1. The effect of quinapril treatment on insulin resistance, leptin and high sensitive C-reactive protein in hypertensive patients.
- Author
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Sari F, Eray E, and Sari R
- Subjects
- Adult, Aged, Antihypertensive Agents administration & dosage, Blood Pressure drug effects, Female, Homeostasis drug effects, Humans, Inflammation drug therapy, Inflammation metabolism, Male, Middle Aged, Quinapril, Treatment Outcome, C-Reactive Protein metabolism, Hypertension drug therapy, Hypertension metabolism, Insulin Resistance, Leptin blood, Tetrahydroisoquinolines administration & dosage
- Abstract
The aim of the study was to evaluate the effect of quinapril on HOMA-IR, high sensitive C-reactive protein and leptin. Total 54 hypertensive and 24 control subjects were included in this study. Blood pressure, leptin, high sensitive C-reactive protein, and HOMA-IR were determined at baseline and after 3 months quinapril treatment. After treatment with quinapril HOMA-IR (p = 0.04), high sensitive C-reactive protein (p = 0.027), and leptin (p = 0.046) were decreased in hypertensive patients. Quinapril may be used as a therapy for improving blood pressure as well as the insulin resistant, hyperleptinemic, and low-grade inflammatory state in hypertension.
- Published
- 2011
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