1. IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy.
- Author
-
Hagge DA, Scollard DM, Ray NA, Marks VT, Deming AT, Spencer JS, and Adams LB
- Subjects
- Animals, Disease Models, Animal, Female, Interleukin-10 genetics, Mice, Mice, Knockout, Nitric Oxide Synthase Type II genetics, Antigens, Bacterial immunology, CD4-Positive T-Lymphocytes immunology, Interleukin-10 immunology, Leprosy immunology, Mycobacterium leprae immunology, Nitric Oxide Synthase Type II immunology
- Abstract
Background: Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous lesion can occur. The evolution and maintenance of chronic inflammatory processes like those observed in the leprosy granuloma involve an ongoing network of communications via cytokines. IL-10 has immunosuppressive properties and IL-10 genetic variants have been associated with leprosy development and reactions., Methodology/principal Findings: The role of IL-10 in resistance and inflammation in leprosy was investigated using Mycobacterium leprae infection of mice deficient in IL-10 (IL-10-/-), as well as mice deficient in both inducible nitric oxide synthase (NOS2-/-) and IL-10 (10NOS2-/-). Although a lack of IL-10 did not affect M. leprae multiplication in the footpads (FP), inflammation increased from C57Bl/6 (B6)
- Published
- 2014
- Full Text
- View/download PDF