1. EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Author
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Zhou Q, Zhang Z, Wang P, Zhang B, Chen C, Zhang C, and Su Y
- Subjects
- Adult, Aged, Body Mass Index, Dietary Supplements, Double-Blind Method, Fatty Acids blood, Fatty Acids, Omega-3 metabolism, Fatty Acids, Omega-3 pharmacokinetics, Female, Humans, Hypercholesterolemia blood, Inflammation blood, Interleukin-6 blood, Male, Middle Aged, Placebo Effect, Placebos, Triglycerides blood, Tumor Necrosis Factor-alpha blood, alpha-Linolenic Acid pharmacokinetics, Docosahexaenoic Acids pharmacology, Eicosapentaenoic Acid pharmacology, Hypercholesterolemia diet therapy, Inflammation diet therapy, Lipids blood, alpha-Linolenic Acid pharmacology
- Abstract
Scope: To compare the effects of supplementary eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) versus α-linolenic acid (ALA) on lipid profiles, inflammatory status, and fatty acid composition of peripheral blood mononuclear cells (PBMCs) in hypercholesterolemic adults., Methods and Results: A randomized, controlled, double-blind trial is conducted to examine the effects of consumption of control oil, 4.2 g/d ALA, 7.2 g/d ALA, 1.8 g/d DHA+EPA, or 3.6 g/d EPA+DHA for 12 weeks on lipid profiles, fatty acid composition of PBMCs and in vitro production of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) by PBMCs in 123 subjects with hypercholesteremia. After the intervention, subjects who receive a low and high dose of DHA/EPA experience 11.99% and 15.78% decreases in triglycerides which is significantly different from that of the control group (p < 0.05). The in vitro study indicates that supplementation of high-dose DHA+EPA induces the greatest decrease of IL-6 production by PBMCs relative to other groups (p = 0.046). ALA intervention significantly increases the PBMCs composition of ALA but not EPA/DHA., Conclusion: EPA+DHA, but not ALA, improves lipids and inflammation status in hypercholesterolemic adults. Supplementation of ALA does not increase the PBMCs composition of EPA/DHA in middle-aged to elderly Chinese., (© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2019
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