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Purpose: The aim of this study was to investigate the relationship between vitamin D and novel inflammatory markers in hemodialysis patients., Methods: In total, 129 eligible maintenance hemodialysis patients were enrolled in this cross-sectional study. Patients were divided into two groups according to their serum vitamin D levels. A serum 25-hydroxyvitamin D (25(OH)D) level < 20 ng/ml was identified as vitamin D deficiency and a serum level ≥ 20 ng/ml was identified as normal. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated from the complete blood cell count. Spearman correlation analysis and both logistic and linear regression analyses were used to define the relationships between the study parameters., Results: The two groups showed statistically significant differences for gender and for C-reactive protein (CRP) and NLR values (p = 0.017, p = 0.010, and p = 0.013). Age and gender were independently associated with vitamin D deficiency (p = 0.003 and p = 0.030). Serum 25(OH)D levels showed significant but weak inverse correlations with CRP (r = - 0.205, p = 0.020) and with NLR (r = - 0.219, p = 0.013). Serum 25(OH)D levels also showed a significant but very weak correlation with PLR (r = - 0.182, p = 0.039). Serum 25(OH)D levels showed no correlation with mean platelet volume (p = 0.660). Gender was the only variable significantly associated with serum vitamin D levels, as determined by linear regression analysis (p = 0.003)., Conclusion: CRP levels and NLR values were significantly higher in the vitamin D deficiency group. A significant inverse correlation was found between serum vitamin D levels and CRP levels, and NLR and PLR values.

We aimed to investigate the relationship between RDW and serum CRP levels in maintenance hemodialysis patients. We enrolled 112 eligible maintenance hemodialysis patients in this retrospective study. Two groups were i dentified according to red cell distribution width (RDW) values: patients with normal RDW (RDW < 14.5%) and patients with elevated RDW (RDW ≥ 14.5%). Spearman correlation analysis and linear regression analysis were used to investigate the relationship between the study parameters. The only statistically significant difference between two groups was serum CRP levels (p= 0.007). Se rum albumin levels had significant but weak inverse correlation with serum CRP levels (r= -0.257, p= 0.006). RDW values had significant but weak positive correlation with serum CRP levels (r= 0.289, p= 0.002). We did not found a significant correlation between hemoglobin levels and serum CRP levels and serum ferritin levels and serum CRP levels (p= 0.090 and p= 0.664, respectively). We made multivariate linear regression analysis and RDW was detected as the only independently associated factor for serum CRP levels (p= 0.028). We found that there is a statistically significant positive correlation between CRP and RDW in maintenance hemodialysis patients. We also showed a significant relationship between RDW and serum CRP levels. We concluded that RDW can be used as an inflammatory marker for hemodialysis patients. [ABSTRACT FROM AUTHOR]