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1. SYNTAX Score and Long-Term Outcomes

Author

Fumiaki Ikeno, Maria Mori Brooks, Kaori Nakagawa, Min-Kyu Kim, Hideaki Kaneda, Yoshiaki Mitsutake, Helen A. Vlachos, Leonard Schwartz, Robert L. Frye, Sheryl F. Kelsey, Katsuhisa Waseda, Mark A. Hlatky, Katherine M. Detre, Trevor J. Orchard, Stephen B. Thomas, Kim Sutton Tyrrell, Jamal S. Rana, Frani Averbach, Joan M. MacGregor, Scott M. O’Neal, Kathleen Pitluga, Veronica Sansing, Mary Tranchine, Sharon W. Crow, Marianne (Marnie) Bertolet, Regina Hardison, Kevin Kip, Manuel Lombardero, Jiang Lu, Sue Janiszewski, Darina Protivnak, Sarah Reiser, Stephen Barton, Ping Guo, Yulia Kushner, Owen Michael, Jeffrey P. Martin, Christopher Kania, Michael Kania, Jeffrey O’Donnell, Rae Ann Maxwell, Suzanne Goldberg, Yves Rosenberg, Patrice Desvigne-Nickens, Abby Ershow, David Gordon, Dina Paltoo, Teresa L.Z. Jones, Whady Hueb, José Ramires, Neuza Lopes, Bernardo Léo Wajchenberg, Eulogio E. Martinez, Sergio A. Oliveira, Expedito E. Ribeiro, Marcos Perin, Roberto Betti, George Steiner, Alan Barolet, Yolanda Groenewoud, Lisa Mighton, Kathy Camelon, Robert O’Rourke, Janet Blodgett, Edward Sako, Judith Nicastro, Robin Prescott, Charanjit Rihal, Frank Kennedy, Gregory Barsness, Amanda Basu, Alfredo Clavell, Robert Frye, David R. Holmes, Amir Lerman, Charles Mullaney, Guy Reeder, Robert Rizza, Hartzell Schaff, Steven Smith, Virend Somers, Thoralf Sundt, Henry Ting, R. Scott Wright, Pam Helgemoe, Diane Lesmeister, Deborah Rolbiecki, Luis Lepe-Montoya, Jorge Escobedo, Rafael Barraza, Rubén Baleón, Arturo Campos, Paula García, Carlos Lezama, Carlos Miramontes, Salvador Ocampo, Joaquín V. Peñafiel, Aquiles Valdespino, Raúl Verdín, Héctor Albarrán, Fernando Ayala, Eduardo Chávez, Héctor Murillo, Luisa Virginia Buitrón, Beatriz Rico-Verdin, Fabiola Angulo, Dale Adler, Austin Arthur Halle, Faramarz Ismail-Beigi, Suvinay Paranjape, Stacey Mazzurco, Karen Ridley, Kodangudi Ramanathan, Solomon Solomon, Barry Wall, Darryl Weinman, Tammy Touchstone, Lillie Douglas, Martial Bourassa, Jean-Claude Tardif, Jean-Louis Chiasson, Marc Andre Lavoie, Rémi Rabasa-Lhoret, Hélène Langelier, Suzy Foucher, Johanne Trudel, Scott Monrad, Vankeepuram Srinivas, Joel Zonszein, Jill Crandall, Helena Duffy, Eugen Vartolomei, Spencer King, Carl Jacobs, David Robertson, Marty Porter, Melanie Eley, Emmalee Nichols, Jennifer LaCorte, Melinda Mock, William Rogers, Fernando Ovalle, David Bell, Vijay K. Misra, William B. Hillegass, Raed Aqel, Penny Pierce, Melanie Smith, Leah Saag, Ashley Vaughn, Dwight Smith, Tiffany Grimes, Susan Rolli, Roberta Hill, Beth Dean Barrett, Clarinda Morehead, Ken Doss, Charles J. Davidson, Mark Molitch, Nirat Beohar, Elaine Massaro, Lynne Goodreau, Fabiola Arroyo, Petr Neužil, Lenka Pavlickova, Štĕpánka Stehlíková, Jaroslav Benedik, Liz Coling, Richard Davies, Christopher Glover, Michel LeMay, Thierry Mesana, Teik Chye Ooi, Mark Silverman, Alexander Sorisky, Colette Favreau, Susan McClinton, Melvin Weiss, Irene Weiss, Leo Saulle, Harichandra Kannam, Joanne C. Kurylas, Lorraine Vasi, John Douglas, Ziyad Ghazzal, Laurence Sperling, Priya Dayamani, Suzanne Gebhart, Sabreena Basu, Tarek Helmy, Vin Tangpricha, Pamela Hyde, Margaret Jenkins, Barbara P. Grant, Kenneth Kent, William Suddath, Michelle Magee, Patricia Julien-Williams, Vida Reed, Carine Nassar, Gilles Dagenais, Claude Garceau, Dominique Auger, Christopher Buller, Tom Elliott, Krishnan Ramanathan, Donald Ricci, Rebecca Fox, Daniela Kolesniak, Michael Attubato, Frederick Feit, Stephen Richardson, Ivan Pena Sing, James Slater, Angela Amendola, Bernardo Vargas, Nicholas Tsapatsaris, Bartholomew Woods, Gary Cushing, Martin Rutter, Premranjan Singh, Gail DesRochers, Gail Woodhead, Deborah Gannon, Nancy Shinopulos Campbell, Michael Ragosta, Ian Sarembock, Eric Powers, Eugene Barrett, Linda Jahn, Karen Murie, Gladwin Das, Gardar Sigurdsson, Carl White, John Bantle, J. Bruce Redmon, Christine Kwong, Jacqueline Tamis-Holland, Jeanine Albu, Judith S. Hochman, James Wilentz, Sylvaine Frances, Deborah Tormey, Carl Pepine, Karen Smith, Laurence Kennedy, Karen Brezner, Tempa Curry, Frank Bleyer, Stewart Albert, Arshag Mooradian, Sharon Plummer, Francisco Fuentes, Roberto Robles, Victor Lavis, Jaime Gomez, Cesar Iliescu, Carol Underwood, Maria Selin Fulton, Julie Gomez Ramirez, Jennifer Merta, Glenna Scott, Ashok Krishnaswami, Lynn Dowdell, Sarah Berkheimer, Adam Greenbaum, Fred Whitehouse, Raquel Pangilinan, Kelly Mann, Alice K. Jacobs, Elliot Sternthal, Susana Ebner, Zoran Nedeljkovic, Paula Beardsley, David Schneider, Richard Pratley, William Cefalu, Joel Schnure, Michaelanne Rowen, Linda Tilton, Alan Niederman, Cristina Mata, Terri Kellerman, John Farmer, Alan J. Garber, Neal Kleiman, Nancy Howard, Debra Nichols, Madonna Pool, Christopher Granger, Mark Feinglos, George Adams, Jennifer Green, Bernadette Druken, Dani Underwood, J. Lawrence Stafford, Thomas Donner, Warren Laskey, Dana Beach, John Lopez, Andrew Davis, David Faxon, Sirimon Reutrakul, Emily Bayer, Oscar Marroquin, Howard Cohen, Mary Korytkowski, Glory Koerbel, Lisa Baxendell, Debbie Rosenfelder, Louise DeRiso, Carole Farrell, Tina Vita, Janet McGill, Ronald Krone, Richard Bach, Carol Recklein, Kristin M. Luepke, Mary Jane Clifton, Michael E. Farkouh, Michael C. Kim, Donald A. Smith, Ida Guzman, Arlene Travis, James O’Keefe, Alan Forker, William Isley, Richard Moe, Paul Kennedy, Margaret Rosson, Aimee Long, Eric Bates, William Herman, Rodica Pop-Busui, Claire Duvernoy, Martin Stevens, Ann Luciano, Cheryl Majors, Sheldon H. Gottlieb, Annabelle Rodriguez, Melanie Herr, David Williams, Robert J. Smith, J. Dawn Abbott, Marc J. Laufgraben, Mary Grogan, Janice Muratori, Gabriel Habib, Marco Marcelli, Issam Mikati, Emilia Cordero, Gina Caldwell, David Schechter, Daniel Lorber, Phyllis August, Maisie Brown, Patricia Depree, Kurt Huber, Ursula Hanusch-Enserer, Nelly Jordanova, Dilek Cilesiz, Birgit Vogel, Ben McCallister, Michael Kleerekoper, Kelly Mandagere, Robert Urbanic, James Bengston, Bobby K. Kong, Andrew Pruitt, Jeffrey Sanfield, Carol Carulli, Ruth Churley-Strom, Raymond Magorien, Kwame Osei, Cecilia Casey Boyer, Richard Lee, Pasquale Palumbo, Joyce Wisbey, Edwin Alderman, Anne Schwarzkopf Michael Steffes, Maren Nowicki, Jean Bucksa, Bernard Chaitman, Jane Eckstein, Karen Stocke, Derek B. Boothroyd, Kathryn A. Melsop, Burton E. Sobel, Dagnija Neimane, Ami E. Iskandrian, Mary Beth Schaaf, Saul Genuth, Theresa Bongarno, Richard Nesto, Karen Hultberg, Helene Rosenhouse-Romeo, Georgia Pambianco, Michael Mock, Sheryl Kelsey, Trevor Orchard, Thomas Ryan, Harold Lebovitz, Robert Brown, Gottlieb Friesinger, Edward Horton, Jay Mason, Renu Virmani, Lawrence Wechsler, C. Noel Bairey-Merz, J. Ward Kennedy, Elliott Antman, John Colwell, Sarah Fowler, Curt Furberg, Lee Goldman, Bruce Jennings, and Scott Rankin

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Hazard ratio, Percutaneous coronary intervention, 030204 cardiovascular system & hematology, medicine.disease, Revascularization, humanities, Cardiac surgery, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Angioplasty, Conventional PCI, medicine, Cardiology, 030212 general & internal medicine, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, Stroke
Abstract

Background The extent of coronary disease affects clinical outcomes and may predict the effectiveness of coronary revascularization with either coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). The SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score quantifies the extent of coronary disease. Objectives This study sought to determine whether SYNTAX scores predicted outcomes and the effectiveness of coronary revascularization compared with medical therapy in the BARI-2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Methods Baseline SYNTAX scores were retrospectively calculated for BARI-2D patients without prior revascularization (N = 1,550) by angiographic laboratory investigators masked to patient characteristics and outcomes. The primary outcome was major cardiovascular events (a composite of death, myocardial infarction, and stroke) over 5 years. Results A mid/high SYNTAX score (≥23) was associated with a higher risk of major cardiovascular events (hazard ratio: 1.36, confidence interval: 1.07 to 1.75, p = 0.01). Patients in the CABG stratum had significantly higher SYNTAX scores: 36% had mid/high SYNTAX scores compared with 13% in the PCI stratum (p Conclusions Among patients with diabetes and stable ischemic heart disease, higher SYNTAX scores predict higher rates of major cardiovascular events and were associated with more favorable outcomes of revascularization compared with medical therapy among patients suitable for CABG. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes; NCT00006305)

Published
2017
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2. EFFECTS OF HYPERVENTILATION ON ECG IN PATIENTS WITH CIRCULATORY DISTURBANCES

Author

Curt Furberg and Håkan Linderholm

Subjects
Adult, Male, Cardiac Catheterization, Cardiac Volume, Posture, Blood Pressure, Angina Pectoris, Electrocardiography, Hemoglobins, Heart Rate, Hyperventilation, Internal Medicine, Humans, Medicine, In patient, Blood Volume, business.industry, Body Weight, Middle Aged, Hypoxia (medical), Body Height, Orthostatic test, Cardiovascular Diseases, Asthenia, Anesthesia, Blood Circulation, Hypertension, Circulatory system, Exercise Test, Female, medicine.symptom, business
Abstract

The ECG has been recorded in patients with vasoregulatory asthenia, coronary insufficiency and arterial hypertension, as well as in healthy controls at rest, after hyperventilation, during an orthostatic test and a work test. S-T and T depressions, usually of sympathicotonic type, appeared or were accentuated after hyperventilation, particularly in patients with vasoregulatory asthenia, who also showed similar changes during an orthostatic test. Such ECG changes were uncommon in the other groups. The results sustain the concept that an increased sympathetic autonomic nervous tone provoked by hyperventilation causes the S-T and T depressions, particularly in patients with vasoregulatory asthenia. The diagnostic value of the hyperventilation ECG for analysing functional S-T and T depressions is emphasized, as well as the diagnostic difficulties in the evaluation of ECG changes in patients who hyperventilate, for instance during a hypoxia test.

Published
2009
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3. EFFECTS OF REPEATED WORK TESTS AND ADRENERGIC BETA-BLOCKADE ON ELECTROCARDIOGRAPHIC ST AND T CHANGES

Author

Curt Furberg

Subjects
Adult, Male, Time Factors, Myocarditis, Adolescent, Heart Diseases, Posture, Adrenergic, Electrocardiography, Methods, Internal Medicine, Humans, Medicine, In patient, Beta (finance), Organic heart disease, business.industry, Adrenergic blockade, Heart, Middle Aged, medicine.disease, Propranolol, Blockade, Anesthesia, Exercise Test, Sympatholytics, Female, sense organs, business, Mathematics
Abstract

The effect of a number of repeated work tests on different electrocardiographic ST and T changes has been studied and the effect compared with that after an adrenergic beta-receptor blockade. In subjects with different ECG changes but without any apparent organic heart disease there was a normalization of the ST and T changes during the period of repeated work tests. The normalizing effect was almost identical to that after adrenergic blockade. Different patterns of ST and especially T depressions on the ECG at rest, in the standing position and during and after work are described. In patients with organic heart diseases the repeated work tests generally had no effect on the ECG patterns typical of coronary insufficiency and myocarditis. In one patient with signs of a vasoregulatory disturbance there seemed to be ST and T changes of different origin, probably both functional and organic. The effect of the adrenergic blockade was almost identical to that of the repeated work tests. The study gives support to the results of a previous investigation in which the possibility of using an adrenergic blockade for differentiating between ECG changes of functional and organic origin was pointed out. The normalization effect of 4–6 work tests over a period of 4–6 days on functional ST and T changes on the ECG is supposed to be due to a physical and psychic adaptation to the work tests and to the examination situation.

Published
2009
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4. Propranolol and Angina Pectoris

Author

Curt Furberg and K. A. Jacobsson

Subjects
Drug, medicine.medical_specialty, business.industry, media_common.quotation_subject, Propranolol, medicine.disease, Angina, Internal medicine, Internal Medicine, medicine, Cardiology, In patient, business, media_common, medicine.drug
Published
2009
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5. TOWARD IDENTIFYING PERSONALIZED PROGNOSIS IN HYPERTENSION: VARIATION IN EARLY RESPONSES IN THE ANTIHYPERTENSIVE AND LIPID-LOWERING TREATMENT TO PREVENT HEART ATTACK TRIAL (ALLHAT)

Author

Frederick Warner, Harlan M. Krumholz, Sanket S. Dhruva, Chenxi Huang, Barry Davis, Shu-Xia Li, Curt Furberg, Erica S. Spatz, Sara Pressel, Andreas Coppi, Haiqun Lin, Xiao Xu, and Ronald R. Coifman

Subjects
medicine.medical_specialty, Randomized controlled trial, business.industry, law, Internal medicine, Physical therapy, medicine, Mixture modeling, Lipid lowering, Cardiology and Cardiovascular Medicine, business, law.invention
Abstract

Background: Prior randomized trials of hypertension have rarely examined patient heterogeneity in response to treatments and the implications for outcomes. Methods: We applied growth mixture modeling to identify distinct SBP trajectory classes within the first 6 months of ALLHAT. We assessed the

Published
2017
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6. FAMILIAL QT PROLONGATION and RISK OF SUDDEN DEATH

Author

Curt Furberg and Herje HöRNELL

Subjects
Heart Defects, Congenital, medicine.medical_specialty, Adolescent, Familial disorder, Deafness, QT interval, Sudden death, Syncope, Death, Sudden, Electrocardiography, Internal medicine, medicine, Humans, Child, biology, business.industry, Syncope (genus), Syndrome, General Medicine, medicine.disease, biology.organism_classification, Clinical Physiology, Pediatrics, Perinatology and Child Health, Cardiology, Female, Medical emergency, business
Abstract

Furberg, C. and Hornell, H. (Department of Clinical Physiology and Paediatrics, Central Hospital, Boden, Sweden). Familial QT prolongation and risk of sudden death. Acta Paediatr Scand, 64:777, 1975.–Two sisters with the syndrome of familial QT prolongation in the ECG and syncope are presented. A recently suggested mechanism of the syndrome is presented and preventive measures to reduce the risk of sudden death associated with it are proposed.

Published
1975
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7. Sudden coronary death in Scandinavia. A report from Scandinavian coronary heart disease registers

Author

Eino Linko, Lars Wilhelmsen, Pentti Siltanen, Matti Romo, Gösta Tibblin, and Curt Furberg

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Population, Myocardial Infarction, Disease, World Health Organization, Sudden death, Death, Sudden, Sex Factors, Age groups, Case fatality rate, Internal Medicine, Medicine, Humans, Myocardial infarction, education, Finland, Sweden, education.field_of_study, business.industry, Incidence (epidemiology), Age Factors, Middle Aged, medicine.disease, Coronary heart disease, Acute Disease, Female, business
Abstract

UNLABELLED All cases of acute myocardial infarction (AMI) and sudden death due to coronary heart disease have been registered in two Swedish and two Finnish cities during a 1-year period. The incidence increased steeply with age in both sexes and was in all age groups far higher in males than in females. The age-related incidence in both Finnish cities was definitely higher than in Gothenburg, Sweden, while the other Swedish register city, Boden, had an intermediate position. THE CASE fatality rate within one year was 44.2% for males and 37.4% for females. This difference was already apparent in the first hour after the onset of the attack, when the case: fatality rate was 15.5% for males and 9.3% for females. A history of previous cardiovascular disease was much more common in AMI patients than in the general population. It was also slightly more common in subjects who died suddenly than in AMI patients who did not die suddenly.

Published
1977

8. Adrenergic beta-receptor blockade and anaerobic metabolism

Author

Curt Furberg

Subjects
medicine.medical_specialty, Multidisciplinary, Glycogenolysis, Sympathetic Nervous System, Adrenergic receptor, Sensory Receptor Cells, Chemistry, Physical Exertion, Blood sugar, Adrenergic, Propranolol, Blockade, Endocrinology, Internal medicine, medicine, Blood lactate, Lactates, Humans, Anaerobic exercise, Glycolysis
Abstract

IT is known that adrenaline accelerates glycogenolysis in liver and in muscles, which leads to an elevation of the concentration of blood sugar and blood lactate1. During work (and especially with high work loads) there is a substantial increase in the concentration of blood lactate, which is mainly produced in the working muscles2. This can in part arise from increased adrenergic activity during work. The purpose of the present investigation was to test this assumption by means of an adrenergic beta-blocking agent.

Published
1966

9. The effect of a ganglionic blocking agent (chlorisondamine) on electrocardiogram, physical working capacity and hemodynamics in patients with vasoregulatory asthenia

Author

Curt Furberg, Håkan Linderholm, and O. Arvedson

Subjects
Adult, Male, Cardiac Catheterization, Heart Diseases, Posture, Hemodynamics, Working capacity, Blood Pressure, Chlorisondamine, chemistry.chemical_compound, Oxygen Consumption, Internal Medicine, Medicine, Humans, In patient, Cardiac Output, Pulse, Neurocirculatory Asthenia, Ganglionic blocking agent, business.industry, Electroencephalography, Middle Aged, chemistry, Anesthesia, Exercise Test, Female, business
Published
1967

10. Adrenergic beta-blockade and electrocardiographical ST-T changes

Author

Curt Furberg

Subjects
Adult, medicine.medical_specialty, Sympathetic Nervous System, Adolescent, business.industry, Myocardial Infarction, Adrenergic, Middle Aged, Propranolol, Blockade, Diagnosis, Differential, Electrocardiography, Myocarditis, Endocrinology, Internal medicine, Internal Medicine, medicine, Exercise Test, Humans, Nervous System Diseases, Beta (finance), business, Child, Pulse
Published
1967

11. Effect of aptin, a beta-adrenergic blocking agent, in arterial hypertension

Author

G. Michaelson and Curt Furberg

Subjects
Drug, Adult, Male, medicine.medical_specialty, Cardiac Volume, media_common.quotation_subject, Adrenergic beta-Antagonists, Blood Pressure, Prehypertension, Heart Rate, Internal medicine, Heart rate, Internal Medicine, medicine, Humans, Sympatholytics, Adverse effect, media_common, Aged, Clinical Trials as Topic, business.industry, Body Weight, Arteries, Middle Aged, Amino Alcohols, Blood pressure, Anesthesia, Hypertension, Cardiology, Exercise Test, Female, business
Abstract

The antihypertensive effect of a new beta-adrenergic blocking agent, Aptin, has been studied in a group of 12 patients with moderate arterial hypertension. The trial was carried out using a conventional double-blind cross-over design. A significant reduction of 18 mm Hg in the systolic blood pressure at rest was recorded for the entire group. The corresponding decrease of 7 mm Hg in the distolic pressure was not significant. During exercise a more pronounced reduction was recorded than at rest. The correlation found between the reduction in systolic blood pressure and heart rate during exercise during the Aptin treatment was probably significant. The antihypertensive effect of Aptin was considered as moderate. The drug may be of therapeutic value in combination with other antihypertensive drugs. No significant adverse effects or changes in results of laboratory tests were noted during the Aptin treatment.

Published
1969

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