1. [Levels of immunoreactive cytokines in serum of women with preeclampsia or severe pregnancy hypertension]
- Author
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Urszula, Tarnowska-Madra, Jerzy, Leibschang, Bozena, Kowalska, Ewa, Filipp, Agata, Kozar, Anna, Nimer, and Tomasz, Maciejewski
- Subjects
Adult ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Postpartum Period ,Interleukin-18 ,Hypertension, Pregnancy-Induced ,Th1 Cells ,Severity of Illness Index ,Interleukin-10 ,Young Adult ,Th2 Cells ,Pre-Eclampsia ,Pregnancy ,Case-Control Studies ,Cytokines ,Humans ,Interleukin-2 ,Female ,Interleukin-4 - Abstract
The purpose of the study was to compare concentrations of inflammatory and Th1/Th2 cytokines in serum obtained from women with preeclampsia or severe pregnancy hypertension versus normotensive controls.The study group consisted of 34 pregnant women with hypertension over 140/90mmHg and proteinuria over 0.3 g/day or severe pregnancy hypertension. 16 healthy pregnant women comprised the control group. The concentration of IL-2, IL-4, IL-6, IL-10, TNFalpha and IFNgamma was measured with Cytometric Bead Array Human Th1/Th2 Cytokine Kit II (Becton Dickinson). U-Mann Whitney test was used for the comparison of the results.We found statistically significantly increased concentrations of IFNgamma: 8.4 +/- 5.3 pg/ml vs. 4.2 +/- 3.2 pg/ml (p = 0.02), TNFalpha: 1.5 +/- 0.7 pg/ml vs. 0.7 +/- 0.3 pg/ml (p = 0.04) and IL-2: 1.3-0.6 pg/ml vs. 0.6 +/- 0.4 pg/ml (p = 0.01) in the studied group. The level of IL-6 35.5 +/- 21.0 pg/ml vs. 19.8 +/- 12.3 pg/ml was also increased but the difference did not reach statistical significance. Concentrations of IL-4 and IL- 10 were similar in both groups.Increased concentrations of Th1 cytokines (IFNgamma, IL-2) in the serum of women with preeclampsia suggests an exaggerated cytotoxic activity of blood in this pathology accompanied by an increase in the levels of inflammatory cytokines TNFalpha and IL-6.
- Published
- 2010