1. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus.
- Author
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Mao-Juan Zhang, Bing Liu, Shang-Gao Liao, You-Kai Xu, De-Qiang Feng, Kai-Long Ji, and Yan Li
- Subjects
TRITERPENOIDS ,BIOSYNTHESIS ,INHIBITORY postsynaptic potential ,NITRIC oxide synthesis ,MACROPHAGE activation - Abstract
Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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