1. Diversity of the microbiota communities found in the various regions of the intestinal tract in healthy individuals and inflammatory bowel diseases.
- Author
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Lawal SA, Voisin A, Olof H, Bording-Jorgensen M, and Armstrong H
- Subjects
- Humans, Inflammatory Bowel Diseases microbiology, Crohn Disease microbiology, Colitis, Ulcerative microbiology, Microbiota, Gastrointestinal Microbiome, Viruses
- Abstract
The severe and chronic inflammatory bowel diseases (IBD), Crohn disease and ulcerative colitis, are characterized by persistent inflammation and gut damage. There is an increasing recognition that the gut microbiota plays a pivotal role in IBD development and progression. However, studies of the complete microbiota composition (bacteria, fungi, viruses) from precise locations within the gut remain limited. In particular, studies have focused primarily on the bacteriome, with available methods limiting evaluation of the mycobiome (fungi) and virome (virus). Furthermore, while the different segments of the small and large intestine display different functions ( e.g. , digestion, absorption, fermentation) and varying microenvironment features ( e.g. , pH, metabolites), little is known about the biogeography of the microbiota in different segments of the intestinal tract or how this differs in IBD. Here, we highlight evidence of the differing microbiota communities of the intestinal sub-organs in healthy and IBD, along with method summaries to improve future studies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Lawal, Voisin, Olof, Bording-Jorgensen and Armstrong.)
- Published
- 2023
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