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Your search keyword '"Hasan H. Öz"' showing total 2 results
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2 results on '"Hasan H. Öz"'

1. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis

Author

Caterina, Di Pietro, Hasan H, Öz, Ping-Xia, Zhang, Ee-Chun, Cheng, Valentino, Martis, Tracey L, Bonfield, Thomas J, Kelley, Ronald, Jubin, Abraham, Abuchowski, Diane S, Krause, Marie E, Egan, Thomas S, Murray, and Emanuela M, Bruscia

Subjects
Inflammation, Lipopolysaccharides, Mice, Phosphatidylinositol 3-Kinases, Cystic Fibrosis, Animals, Pneumonia, Lung, Heme Oxygenase-1, Monocytes
Abstract

Overwhelming neutrophilic inflammation is a leading cause of lung damage in many pulmonary diseases, including cystic fibrosis (CF). The heme oxygenase-1 (HO-1)/carbon monoxide (CO) pathway mediates the resolution of inflammation and is defective in CF-affected macrophages (MΦs). Here, we provide evidence that systemic administration of PP-007, a CO releasing/O

Published
2022

2. Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis

Author

Hasan H. Öz, Ee-Chun Cheng, Caterina Di Pietro, Toma Tebaldi, Giulia Biancon, Caroline Zeiss, Ping-Xia Zhang, Pamela H. Huang, Sofia S. Esquibies, Clemente J. Britto, Jonas C. Schupp, Thomas S. Murray, Stephanie Halene, Diane S. Krause, Marie E. Egan, and Emanuela M. Bruscia

Subjects
History, Cystic Fibrosis, Polymers and Plastics, RNA biology, Cystic Fibrosis Transmembrane Conductance Regulator, lung remodeling, Monocytes, Industrial and Manufacturing Engineering, General Biochemistry, Genetics and Molecular Biology, cystic fibrosis, Mice, computational biology, neutrophils, Transforming Growth Factor beta, Immunology, c-c motif chemokine receptor 2, chronic lung inflammation, lipopolysaccharide, macrophages, monocytes, recruitment, transforming growth factor β, RNA-seq, single cell RNA-seq, omics, sequencing, network analysis [CP], Humans, Animals, Business and International Management, Lung, network analysis, Inflammation, Macrophages, Pneumonia, Immunology [CP], Receptors, Chemokine
Abstract

Persistent neutrophil-dominated lung inflammation contributes to lung damage in cystic fibrosis (CF). However, the mechanisms that drive persistent lung neutrophilia and tissue deterioration in CF are not well characterized. Starting from the observation that, in patients with CF, c-c motif chemokine receptor 2 (CCR2)

Published
2022
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