1. Use of lispro insulin for treatment of diabetic ketoacidosis in cats
- Author
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Sara Corradini, Francesca Del Baldo, G. Carotenuto, Massimo Giunti, Michela Mazzarino, Federico Fracassi, Eleonora Malerba, Malerba, Eleonora, Mazzarino, Michela, Del Baldo, Francesca, Corradini, Sara, Carotenuto, Gaia, Giunti, Massimo, and Fracassi, Federico
- Subjects
medicine.medical_specialty ,endocrine system ,Diabetic ketoacidosis ,endocrine system diseases ,040301 veterinary sciences ,medicine.medical_treatment ,Blood sugar ,Cat Diseases ,Gastroenterology ,030308 mycology & parasitology ,0403 veterinary science ,Small Animal ,03 medical and health sciences ,diabetic ketoacidosis ,Polyuria ,Diabetes mellitus ,Internal medicine ,medicine ,Insulin lispro ,Animals ,Hypoglycemic Agents ,lispro insulin ,Small Animals ,0303 health sciences ,Insulin Lispro ,business.industry ,Insulin ,nutritional and metabolic diseases ,04 agricultural and veterinary sciences ,medicine.disease ,Regular insulin ,Cats ,Ketosis ,medicine.symptom ,business ,medicine.drug - Abstract
Objectives The aim of this study was to evaluate the efficacy and safety of lispro insulin for the treatment of feline diabetic ketoacidosis (DKA). Times to resolution of hyperglycaemia, ketosis and acidosis were compared between cats treated with continuous rate infusion (CRI) of lispro insulin and cats treated with CRI of regular insulin. Methods Client-owned cats with naturally occurring DKA, newly diagnosed with diabetes mellitus (DM) or already receiving treatment for DM, were included. Diagnosis of DKA involved the presence of at least two clinical signs consistent with DKA (eg, polyuria/polydipsia, anorexia, severe lethargy, vomiting and dehydration), blood glucose (BG) concentration >13.9 mmol/l (>250 mg/dl), blood beta hydroxybutyrate (BHB) concentration >2.5 mmol/l and venous pH 13.9 mmol/l [>250 mg/dl]), ketosis (BHB concentration >1 mmol/l) and acidosis (venous pH Results Eighteen DKA cases (nine per group) were enrolled into the study. There were no significant differences in the median time to resolution of three variables (hyperglycaemia, ketosis and acidosis) between the two groups. Two cats in group R developed hypoglycaemia during the CRI of insulin. One cat in group L and three cats in group R developed hypophosphataemia, which required phosphate supplementation. Conclusions and relevance IV CRI of lispro insulin has few side effects and appears to be as effective as IV CRI of regular insulin in the treatment of cats with DKA.
- Published
- 2019