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Start Over Author "Montez J" Topic intercellular signaling peptides and proteins
2 results on '"Montez J"'

1. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin.

Author

Sennello JA, Fayad R, Morris AM, Eckel RH, Asilmaz E, Montez J, Friedman JM, Dinarello CA, and Fantuzzi G

Subjects
Adiponectin, Animals, Apoptosis, Autoimmune Diseases chemically induced, CCAAT-Enhancer-Binding Proteins genetics, Concanavalin A, Cytokines biosynthesis, DNA-Binding Proteins genetics, In Situ Nick-End Labeling, Intercellular Signaling Peptides and Proteins blood, Intercellular Signaling Peptides and Proteins pharmacology, Killer Cells, Natural immunology, Leptin blood, Leptin deficiency, Leptin pharmacology, Lipodystrophy genetics, Lipodystrophy immunology, Lymphocyte Activation, Mice, Mice, Obese, Mice, Transgenic, Obesity immunology, Sterol Regulatory Element Binding Protein 1, Transcription Factors genetics, Tumor Necrosis Factor-alpha physiology, Hepatitis immunology, Intercellular Signaling Peptides and Proteins physiology, Leptin physiology, T-Lymphocytes immunology
Abstract

Concanavalin A-induced hepatotoxicity was compared in lipodystrophic aP2-nSREBP-1c transgenic mice (LD mice) lacking adipose tissue, obese leptin-deficient ob/ob mice, and lean wild-type (WT) mice. Serum leptin and adiponectin were low in LD mice, whereas ob/ob mice had undetectable leptin, but high adiponectin. Protection from hepatotoxicity was observed in ob/ob, but not in LD mice, despite low cytokine levels and reduced T cell activation and hepatic natural killer T cells in both groups. Administration of adiponectin protected LD mice from hepatotoxicity without altering cytokine levels. In contrast, administration of leptin heightened disease susceptibility by restoring cytokine production. Neutralization of TNF alpha protected LD mice from liver damage. Increased in vivo susceptibility to the hepatotoxic effect of TNF alpha was observed in LD mice. In vitro, adiponectin protected primary hepatocytes from TNF alpha-induced death, whereas leptin had no protective effect. In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death.

Published
2005
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2. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin

Author

Robert H. Eckel, Alison M. Morris, Jeffrey M. Friedman, Charles A. Dinarello, Raja Fayad, Jason M. Montez, Giamila Fantuzzi, Esra Asilmaz, Joseph A. Sennello, Coates, Alison Mary, Sennello, J, Fayad, R, Eckel, R, Asilmaz, E, Montez, J, Friedman, J, Dinarello, C, and Fantuzzi, G

Subjects
Leptin, medicine.medical_specialty, Lipodystrophy, T-Lymphocytes, medicine.medical_treatment, T cell, Mice, Obese, Adipose tissue, Adipokine, Apoptosis, Mice, Transgenic, Biology, Lymphocyte Activation, Autoimmune Diseases, Hepatitis, Mice, Endocrinology, Internal medicine, Concanavalin A, In Situ Nick-End Labeling, medicine, Animals, Obesity, Leptin Deficiency, Adiponectin, Tumor Necrosis Factor-alpha, Natural killer T cell, DNA-Binding Proteins, Killer Cells, Natural, Cytokine, medicine.anatomical_structure, CCAAT-Enhancer-Binding Proteins, Cytokines, Intercellular Signaling Peptides and Proteins, Sterol Regulatory Element Binding Protein 1, hormones, hormone substitutes, and hormone antagonists, Transcription Factors
Abstract

Concanavalin A-induced hepatotoxicity was compared in lipodystrophic aP2-nSREBP-1c transgenic mice (LD mice) lacking adipose tissue, obese leptin-deficient ob/ob mice, and lean wild-type (WT) mice. Serum leptin and adiponectin were low in LD mice, whereas ob/ob mice had undetectable leptin, but high adiponectin. Protection from hepatotoxicity was observed in ob/ob, but not in LD mice, despite low cytokine levels and reduced T cell activation and hepatic natural killer T cells in both groups. Administration of adiponectin protected LD mice from hepatotoxicity without altering cytokine levels. In contrast, administration of leptin heightened disease susceptibility by restoring cytokine production. Neutralization of TNFα protected LD mice from liver damage. Increased in vivo susceptibility to the hepatotoxic effect of TNFα was observed in LD mice. In vitro, adiponectin protected primary hepatocytes from TNFα-induced death, whereas leptin had no protective effect. In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNFα-induced death.

Published
2005

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