sfa., N Gursoy, Leif Groop, N Freemantle, Anja Schweizer, L Pala, Legros J-J., C. Di Pietro, N. Yamamoto, J Magyar, B Nikolovski, H Ikeda, D Lee, Bruce A. 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Leon, Alberti Gkm., A Opel, S Kokkoris, S B Hong, Philippe Courtois, L Haque, Maria Sörhede Winzell, M C Beauvois, A Szypowska, D Yu, M Gutniak, D Petzinna, B Isomaa, K S Prickett, Maria Felice Brizzi, Pavel Hamet, P J Hammond, K. F. Michelmore, Yumie Takeshita, N Hariharan, Corrado M. Cilio, G Pogatsa, W G Jerome, E Bartley, K Schlembacher, G Blohmó, Guy A. Rutter, Kyung Mook Choi, S. C Tamer, Felix K. Assah, K A Jandeleit-Dahm, M Chan, H Darius, Jørgen F. P. Wojtaszewski, A Papazisi, M Amaya, A Knopff, M Tadayyon, I J Kim, W Russ, T Myrnäs, M. Tryon, S Poonsatha, Noel Cameron, Kim M-H., Alejandra Tomas, F Homo-Dekarche, G. Di Cianni, M Stotzka, C Solimine, Mikhail Borisovich Antsiferov, H Naserke, M Bianchi-Biscay, J I Lara, Moon C-K., Alain Ktorza, Alison N. Jeffery, V Lilla, Eun Seok Kang, Hanley Ajg., J Widder, R Ratner, C Goretti, P J Weston, J Perkins, V Rasmussen, M Evans, T M Gibson, A Jaffe, S I Chisalita, C Owman, L Hiltunen, E Kakishita, C M Mack, H C Potter, M Femerling, M Desai, M Soinio, K Yang, Patricia L. Brubaker, M Meyer, V Dy, J Berden, R Komers, Milos Adamec, R Petzoldt, Alan G. Robinson, R Stevens, A Doi, A Leunda, Eduard Montanya, Alessandra K Cardozo, N Kraenkel, Claudio Cobelli, U A Mueller, S Yamashiro, B R Gedulin, G Francisco, J Dennenmoser, Lesch K-P., Martin G. Bischof, M Ichita, C Fernandes, Jochen Hampe, S Kern, D Kelly, E Zeender, P Perna, J D Best, A C Calkin, Vivian Fonseca, J Prestle, D G Parkes, Satish K. Garg, T Burrell, B M Fischer, D Kruger, J S Skinner, Lin T-M., Jozef Ukropec, Maria Jeziorska, K Arii, David D. D’Alessio, M B Gomes, L Quandt, I Fragaki, M C Brindisi, A Gladkih, E Kitsou, S Di Cola, T Iwasaki, Peter Diem, T Lakka, V V Popova, G Lee, Hannah J. 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Rodriguez rosas, H, Peiró martinez, I, Macías batista, A, Harte, A, Rodriguez cuenca, S, Valsamakis, G, Chetty, R, Anderson, L, Roca, P, Matyka, K, Lasalle, J, Hershon, K, Berman, L, Gibson, E, Gillen, D, Maroni, J, Simmons, D, Hiukka, A, Forder, P, Leinonen, E, Hilden, H, Fruchart, J, Keech, A, Farnier, M, Freeman, M, Macdonell, G, Perevozskaya, I, Mitchel, Y, Gumbiner, B, Didangelos, T, Athyros, V, Mikhailidis, D, Papageorgiou, A, Bouloukos, V, Pehlivanidis, A, Symeonidis, A, Elisaf, M, Mckenney, J, Insull, W, Lewin, A, Maccubbin, D, Kush, D, Schuster, H, Barter, P, Stender, S, Bonnet, J, Morrell, J, Watkins, C, Kallend, D, Stalenhoef, A, Ballantyne, C, Murin, J, Tonstad, S, Rose, H, Wilpshaar, W, Jenkins, A, Karschimkus, C, Dragicevic, G, Rowley, K, Wolthers, T, Best, J, Voet, B, Murdoch, S, Marcovina, S, Brunzell, J, Caparevic, Z, Kostic, N, Ilic, S, Sartore, G, Piarulli, F, Cantaro, S, Reitano, R, Fiore, C, Marin, R, Bassan, S, Manzato, E, Fedele, D, Solini, A, Santini, E, Thornalley, P, Babaei jadidi, R, Karachalias, N, Kupich, C, Ahmed, N, Fowler, A, Baker, A, Starczynski, J, O'Hare, P, Szepietowska, B, Szelachowska, M, Puch, U, Glebocka, A, Quinn, D, Mcternan, C, Bonser, R, Idzior walus, B, Woźniakiewicz, E, Dimitriou, K, Apostolou, O, Kontela, E, Devangelio, E, Gould, E, Serri, O, Roussin, A, Buithieu, J, Mamputu, J, Renier, G, Giordanetti, S, De Amici, E, Poggi, G, Turpini, C, Fratino, P, Garzaniti, A, Banu, I, Paries, J, Roman, G, Negrean, M, Bala, C, Nita, C, Kistorp, C, Gustafsson, F, Chong, A, Lip, G, Galatius, S, Ari, N, Sahilli, M, Ceylan isık, A, Ozansoy, G, Karasu yilmaz, C, Matteucci, E, Rosada, J, Pallini, M, Evangelista, I, Cassetti, G, Giusti, C, Giampietro, O, Capaldo, B, Galderisi, M, Cicala, S, Turco, A, Imbroinise, A, Nosso, G, D'Errico, A, De Divitiis, O, Klimontov, V, Korolyova, E, Jeltova, L, Bondar, I, Tarkun, I, Arslan, B, Canturk, Z, Tarkun, P, Agacdiken, A, Komsuoglu, B, Méneveau, N, Pierre justin, E, Alsayed, M, Sabbah, R, Paulin, S, Marcu, S, Tauveron, I, Zimmermann, C, Schiele, F, Seronde, M, Vautrin, P, Lusson, J, Thieblot, P, Bernard, Y, Mistry, A, Pye, M, Peovska, I, Maksimovic Pavlovic, J, Vavlukis, M, Pop Gorceva, D, Bosevski, M, Scognamiglio, R, Negut, C, De Kreutzenberg, S, Madonna, R, De Caterina, R, Willerson, J, Geng, Y, Vahsen, S, Ledwig, D, Ramrath, S, Frantz, S, Schmidt, I, Calvillo, L, Dienesch, C, Elbing, I, Bischoff, H, Ertl, G, Bauersachs, J, Davydov, A, Mkrtum'Yan, A, Baranova, L, Ikeda, Y, Suehiro, T, Osaki, F, Ota, K, Arii, K, Kumon, Y, Hashimoto, K, Doney, A, Morris, A, Palmer, C, Byun, S, Doo, H, Pagnin, E, Calo, L, Fadini, G, Kubaszek, A, Chai, S, Chai, Q, Rasmussen, L, Ledet, T, Wogensen, L, Lengyel, C, Varró, A, Virág, L, Magyar, J, Bíró, T, Jost, N, Skoumal, R, Nánási, P, Tóth, M, Horkay, F, Papp, J, Zacharopoulou, O, Athanaselis, S, Tsokos, N, Doupis, J, Psallas, M, Cokkinos, D, Pavlatos, S, Liatis, S, Akhobadze, T, Dzneladze, L, Samarguliani, I, Taskiran, M, Rasmussen, V, Jensen, G, Fisher, A, Petrovsky, N, Srikusalanukul, W, Budge, M, Trifunovic zamaklar, D, Zivkovic, M, Jelic, V, Vukomanovic, G, Ristic, A, Seferovic, P, Costa, J, Duarte, S, Manley, S, Sailesh, S, Venkataraman, A, Haider, Y, Groza, I, Oprean, M, Ardelean, A, Morosanu, A, Darkow, T, Vanderplas, A, Mamas, M, Mcelduff, P, Burns, J, Edwards, R, Fitchet, A, Young, R, Gibson, J, Lichiardopol, R, Niculescu, N, Totora, A, Pencea, C, Tomescu, I, Cinteza, M, Manicardi, V, Coscelli, C, Navazio, A, Catellani, E, Michelini, M, Dall'Asta, D, Guberti, A, Piazza, A, Gasparini, E, Pantaleoni, M, Guiducci, U, Manari, A, Sejil, S, Janand delenne, B, Avierinos, J, Habib, G, Labastie, N, Vague, P, Lassmann vague, V, Luźniak, P, Tatoń, J, Wojciechowska Luźniak, A, Zairis, M, Lyras, A, Patsourakos, N, Tsirimbis, V, Foussas, S, Lupón, J, Urrutia, A, Herreros, J, González, B, Coll, R, Altimir, S, Prats, M, Valle, V, Abreu padí, C, Rábago, G, Ivanova, L, Brasacchio, D, Harno, E, Keenan, A, Li, H, Lu, Z, Ke, L, Liu, H, Jeong, I, Chae, M, Choi, M, Yoo, H, Kim, C, Yun, M, Na, M, Kang, Y, Kong, O, Son, S, Kim, I, Tanaka, N, Hosoi, M, Matsuyama, Y, Fukumoto, M, Yamakita, T, Yoshioka, K, Ishii, T, Sato, T, Fujii, S, Aoki, T, Shibata, T, Mizutani, N, Suzuki, J, Fowelin, J, Samuelsson, P, Brandrup wogsen, G, Okumura, K, Tokmakova, A, Staroverova, D, Antcieferov, M, Shutichina, I, Kuntchevich, G, Vriesendorp, T, Morélis, Q, Legemate, D, Schaper, F, Mainas, E, Gkioulmpasanis, I, Panagiotou, I, Vassilikos, G, Skorda, L, Sidira, M, Christoforidou, M, Alaveras, A, Artikis, V, Evdemon, E, Lechleitner, M, Koch, T, Ebenbichler, C, Sturm, W, Moretti, L, Moruzzo, D, Boldrini, E, Pandolfo, C, Kameyama, M, Iwasa, R, Cho, M, Nam, J, Huh, K, Kaplar, M, Paragh, G, Erdei, A, Csongradi, E, Garai, I, Varga, J, Galuska, L, Udvardy, M, Higa, M, Kaneko, Y, Hiroi, N, Koziarska, D, Nowacki, P, Majkowska, L, Luzniak, P, Wojciechowska luźniak, A, Tushuizen, M, Nieuwland, R, Snoeck, D, Sturk, A, Diamant, M, Aguiar, L, Bahia, L, Villela, N, Laflor, C, Conde, C, Bottino, D, Dorigo, D, Bouskela, E, Pu, S, Luo, Z, Lam, K, Dan, Q, Xu, A, Shen, J, Cheng, K, Xu, J, Thamer, C, Stefan, N, Haap, M, Heller, E, Tschritter, O, De Prado, A, Ortiz, A, Ybarra, J, Gich, I, Pou, J, Ehren, M, Roggenland, D, Reinsen, B, Klein, H, Rittig, K, Stock, J, Kocher, B, Balletshofer, B, Shon, H, Chung, D, Nakatani, Y, Matsuhisa, M, Kaneto, H, Hatazaki, M, Yoshiuchi, K, Katakami, N, Kawamori, D, Ohtoshi, K, Sakamoto, K, Matsuoka, T, Ozawa, K, Ogawa, S, Hori, M, Yamasaki, Y, Zitouni, K, Harry, D, Nourooz zadeh, J, Earle, K, Olesen, P, Franco, L, Corvaja, C, Semplicini, A, Ceylan işık, A, Arı, N, Rösen, P, Lee, I, Park, K, Jung, E, Shin, D, Jo, S, Obuobie, K, Prakash, P, Hanna, F, Lazarus, J, Varadhan, L, Gurushankar, J, James, D, Sheikh, S, Gaede, P, Zou, D, Vilarrasa, N, Perez maraver, M, Mena, E, Perez, D, Setti, G, Buckingham, R, Urbančič, V, Stefanovska, A, Bernjak, A, Ažman juvan, K, Kocijančič, A, Glowania, A, Filters, T, Fosmark, D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

20. 352 The impact of cardiac resynchronisation therapy on systemic vascular resistance

Author: David F. Goldspink, Lip-Bun Tan, D.J. Wright, A.Y. Patwala, S.G. Williams, Paul Woods, and Diane Barker
Subjects: medicine.medical_specialty, medicine.anatomical_structure, business.industry, Internal medicine, Cardiology, medicine, Vascular resistance, Cardiology and Cardiovascular Medicine, business
Published: 2006

21. Comparison and Relation of Indirect and Direct Dynamic Indexes of Cardiac Pumping Capacity in Chronic Heart Failure

Author: Simon G. Williams, Diane Barker, Bing-H. Tzeng, and Lip-Bun Tan
Subjects: Male, Cardiac function curve, Mean arterial pressure, medicine.medical_specialty, Cardiac output, Heart disease, Cardiac index, Oxygen Consumption, Internal medicine, Humans, Medicine, Cardiac Output, Exercise, Heart Failure, business.industry, Middle Aged, medicine.disease, Heart failure, Chronic Disease, Circulatory system, Ambulatory, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Cardiac power output (CPO), the product of cardiac output (CO) and mean arterial pressure (MAP), is a direct measure of cardiac pumping capability and is strongly indicative of prognosis and exercise ability in patients with chronic heart failure (CHF). However, it is not as easily measured as indirect indicators of cardiac function, such as peak oxygen consumption (VO(2)) or peak "circulatory power" (CircP), the product of VO(2) and MAP. The relation between direct and indirect indexes of cardiac pumping capacity was evaluated in 219 ambulatory patients with CHF. CircP was found to have a direct and consistent relation with CPO, overall (R = 0.93, p
Published: 2005

22. 209 Cardiac resynchronisation therapy improves cardiac and physical functional reserve in patients with chronic heart failure

Author: Chris Pepper, Lip-Bun Tan, Diane Barker, A. Farrell, G. Wharton, Dominik Schlosshan, and Gordon H. Williams
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Heart failure, Cardiology, medicine, In patient, Cardiology and Cardiovascular Medicine, business, medicine.disease
Published: 2004

23. Obese Patients with Equivalent NYHA Have Less Cardiac Impairment Than Non-Obese Counterparts

Author: L B Tan, Nigel Lewis, Shanmugakumar Chinnappa, David F. Goldspink, and Diane Barker
Subjects: medicine.medical_specialty, Non obese, business.industry, Internal medicine, Cardiology, medicine, Cardiology and Cardiovascular Medicine, business
Published: 2011

24. Pacemaker lead overcoiling: the overcoil-retraction phenomenon

Author: Simon Modi, Diane Barker, and Archana Rao
Subjects: medicine.medical_specialty, business.industry, Middle Cardiac Vein, Equipment Design, Surgery, Cardiac Resynchronization Therapy, Radiography, Foreign-Body Migration, Internal medicine, Biventricular defibrillator, cardiovascular system, Cardiology, Humans, Medicine, Equipment Failure, Cardiac Resynchronization Therapy Devices, Cardiology and Cardiovascular Medicine, business, Innominate vein, Lead (electronics)
Abstract: The image (figure 1) shows the dangers of lead overcoiling. In the first post-implant image, a biventricular defibrillator is present with a St. Jude Quicksite left ventricular (LV) lead (SJM, Saint Paul, Minnesota, USA) positioned in a middle cardiac vein. On day 1 post-implant, loss of LV capture was noted. Repeat x-ray shows that the LV lead recoiled to the innominate vein (solid black …
Published: 2011

25. 065 VO2max/kg is unreliable as an indicator of cardiac function in obese patients

Author: Mary O'Kane, L B Tan, Diane Barker, Stephen Pollard, Lisa Sharp, Nigel Lewis, and Richard Clement
Subjects: Cardiac function curve, medicine.medical_specialty, business.industry, medicine.medical_treatment, Rebreathing method, Cardiac reserve, Treadmill exercise, Body weight, Surgery, Transplantation, Internal medicine, Heart–lung transplant, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, human activities, Female population
Abstract: Background Oxygen consumption has been conventionally normalised for different body sizes by dividing it with body weight. For instance, peak O2 consumption (VO2max) of ≤14 ml/kg/min has been widely accepted as being indicative of poor cardiac function warranting consideration for transplantation ( J Heart Lung Transplant 2006; 25 :1024). However, how well division of VO2max by body weight adjusts for size in obese patients is unclear. Methods Employing the normal ranges of VO2max of a representative British female population (n=140, age 47.5±1.2(SEM) years, BMI 25.45±0.33) as controls, we studied morbidly obese British female subjects and measured their physical and cardiac functional reserve during weight-bearing treadmill exercise testing with respiratory gas analyses and rebreathing method of non-invasively measuring cardiac outputs during peak exercise. Results Morbidly obese women were screened and 20 (age 44.4±11.9 (SD) years, BMI 51.9±9.4) managed to exercise to acceptable cardiopulmonary limits (peak RER=1.03±0.11), and achieved VO2max of 14.4±2.2 mls/kg/min which was significantly lower than controls (27.5±5.9 mls/kg/min, p 0.1). The peak cardiac power output (CPOmax, 5.0±1.0 W) was clearly not below normal (4.2±0.7 W, [Abstract 65 Figure 2][2]). Of the eight patients with VO2max/kg below the transplant cutoff, all had above average normal CPOmax. ![Abstract 65 Figure 1][3] Abstract 65 Figure 1 ![Abstract 65 Figure 2][3] Abstract 65 Figure 2 Conclusion The conventionally measured VO2max/kg suggests that obese patients have very poor cardiac function, but this contradicted with evidence from directly measured cardiac reserve. The use of VO2max corrected with body weight for transplant assessment can be misleading and needs reappraisal. [1]: #F1 [2]: #F2 [3]: pending:yes
Published: 2010

26. 066 Vasodilatory capacity at peak exercise in treated heart failure patients are not diminished

Author: L B Tan, Nigel Lewis, Ashish Y. Patwala, Dominik Schlosshan, Diane Barker, and David F. Goldspink
Subjects: medicine.medical_specialty, business.industry, Hemodynamics, Vasodilation, Exercise capacity, medicine.disease, Peripheral, Surgery, Heart failure, Internal medicine, medicine, Cardiology, Respiratory system, Maximal exercise, Cardiology and Cardiovascular Medicine, business, Peak exercise
Abstract: Background Previous received dogma has propagated the concept that heart failure (HF) patients have compromised vasodilatory capacity during exercise through various vascular mechanisms, thereby reducing their exercise capacity through peripheral (vascular) factors rather than central (cardiac) factors. We tested whether such a concept is still valid in modern HF patients receiving current standard HF therapies. Methods and Results We recruited 150 female participants (133 normal healthy controls, age 48.5±13.1 (SD) years; 17 DCM patients, age 41.5±14.2 years) with no known coronary or other vascular diseases, and compared their central haemodynamic responses during volitional maximal exercise. The exercise capacity of controls spanned the same ranges as those of the HF patients. All patients performed symptom-limited cardiopulmonary exercise testing (CPX) with breath-by-breath analyses of respiratory gases and non-invasive haemodynamic measurements employing standard auscultatory sphygmomanometric and rebreathing methods. The patients performed a total of 30 CPX9s. The peak O2 consumption spanned from 1.20 to 2.45 L/min in DCM patients and from 1.15 to 2.44 L/min in controls. As shown in the figure, at peak exercise the systemic vascular resistances (SVR) of DCM patients were lower (532±154 dyn.s.cm-5) than those of controls (654±118 dyn.s.cm-5). Conclusion With modern HF therapy, the lower peak exercise SVR in HF patients compared to normal healthy controls demonstrates that there is no evidence of compromised systemic vasodilatory capacities in HF patients. The long-held dogma of vasodilatory incapacity in HF propagated >3 decades ago is no longer valid nowadays.
Published: 2010

27. Cardio-respiratory Fitness Affects Glucose Control And Thus Cardiovascular Disease Risk In Postmenopausal Women

Author: Nigel Lewis, Diane Barker, Lip-Bun Tan, Karen M. Birch, and Sally E. Barber
Subjects: medicine.medical_specialty, Postmenopausal women, Glucose control, business.industry, Internal medicine, Disease risk, Medicine, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Cardiorespiratory fitness, business
Published: 2009

28. VO2 peak Relates to Endothelial Function Independently of Other Cardiovascular Disease Risk Factors in Postmenopausal Women

Author: Lip-Bun Tan, Diane Barker, Karen M. Birch, and Sally E. Barber
Subjects: Oncology, medicine.medical_specialty, Postmenopausal women, business.industry, Internal medicine, Disease risk, Medicine, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, business
Published: 2007

29. Assessment of maternal heart disease: Discrepancy between direct and indirectly measured cardiac function during pregnancy

Author: Diane Barker, Dominik Schlosshan, Lip-Bun Tan, Gerald Mason, and Hilary Mcloughlin
Subjects: Cardiac function curve, medicine.medical_specialty, Pregnancy, Heart disease, business.industry, Internal medicine, Cardiology, Obstetrics and Gynecology, Medicine, business, medicine.disease
Published: 2005

30. Plasma brain natriuretic peptide may not be useful to assess possible cardiac symptoms during pregnancy

Author: Dominik Schlosshan, Lip-Bun Tan, Simon G. Williams, Diane Barker, Gerald Mason, and Hilary Mcloughlin
Subjects: medicine.medical_specialty, Pregnancy, business.industry, Internal medicine, Cardiology, Obstetrics and Gynecology, Medicine, business, Brain natriuretic peptide, medicine.disease, Cardiac symptoms
Published: 2005

31. A novel approach to maternal cardiac disease - A generic test to evaluate the functional adequacy of individual diseased hearts to cope with pregnancy and labor

Author: Diane Barker, Dominik Schlosshan, Lip-Bun Tan, Hilary Mcloughlin, and Gerald Mason
Subjects: medicine.medical_specialty, Pregnancy, business.industry, Internal medicine, Cardiology, Obstetrics and Gynecology, Medicine, Disease, business, Intensive care medicine, medicine.disease, Test (assessment)
Published: 2005

32. Impaired left ventricular function in obesity?

Author: Hilary Mcloughlin, Lip-Bun Tan, Diane Barker, and Simon G. Williams
Subjects: medicine.medical_specialty, Text mining, business.industry, Internal medicine, Cardiology, Medicine, Impaired left ventricular function, Cardiology and Cardiovascular Medicine, business, medicine.disease, Obesity
Published: 2005

33. Cyclic AMP-Dependent Melatonin Production in Y79 Human Retinoblastoma Cells

Author: Mary E. Pierce, Julie Harrington, Joseph S. Takahashi, and Diane Barker
Subjects: endocrine system, medicine.medical_specialty, Trilateral retinoblastoma, 8-Bromo Cyclic Adenosine Monophosphate, Biology, Biochemistry, 5-Hydroxytryptophan, Melatonin, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 1-Methyl-3-isobutylxanthine, Internal medicine, Cyclic AMP, Tumor Cells, Cultured, medicine, Humans, Phosphodiesterase inhibitor, Retina, Forskolin, Retinoblastoma, Colforsin, Middle Aged, medicine.disease, eye diseases, Endocrinology, medicine.anatomical_structure, chemistry, Cell culture, hormones, hormone substitutes, and hormone antagonists, Hormone, medicine.drug
Abstract: Melatonin is rhythmically synthesized in some vertebrate retinas and has been implicated in the regulation of key rhythmic events in the photoreceptor-pigment epithelial complex. In human retina, melatonin is present; however, no information exists on the cellular regulation of this hormone. We report here that the established human retinoblastoma cell line Y79 synthesizes and releases melatonin. Treatments that elevate cyclic AMP (cAMP) levels (forskolin, 8-Br-cAMP, and the phosphodiesterase inhibitor 3-isobutyl-1 -meth-ylxanthine) all stimulate melatonin release from static cultures of Y79 cells. Other 8-bromo nucleotide analogues (cyclic GMP, ATP, and AMP) are not effective. These results suggest that Y79 human retinoblastoma cells require a cAMP-dependent mechanism for melatonin biosynthesis similar to that described previously in other vertebrates. This is the first demonstration of melatonin release from a cultured human cell line. These results support the idea that human retinal cells share homologies with pineal cells, as suggested by the condition trilateral retinoblastoma.
Published: 1989

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33 results on '"Diane Barker"'

1. Outcomes of Patients Who Have Incidental Non-Sustained Ventricular Tachycardia Identified on Cardiac Implantable Electronic Device Interrogation

2. Prevalence, Outcomes, and Costs According to Patient Frailty Status for 2.9 Million Cardiac Electronic Device Implantations in the United States

3. The role of the Tei index in assessing for cardiotoxicity from anthracycline chemotherapy: a systematic review

4. Sex Disparities in the Choice of Cardiac Resynchronization Therapy Device: An Analysis of Trends, Predictors, and Outcomes

5. Trends of Sex Differences in Outcomes of Cardiac Electronic Device Implantations in the United States

6. Early Readmissions After Acute Myocardial Infarction

7. Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review

8. Reduced cardiac functional reserve and quality of life in adults with GH deficiency

9. A Mechanistic Investigation Into How Long-Term Resynchronization Therapy Confers Ongoing Cardiac Functional Benefits and Improved Exercise Capacity

10. Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis

11. CRT improves the exercise capacity and functional reserve of the failing heart through enhancing the cardiac flow- and pressure-generating capacity

12. Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy

13. Pseudo SVT in the Pacemaker Patient

14. Thoracoscopic patch insulation to correct phrenic nerve stimulation secondary to cardiac resynchronization therapy

15. Recurrent ventricular tachycardia in the postoperative period: the danger of malfunctioning epicardial pacing wires

16. Cardiac functional reserve is diminished in growth hormone-deficient adults

17. Exercise duration and peak systolic blood pressure are predictive of mortality in ambulatory patients with mild-moderate chronic heart failure

18. English translation of abstracts of original articles published in German 50 years ago on the discovery of aldosterone

19. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

20. 352 The impact of cardiac resynchronisation therapy on systemic vascular resistance

21. Comparison and Relation of Indirect and Direct Dynamic Indexes of Cardiac Pumping Capacity in Chronic Heart Failure

22. 209 Cardiac resynchronisation therapy improves cardiac and physical functional reserve in patients with chronic heart failure

23. Obese Patients with Equivalent NYHA Have Less Cardiac Impairment Than Non-Obese Counterparts

24. Pacemaker lead overcoiling: the overcoil-retraction phenomenon

25. 065 VO2max/kg is unreliable as an indicator of cardiac function in obese patients

26. 066 Vasodilatory capacity at peak exercise in treated heart failure patients are not diminished

27. Cardio-respiratory Fitness Affects Glucose Control And Thus Cardiovascular Disease Risk In Postmenopausal Women

28. VO2 peak Relates to Endothelial Function Independently of Other Cardiovascular Disease Risk Factors in Postmenopausal Women

29. Assessment of maternal heart disease: Discrepancy between direct and indirectly measured cardiac function during pregnancy

30. Plasma brain natriuretic peptide may not be useful to assess possible cardiac symptoms during pregnancy

31. A novel approach to maternal cardiac disease - A generic test to evaluate the functional adequacy of individual diseased hearts to cope with pregnancy and labor

32. Impaired left ventricular function in obesity?

33. Cyclic AMP-Dependent Melatonin Production in Y79 Human Retinoblastoma Cells

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33 results on '"Diane Barker"'

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