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3 results on '"Buonaiuto, V"'

1. Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry

Author

Julio César Blázquez Encinar, Francisco Javier Martínez-Marcos, María Esther Guisado Espartero, J. Peña, Davide Luordo, Ricardo Gómez Huelgas, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Jeffrey Oskar Magallanes Gamboa, Raquel Gómez Méndez, Natalia Vicente López, Carlos Jorge Ripper, Luis M. Pérez-Belmonte, Joaquim Fernández Sola, Andrés de la Peña Fernández, Jose Javier Napal Lecumberri, María Gloria Rojano Rivero, José Manuel Ramos Rincón, Paula Maria Pesqueira Fontan, Francisco Javier Carrasco-Sánchez, Mª Dolores López-Carmona, Verónica Buonaiuto, Berta Román Bernal, Francisco Amorós Martínez, Alicia Hidalgo-Jiménez, SEMI-COVID-19 Network, [Carrasco-Sánchez,FJ, Hidalgo-Jiménez,A] Internal Medicine Department, Juan Ramón Jiménez University Hospital, Huelva, Spain. [López-Carmona,MD, Pérez-Belmonte,LM, Buonaiuto,V, Gómez Huelgas,R] Internal Medicine Department, Málaga Regional University Hospital, Málaga, Spain. [Martínez-Marcos,FJ] Clinical Infectious Disease Unit, Juan Ramón Jiménez University Hospital, Huelva, Spain. [Suárez Fernández,C] Internal Medicine Department, La Princesa University Hospital, Madrid, Spain. [Freire Castro,SJ] Internal Medicine Department, A Coruña University Hospital, A Coruña, Spain. [Luordo,D] Internal Medicine Department, Infanta Cristina University Hospital, Parla, Spain. [Pesqueira Fontan,PM] Internal Medicine Department, Santiago Clinical Hospital, Santiago de Compostela, Santiago, Spain. [Blázquez Encinar,JC] Internal Medicine Department, Torrevieja University Hospital, Torrevieja, Spain. [Magallanes Gamboa,JO] Internal Medicine Department, Nuestra Señora del Prado Hospital, Talavera de la Reina, Spain. [de la Peña Fernández,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Torres Peña,JD] Lipis and Atherosclerosis Unit, Department of Interna Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Spain. [Torres Peña,JD] CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), Insituto de Salud Carlos III, Córdoba, Spain. [Fernández Solà,J] Internal Medicine Department, Barcelona Clinical Hospital, Barcelona, Spain. [Napal Lecumberri,JJ] Internal Medicine Department, Marqués de Valdecilla University Hospital, Santander, Spain. [Amorós Martínez,F] Internal Medicine Department, Vinalopó University Hospital, Elche, Spain. [Guisado Espartero,ME] Internal Medicine Department, Infanta Margarita Hospital, Cabra, Spain. [Jorge Ripper,C] Internal Medicine Department, Insular de Gran Canaria Hospital, Las Palmas de Gran Canaria, Spain. [Gómez Méndez] Internal Medicine Department, Lucus Augusti University Hospital, Lugo, Spain. [Vicente López,N] Internal Medicine Department, Sureste University Hospital, Arganda del Rey, Spain. [Román Bernal,B] Internal Medicine Department, Doctor José Molina Orosa Hospital, Arrecife, Spain. [Rojano Rivero,MG] Internal Medicine Department, Infanta Elena Hospital, Huelva Hospital, Huelva, Spain. [Ramos Rincón,JM] Internal Medicine Department, Alicante General University Hospital, Alicante, Spain., and The study was completely support by the Spanish Federation of Internal Medicine.

Subjects
Blood Glucose, Male, sistema de registros, humanos, asistencia del enfermo crítico, pandemias, Diseases::Virus Diseases::Pneumonia, Viral [Medical Subject Headings], 030204 cardiovascular system & hematology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Respiratory Therapy::Respiration, Artificial [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, duración de estancia hospitalaria, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Length of Stay [Medical Subject Headings], Pandemic, Medicine, Hyperglycaemia, Registries, 030212 general & internal medicine, Hiperglucemia, mediana edad, Aged, 80 and over, anciano, diabetes, Respiration, respiración, Diabetes, General Medicine, Middle Aged, Original Article, Female, Coronavirus Infections, infecciones por Coronavirus, Research Article, medicine.medical_specialty, 2019-20 coronavirus outbreak, glucosa sanguínea, Critical Care, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, 03 medical and health sciences, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysis [Medical Subject Headings], Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperglycemia [Medical Subject Headings], Internal medicine, Diabetes mellitus, Humans, In patient, Risk factor, Mortality, hiperglucemia, Pandemics, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, SARS-CoV-2, Diseases::Endocrine System Diseases::Diabetes Mellitus [Medical Subject Headings], Diabetes status, COVID-19, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], neumonía, Pneumonia, Length of Stay, medicine.disease, mortality, Respiration, Artificial, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Spain, Hyperglycemia, Mortalidad, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings], business, hyperglycaemia
Abstract

Background Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. Methods This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: 180 mg/dL. The primary endpoint was all-cause in-hospital mortality. Results Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (180 mg/dL), p.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. Conclusions Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. KEY MESSAGE Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes., The study was completely support by the Spanish Federation of Internal Medicine.

Published
2020

2. Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification

Author

Angel Ramon Romance-Garcia, M. Rosa Bernal-Lopez, Verónica Buonaiuto, Antonio Vargas-Candela, Ricardo Gómez-Huelgas, M. Isabel Ruiz-Moreno, Alejandro Ruiz-Moreno, Javier Benítez-Porres, Cristina Gallardo-Escribano, Alberto Vilches-Perez, [Gallardo-Escribano,C] Clinical Analysis Department, Regional University Hospital of Malaga, Malaga, Spain. [Buonaiuto,V, Ruiz-Moreno,MI, Vargas-Candela,A, Ruiz-Moreno,A, Gomez-Huelgas,R, Bernal-Lopez,MR] Internal Medicine Department, Instituto de Investigación Biomédica de Malaga (IBIMA), Regional University Hospital of Malaga, Malaga, Spain. [Vilches-Perez,A] Endocrinology and Nutrition Department, Instituto de Investigación Biomédica de Malaga (IBIMA), University Hospital Virgen de la Victoria, Malaga, Spain. [Benitez-Porres,J] Department of Human Physiology, Physical Education and Sports. Faculty of Medicine, University of Malaga, Malaga, Spain. [Romance-Garcia,AR] Biodynamic and Body Composition Laboratory. Department of Didactics of Language, Arts, and Sport. Faculty of Education Science, University of Málaga, Malaga, Spain. [Gomez-Huelgas,R, Bernal-Lopez,MR] CIBER Patofisiología de la Obesidad y la Nutrición, Carlos III Health Institute, Madrid, Spain., and This work was supported by grants from the Instituto de Salud Carlos III, cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER ('Centros de Investigación En Red' (CIBER, CB06/03/0018)). M Rosa Bernal-Lopez was supported by 'Miguel Servet Type I' program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER.

Subjects
Epigenomics, Male, 0301 basic medicine, Lifestyle modification, Obesidad, Type 2 diabetes, Diet, Mediterranean, Body Mass Index, Epigenesis, Genetic, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism [Medical Subject Headings], Metabolically healthy obesity, Prepubertal population, Child, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, Mediterranean [Medical Subject Headings], Genetics (clinical), education.field_of_study, Inflammatory profile, Lipid profile, Cardiovascular Diseases, Child, Preschool, Metilación, Niño, DNA methylation, Lípidos, Homeostatic model assessment, Female, Niño preescolar, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Mass Index [Medical Subject Headings], Population, Check Tags::Male [Medical Subject Headings], Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Puberty [Medical Subject Headings], 030209 endocrinology & metabolism, Methylation, 03 medical and health sciences, Insulin resistance, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings], Internal medicine, Genetics, medicine, Humans, Persons::Persons::Age Groups::Child [Medical Subject Headings], Epigenetics, Obesity, Obesidad metabólica benigna, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics::Epigenomics [Medical Subject Headings], education, Exercise, Molecular Biology, Diseases::Cardiovascular Diseases [Medical Subject Headings], Inflammation, Obesity, Metabolically Benign, Inflamación, business.industry, Research, Puberty, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic [Medical Subject Headings], dNaM, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], DNA Methylation, Lipid Metabolism, medicine.disease, 030104 developmental biology, Endocrinology, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Risk Reduction Behavior [Medical Subject Headings], Diabetes Mellitus, Type 2, Check Tags::Female [Medical Subject Headings], Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Exercise [Medical Subject Headings], Insulin Resistance, Estilo de vida saludable, business, Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::DNA Methylation [Medical Subject Headings], Risk Reduction Behavior, Persons::Persons::Age Groups::Child::Child, Preschool [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Developmental Biology
Abstract

Background Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or cardiovascular disease). MHO is closely related to lifestyle and environmental factors. Epigenetics has become an essential biological tool to analyze the link between obesity and metabolic status. The aim of this study was to determine whether MHO status is conditioned by the DNA methylation (DNAm) of several genes related to lipid metabolism (lipoprotein lipase, retinoid X receptor alpha, liver X receptor, stearoyl-CoA desaturase, sterol regulatory element binding factor 1), and inflammation (LEP) in peripheral blood mononuclear cells (PBMCs) from 131 prepubertal subjects with MHO phenotype after lifestyle modifications with personalized Mediterranean diet (MedDiet) combined with a physical activity (PA) program. Results The DNAm of all studied genes were significantly modified in the population after 12 months of lifestyle modifications (MedDiet and PA). In addition, associations were found between the DNAm studies and BMI, homeostatic model assessment of insulin resistance, monounsaturated fatty acid and polyunsaturated fatty acid, moderate-vigorous PA, fat mass, and adherence to MedDiet. Conclusions It was found that DNAm of genes related to lipid metabolism and inflammation are also present in childhood and that this methylation profile can be modified by interventions based on MedDiet and PA.

Published
2020

3. Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population

Author

María Rosa Bernal-López, Verónica Buonaiuto, Josefina Ruiz-Nava, Dariusz Narankiewicz, Luis M. Pérez-Belmonte, Maria Isabel Ruiz-Moreno, Ricardo Gómez-Huelgas, María D. López-Carmona, [Narankiewicz,D] Preventive Medicine Department, Virgen de la Victoria University Hospital, Malaga, Spain. [Ruiz-Nava,J, Buonaiuto,V, Ruiz-Moreno,MI, López-Carmona,MD, Pérez-Belmonte,LM, Gómez-Huelgas,R, Bernal-López,MR] Internal Medicine Department, Regional University Hospital of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Malaga, Spain. [Gómez-Huelgas,R, Bernal-López,MR] Ciber Fisiopatología de la Obesidad y Nutrición. Instituto de Salud Carlos III, Madrid, Spain., and This work was supported by grants from the Instituto de Salud Carlos III, cofinancial by the Fondo Europeo de Desarrollo Regional-FEDER (PI12/01373 and 'Centros de Investigación En Red' (CIBER, CB06/03/0018)), and from the Consejería de Economía, Innovación, Ciencia y Empleo-FEDER (P07-CTS 656 and CTS-1023, Junta de Andalucía, Spain). María Rosa Bernal-Lopez was supported by 'Miguel Servet Type I' program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER.

Subjects
Male, Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], Health, Toxicology and Mutagenesis, lcsh:Medicine, Type 2 diabetes, Overweight, Índice de masa corporal, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Liver Function Tests, Risk Factors, Liver function tests, Body mass index, education.field_of_study, medicine.diagnostic_test, diabetes, Fatty liver, Diabetes, Enfermedad del hígado graso no alcohólico, Lipids, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Phenotype, Lípidos, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], 030211 gastroenterology & hepatology, Female, medicine.symptom, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Digestive System::Liver Function Tests [Medical Subject Headings], Adult, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Mass Index [Medical Subject Headings], Population, Check Tags::Male [Medical Subject Headings], 030209 endocrinology & metabolism, body mass index, Article, lipids, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Prediabetic State [Medical Subject Headings], 03 medical and health sciences, Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings], Internal medicine, Diabetes mellitus, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight [Medical Subject Headings], medicine, Humans, education, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Hypertriglyceridemia, fungi, lcsh:R, Public Health, Environmental and Occupational Health, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under Curve [Medical Subject Headings], Andalucía, Pruebas de función hepática, medicine.disease, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::Hypercholesterolemia [Medical Subject Headings], Endocrinology, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Andalusian, Check Tags::Female [Medical Subject Headings], Spain, business, Non-alcoholic fatty liver disease
Abstract

The aim of this study was to analyze the utility of liver function tests (LFT) and fatty liver index (FLI), a surrogate marker of non-alcoholic fatty liver disease, in the categorization of metabolic phenotypes in a Mediterranean population. A cross-sectional study was performed on a random representative sample of 2233 adults assigned to a health center in M&aacute, laga, Spain. The metabolic phenotypes were determined based on body mass index (BMI) categorization and the presence or absence of two or more cardiometabolic abnormalities (high blood pressure, low high-density lipoprotein (HDL) cholesterol, hypertriglyceridemia, pre-diabetes) or type 2 diabetes. No difference was observed between metabolically healthy and metabolically abnormal phenotypes on LFT. The mean FLI of the population was 41.1 &plusmn, 28.6. FLI was significantly higher (p &lt, 0.001) in the metabolically abnormal phenotypes in all BMI categories. The proportion of individuals with pathological FLI (&ge, 60) was significantly higher in the metabolically abnormal overweight and obese phenotypes (p &lt, 0.001). On a multivariate model adjusted for sex, age, and waist circumference, a significant correlation was found between pathological FLI and metabolically abnormal phenotypes in the overweight and obese BMI categories. Area under the curve (AUC) of FLI as a biomarker was 0.76, 0.74, and 0.72 for the metabolically abnormal normal-weight, overweight, and obese groups, respectively. Liver biochemistry is poorly correlated with metabolic phenotypes. Conversely, a good correlation between FLI, as a marker of non-alcoholic fatty liver disease (NAFLD), and metabolically abnormal phenotypes in all BMI ranges was found. Our study suggests that FLI may be a useful marker for characterizing metabolically abnormal phenotypes in individuals who are overweight or obese.

Published
2020

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