1. Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.
- Author
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Zhang, Zhongwei, Tanaka, Izumi, Nakahashi-Ouchida, Rika, Ernst, Peter, Kiyono, Hiroshi, and Kurashima, Yosuke
- Subjects
Anti-GP2 autoantibodies ,Glycoprotein 2 ,Inflammatory bowel disease ,Mucosal immunology ,Pancreas ,Pancreas-gut axis ,Animals ,Humans ,Autoantibodies ,Disease Susceptibility ,GPI-Linked Proteins ,Immunity ,Mucosal ,Inflammation ,Inflammatory Bowel Diseases ,Intestinal Mucosa - Abstract
Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.
- Published
- 2024