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Start Over Author "Fioretto, Laura" Topic innate immunity
3 results on '"Fioretto, Laura"'

2. Chemical Synthesis of Marine-Derived Sulfoglycolipids, a New Class of Molecular Adjuvants.

Author

Manzo, Emiliano, Fioretto, Laura, Pagano, Dario, Nuzzo, Genoveffa, Gallo, Carmela, Fontana, Angelo, and De Palma, Raffaele

Abstract

Vaccines play a primary role in the protection of human health by preventing infectious and chronic diseases. Recently we have reported 1,2-O-distearoyl-3-O-β-d-sulfoquinovosylglycerol (β-SQDG18), here named Sulfavant A (1), which shows promising properties as a new molecular adjuvant in in vitro and in vivo tests. In the present manuscript, we provide full details about a synthetic strategy for the preparation of 1, including a discussion of chemical determinants of the activity and the major technical hurdles we faced during the study. Synthesis of Sulfavant A (1) is achieved by a versatile procedure based on a trichloroacetimidate methodology and peracetate sugar precursors. The final design opens possibilities for the preparation of a series of interesting analogs for further pharmacological optimization and development, including derivatives containing different saturated and polyunsaturated fatty acids (e.g., 17 and 22). [ABSTRACT FROM AUTHOR]

Published
2017
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3. Chemical Synthesis of Marine-Derived Sulfoglycolipids, a New Class of Molecular Adjuvants

Author

Dario Pagano, Angelo Fontana, Laura Fioretto, Emiliano Manzo, Raffaele De Palma, Carmela Gallo, Genoveffa Nuzzo, Manzo, Emiliano, Fioretto, Laura, Pagano, Dario, Nuzzo, Genoveffa, Gallo, Carmela, De Palma, Raffaele, Fontana, A, DE PALMA, Raffaele, and Fontana, Angelo

Subjects
0301 basic medicine, Aquatic Organisms, glycolipids, sulfolipid, dendritic cell, medicine.medical_treatment, Pharmaceutical Science, Sulfoglycolipids, Biology, In vivo tests, Chemical synthesis, Article, immunology, 03 medical and health sciences, Human health, Adjuvants, Immunologic, adjuvant, vaccine, Drug Discovery, medicine, Animals, dendritic cells, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), innate immunity, lcsh:QH301-705.5, Adjuvants, Pharmaceutic, Vaccines, Sulfavant A, immunogenic lipid, Primary (chemistry), Combinatorial chemistry, 030104 developmental biology, Biochemistry, lcsh:Biology (General), glycolipid, Adjuvant
Abstract

Vaccines play a primary role in the protection of human health by preventing infectious and chronic diseases. Recently we have reported 1,2-O-distearoyl-3-O-beta-d-sulfoquinovosylglycerol (beta-SQDG18), here named Sulfavant A (1), which shows promising properties as a new molecular adjuvant in in vitro and in vivo tests. In the present manuscript, we provide full details about a synthetic strategy for the preparation of 1, including a discussion of chemical determinants of the activity and the major technical hurdles we faced during the study. Synthesis of Sulfavant A (1) is achieved by a versatile procedure based on a trichloroacetimidate methodology and peracetate sugar precursors. The final design opens possibilities for the preparation of a series of interesting analogs for further pharmacological optimization and development, including derivatives containing different saturated and polyunsaturated fatty acids (e.g., 17 and 22).

Published
2017

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