21 results on '"FitzGerald, Garret A"'
Search Results
2. Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice.
- Author
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Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, and Funk CD
- Subjects
- Animals, Inflammation chemically induced, Isoenzymes genetics, Isoenzymes metabolism, Lipopolysaccharides pharmacology, Mice, Mice, Inbred C57BL, Prostaglandin-Endoperoxide Synthases chemistry, Inflammation enzymology, Lipids analysis, Prostaglandin-Endoperoxide Synthases genetics, Prostaglandin-Endoperoxide Synthases metabolism
- Abstract
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2 , function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered. We used three engineered mouse lines where the Ptgs1 and Ptgs2 genes substitute for one another to discriminate the distinct roles and interchangeability of COX isoforms during systemic inflammation. In macrophages, kidneys, and lungs, "flipped" Ptgs genes generate a "reversed" COX expression pattern, where the knock-in COX-2 is expressed constitutively and the knock-in COX-1 is lipopolysaccharide inducible. A panel of eicosanoids detected in serum and kidney demonstrates that prostaglandin (PG) biosynthesis requires native COX-1 and cannot be rescued by the knock-in COX-2. Our data further reveal preferential compensation of COX isoforms for prostanoid production in macrophages and throughout the body, as reflected by urinary PG metabolites. NanoString analysis indicates that inflammatory networks can be maintained by isoform substitution in inflamed macrophages. However, COX-1>COX-2 macrophages show reduced activation of inflammatory signaling pathways, indicating that COX-1 may be replaced by COX-2 within this complex milieu, but not vice versa. Collectively, each COX isoform plays a distinct role subject to subcellular environment and tissue/cell-specific conditions, leading to subtle compensatory differences during systemic inflammation., (Copyright © 2018 by the American Society for Biochemistry and Molecular Biology, Inc.)
- Published
- 2018
- Full Text
- View/download PDF
3. Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System.
- Author
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Grosser T, Theken KN, and FitzGerald GA
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Cardiovascular Diseases chemically induced, Cardiovascular Diseases prevention & control, Cyclooxygenase Inhibitors adverse effects, Cyclooxygenase Inhibitors pharmacology, Gastrointestinal Diseases chemically induced, Gastrointestinal Diseases prevention & control, Humans, Inflammation pathology, Pain drug therapy, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Cyclooxygenase Inhibitors therapeutic use, Inflammation drug therapy
- Abstract
Inhibitors of the cyclooxygenases (COXs), the nonsteroidal antiinflammatory drugs (NSAIDs), relieve inflammatory pain, but are associated with gastrointestinal and cardiovascular complications. Given the widespread use of NSAIDs, there has been a longstanding interest in optimizing their risk-benefit ratio, for example by reducing their gastrointestinal risk. More recently, the focus has shifted toward the cardiovascular complications of NSAIDs and very large prospective studies have been performed to compare cardiovascular risk across distinct NSAIDs. Surprisingly, much less attention has been paid to the efficacy side of the risk-benefit ratio. There is marked variability in the degree of pain relief by NSAIDs due to the complex interplay of molecular mechanisms contributing to the pain sensation, variability in the disposition of NSAIDs, and imprecision in the quantification of human pain. Here we discuss how NSAIDs relieve pain, how molecular mechanisms relate to clinical efficacy, and how this may inform our interpretation of clinical trials., (© 2017 American Society for Clinical Pharmacology and Therapeutics.)
- Published
- 2017
- Full Text
- View/download PDF
4. Bioactive products formed in humans from fish oils.
- Author
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Skarke C, Alamuddin N, Lawson JA, Li X, Ferguson JF, Reilly MP, and FitzGerald GA
- Subjects
- Adult, Anti-Inflammatory Agents administration & dosage, CD59 Antigens administration & dosage, Fatty Acids, Omega-3 blood, Female, Healthy Volunteers, Humans, Inflammation blood, Inflammation chemically induced, Inflammation Mediators chemical synthesis, Lipopolysaccharides administration & dosage, Male, Dietary Supplements, Fish Oils administration & dosage, Inflammation diet therapy, Inflammation Mediators blood, Lipid Metabolism drug effects
- Abstract
Resolvins, maresins, and protectins can be formed from fish oils. These specialized pro-resolving mediators (SPMs) have been implicated in the resolution of inflammation. Synthetic versions of such SPMs exert anti-inflammatory effects in vitro and when administered to animal models. However, their importance as endogenous products formed in sufficient amounts to exert anti-inflammatory actions in vivo remains speculative. We biased our ability to detect SPMs formed in healthy volunteers by supplementing fish oil in doses shown previously to influence blood pressure and platelet aggregation under placebo-controlled conditions. Additionally, we sought to determine the relative formation of SPMs during an acute inflammatory response and its resolution, evoked in healthy volunteers by bacterial lipopolysaccharide (LPS). Bioactive lipids, enzymatic epoxyeicosatrienoic acids (EETs), and free radical-catalyzed prostanoids [isoprostanes (iPs)] formed from arachidonic acid and the fish oils, served as comparators. Despite the clear shift from ω-6 to ω-3 EETs and iPs, we failed to detect a consistent signal, in most cases, of SPM formation in urine or plasma in response to fish oil, and in all cases in response to LPS on a background of fish oil. Our results question the relevance of these SPMs to the putative anti-inflammatory effects of fish oils in humans., (Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc.)
- Published
- 2015
- Full Text
- View/download PDF
5. Prostaglandins and inflammation.
- Author
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Ricciotti E and FitzGerald GA
- Subjects
- Animals, Cyclooxygenase Inhibitors therapeutic use, Humans, Inflammation drug therapy, Prostaglandin-Endoperoxide Synthases metabolism, Receptors, Prostaglandin metabolism, Thromboxanes metabolism, Inflammation immunology, Inflammation Mediators metabolism, Prostaglandins metabolism, Signal Transduction drug effects
- Abstract
Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated from arachidonate by the action of cyclooxygenase isoenzymes, and their biosynthesis is blocked by nonsteroidal antiinflammatory drugs, including those selective for inhibition of cyclooxygenase-2. Despite the clinical efficacy of nonsteroidal antiinflammatory drugs, prostaglandins may function in both the promotion and resolution of inflammation. This review summarizes insights into the mechanisms of prostaglandin generation and the roles of individual mediators and their receptors in modulating the inflammatory response. Prostaglandin biology has potential clinical relevance for atherosclerosis, the response to vascular injury and aortic aneurysm.
- Published
- 2011
- Full Text
- View/download PDF
6. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice.
- Author
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Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ, Fitzgerald GA, and Samad TA
- Subjects
- Animals, Mice, Mice, Inbred C57BL, Mice, Knockout, Cyclooxygenase 2 physiology, Inflammation physiopathology, Neurons enzymology, Pain etiology, Spinal Cord enzymology
- Abstract
A cardinal feature of peripheral inflammation is pain. The most common way of managing inflammatory pain is to use nonsteroidal antiinflammatory agents (NSAIDs) that reduce prostanoid production, for example, selective inhibitors of COX2. Prostaglandins produced after induction of COX2 in immune cells in inflamed tissue contribute both to the inflammation itself and to pain hypersensitivity, acting on peripheral terminals of nociceptors. COX2 is also induced after peripheral inflammation in neurons in the CNS, where it aids in developing a central component of inflammatory pain hypersensitivity by increasing neuronal excitation and reducing inhibition. We engineered mice with conditional deletion of Cox2 in neurons and glial cells to determine the relative contribution of peripheral and central COX2 to inflammatory pain hypersensitivity. In these mice, basal nociceptive pain was unchanged, as was the extent of peripheral inflammation, inflammatory thermal pain hypersensitivity, and fever induced by lipopolysaccharide. By contrast, peripheral inflammation-induced COX2 expression in the spinal cord was reduced, and mechanical hypersensitivity after both peripheral soft tissue and periarticular inflammation was abolished. Mechanical pain is a major symptom of most inflammatory conditions, such as postoperative pain and arthritis, and induction of COX2 in neural cells in the CNS seems to contribute to this.
- Published
- 2009
- Full Text
- View/download PDF
7. F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases.
- Author
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Praticò D, Rokach J, Lawson J, and FitzGerald GA
- Subjects
- Alzheimer Disease metabolism, Animals, Arteriosclerosis metabolism, Disease Models, Animal, Humans, Risk Factors, Inflammation metabolism, Isoprostanes metabolism, Lipid Peroxidation
- Abstract
Isoprostanes are a new class of lipids, isomers of conventional enzymatically derived prostaglandins, which are produced in vivo primarily by a free radical-catalyzed peroxidation of polyunsaturated fatty acids. F2-isoprostanes, isomers of the enzyme-derived prostaglandin F2alpha, are the most studied species. Because of their mechanisms of formation, specific structural features that distinguish them from other free radical-generated products and chemical stability, they provide a reliable index of the oxidative component of several diseases in vivo. Consistent data suggest that formation of F2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress. Moreover, measurement of F2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants.
- Published
- 2004
- Full Text
- View/download PDF
8. Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2
- Author
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Elling, Roland, Robinson, Elektra K, Shapleigh, Barbara, Liapis, Stephen C, Covarrubias, Sergio, Katzman, Sol, Groff, Abigail F, Jiang, Zhaozhao, Agarwal, Shiuli, Motwani, Mona, Chan, Jennie, Sharma, Shruti, Hennessy, Elizabeth J, FitzGerald, Garret A, McManus, Michael T, Rinn, John L, Fitzgerald, Katherine A, and Carpenter, Susan
- Subjects
Biological Sciences ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Inflammatory and immune system ,Animals ,Cyclooxygenase 2 ,Enhancer Elements ,Genetic ,Gene Deletion ,Gene Expression Regulation ,HEK293 Cells ,Humans ,Immunity ,Lipopolysaccharides ,Lung ,Macrophages ,Mice ,Inbred C57BL ,Mice ,Knockout ,Models ,Genetic ,Mutation ,RNA ,RNA Splicing ,RNA ,Long Noncoding ,RNA ,Messenger ,Spleen ,Transcription ,Genetic ,CRISPR/Cas9 ,CRISPRi ,Ptgs2 ,inflammation ,innate immunity ,lincRNA-Cox2 ,Biochemistry and Cell Biology ,Medical Physiology ,Biological sciences - Abstract
An inducible gene expression program is a hallmark of the host inflammatory response. Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the magnitude, duration, and resolution of these responses. Among these is lincRNA-Cox2, a dynamically regulated gene that broadly controls immune gene expression. To evaluate the in vivo functions of this lincRNA, we characterized multiple models of lincRNA-Cox2-deficient mice. LincRNA-Cox2-deficient macrophages and murine tissues had altered expression of inflammatory genes. Transcriptomic studies from various tissues revealed that deletion of the lincRNA-Cox2 locus also strongly impaired the basal and inducible expression of the neighboring gene prostaglandin-endoperoxide synthase (Ptgs2), encoding cyclooxygenase-2, a key enzyme in the prostaglandin biosynthesis pathway. By utilizing different genetic manipulations in vitro and in vivo, we found that lincRNA-Cox2 functions through an enhancer RNA mechanism to regulate Ptgs2. More importantly, lincRNA-Cox2 also functions in trans, independently of Ptgs2, to regulate critical innate immune genes in vivo.
- Published
- 2018
9. Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1
- Author
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Curtis, Anne M., Fagundes, Caio T., Yang, Guangrui, Palsson-McDermott, Eva M., Wochal, Paulina, McGettrick, Anne F., Foley, Niamh H., Early, James O., Chen, Lihong, Zhang, Hanrui, Xue, Chenyi, Geiger, Sarah S., Hokamp, Karsten, Reilly, Muredach P., Coogan, Andrew N., Vigorito, Elena, FitzGerald, Garret A., and O’Neill, Luke A. J.
- Published
- 2015
10. Editorial: Streaming inflammation: From damage to healing and resilience–Volume II.
- Author
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Devchand, Pallavi R., Schadt, Eric E., and FitzGerald, Garret A.
- Subjects
INFLAMMATION ,DRUG target ,HEALING - Published
- 2023
- Full Text
- View/download PDF
11. Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.
- Author
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Lin, Nan, Shay, Jessica E. S., Xie, Hong, Lee, David S. M., Skuli, Nicolas, Tang, Qiaosi, Zhou, Zilu, Azzam, Andrew, Meng, Hu, Wang, Haichao, FitzGerald, Garret A., and Simon, M. Celeste
- Abstract
Colonic tissues in Inflammatory Bowel Disease (IBD) patients exhibit oxygen deprivation and activation of hypoxia-inducible factor 1α and 2α (HIF-1α and HIF-2α), which mediate cellular adaptation to hypoxic stress. Notably, macrophages and neutrophils accumulate preferentially in hypoxic regions of the inflamed colon, suggesting that myeloid cell functions in colitis are HIF-dependent. By depleting ARNT (the obligate heterodimeric binding partner for both HIFα subunits) in a murine model, we demonstrate here that myeloid HIF signaling promotes the resolution of acute colitis. Specifically, myeloid pan-HIF deficiency exacerbates infiltration of pro-inflammatory neutrophils and Ly6C
+ monocytic cells into diseased tissue. Myeloid HIF ablation also hinders macrophage functional conversion to a protective, pro-resolving phenotype, and elevates gut serum amyloid A levels during the resolution phase of colitis. Therefore, myeloid cell HIF signaling is required for efficient resolution of inflammatory damage in colitis, implicating serum amyloid A in this process. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
12. Genetic and pharmacological analysis of prostanoid receptor function
- Author
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Narumiya, Shuh and FitzGerald, Garret A.
- Subjects
Fever ,Prostaglandin Antagonists ,Placenta ,Receptors, Prostaglandin ,Receptors, Thromboxane ,Pain ,Mice ,GTP-Binding Proteins ,Ischemia ,Pregnancy ,Hypersensitivity ,Animals ,Humans ,Cyclooxygenase Inhibitors ,Bone Resorption ,Cell Nucleus ,Inflammation ,Mice, Knockout ,Aspirin ,Neovascularization, Pathologic ,Thromboxanes ,Biological Transport ,General Medicine ,Protein Structure, Tertiary ,Vasodilation ,Drug Design ,Perspective ,Colonic Neoplasms ,Prostaglandins ,Female ,Signal Transduction - Published
- 2001
13. Editorial: Streaming Inflammation: From Damage to Healing and Resilience.
- Author
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Devchand, Pallavi R., Schadt, Eric E., and FitzGerald, Garret A.
- Subjects
INFLAMMATION ,DRUG target - Published
- 2022
- Full Text
- View/download PDF
14. Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation.
- Author
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Winnik, Stephan, Lohmann, Christine, Richter, Eva K., Schäfer, Nicola, Song, Wen-Liang, Leiber, Florian, Mocharla, Pavani, Hofmann, Janin, Klingenberg, Roland, Borén, Jan, Becher, Burkhard, FitzGerald, Garret A., Lüscher, Thomas F., Matter, Christian M., and Beer, Jürg H.
- Abstract
Aims Epidemiological studies report an inverse association between plant-derived dietary α-linolenic acid (ALA) and cardiovascular events. However, little is known about the mechanism of this protection. We assessed the cellular and molecular mechanisms of dietary ALA (flaxseed) on atherosclerosis in a mouse model. Methods and results Eight-week-old male apolipoprotein E knockout (ApoE−/−) mice were fed a 0.21 % (w/w) cholesterol diet for 16 weeks containing either a high ALA [7.3 % (w/w); n = 10] or low ALA content [0.03 % (w/w); n = 10]. Bioavailability, chain elongation, and fatty acid metabolism were measured by gas chromatography of tissue lysates and urine. Plaques were assessed using immunohistochemistry. T cell proliferation was investigated in primary murine CD3-positive lymphocytes. T cell differentiation and activation was assessed by expression analyses of interferon-γ, interleukin-4, and tumour necrosis factor α (TNFα) using quantitative PCR and ELISA. Dietary ALA increased aortic tissue levels of ALA as well as of the n−3 long chain fatty acids (LC n−3 FA) eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid. The high ALA diet reduced plaque area by 50% and decreased plaque T cell content as well as expression of vascular cell adhesion molecule-1 and TNFα. Both dietary ALA and direct ALA exposure restricted T cell proliferation, differentiation, and inflammatory activity. Dietary ALA shifted prostaglandin and isoprostane formation towards 3-series compounds, potentially contributing to the atheroprotective effects of ALA. Conclusion Dietary ALA diminishes experimental atherogenesis and restricts T cell-driven inflammation, thus providing the proof-of-principle that plant-derived ALA may provide a valuable alternative to marine LC n−3 FA. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
- Full Text
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15. Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1
- Author
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Wang, Miao and FitzGerald, Garret A.
- Subjects
- *
CARDIOVASCULAR system , *SYNTHASES , *PROSTAGLANDINS E , *CYCLOOXYGENASE 2 inhibitors , *LABORATORY rodents , *NONSTEROIDAL anti-inflammatory agents , *INFLAMMATION , *ENZYME inhibitors , *ANIMAL experimentation , *BIOLOGICAL models , *CARDIOVASCULAR diseases , *COMPARATIVE studies , *DEGENERATION (Pathology) , *ENDOTHELIUM , *ENZYMES , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *EVALUATION research , *PHARMACODYNAMICS - Abstract
Both traditional and purpose-designed nonsteroidal anti-inflammatory drugs, selective for inhibition of cyclooxygenase (COX)-2, alleviate pain and inflammation but confer a cardiovascular hazard attributable to inhibition of COX-2–derived prostacyclin (PGI2). Deletion of microsomal PGE synthase-1 (mPGES-1), the dominant enzyme that converts the COX-derived intermediate product PGH2 to PGE2, modulates inflammatory pain in rodents. In contrast with COX-2 deletion or inhibition, PGI2 formation is augmented in mPGES-1−/− mice—an effect that may confer cardiovascular benefit but may undermine the analgesic potential of inhibitors of this enzyme. This review considers the cardiovascular biology of mPGES1 and the complex challenge of developing inhibitors of this enzyme. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
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16. Circadian control of lung inflammation in influenza infection.
- Author
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Sengupta, Shaon, Tang, Soon Y., Devine, Jill C., Anderson, Seán T., Nayak, Soumyashant, Zhang, Shirley L., Valenzuela, Alex, Fisher, Devin G., Grant, Gregory R., López, Carolina B., and FitzGerald, Garret A.
- Subjects
INFLUENZA ,INFLAMMATION ,CIRCADIAN rhythms ,BRONCHOALVEOLAR lavage ,MONOCYTES - Abstract
Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is essential for fighting infection, a balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance of diurnal variability in the timing of influenza infection is not well understood. Here we demonstrate that endogenous rhythms affect survival in influenza infection. Circadian control of influenza infection is mediated by enhanced inflammation as proven by increased cellularity in bronchoalveolar lavage (BAL), pulmonary transcriptomic profile and histology and is not attributable to viral burden. Better survival is associated with a time dependent preponderance of NK and NKT cells and lower proportion of inflammatory monocytes in the lung. Further, using a series of genetic mouse mutants, we elucidate cellular mechanisms underlying circadian gating of influenza infection. The circadian clock affects immune responses, but its role in influenza infection is not well understood. Here, Sengupta et al. show that time of infection and the circadian clock have no effect on lung virus titers, but affect inflammation, morbidity and mortality. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
17. Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation
- Author
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Winnik, Stephan, Lohmann, Christine, Richter, Eva K., Schäfer, Nicola, Song, Wen-Liang, Leiber, Florian, Mocharla, Pavani, Hofmann, Janin, Klingenberg, Roland, Borén, Jan, Becher, Burkhard, FitzGerald, Garret A., Lüscher, Thomas F., Matter, Christian M., and Beer, Jürg H.
- Subjects
Inflammation ,Polyunsaturated fatty acids ,α-Linolenic acid ,Atherosclerosis ,3. Good health - Abstract
European Heart Journal, 32 (20), ISSN:1522-9645, ISSN:0195-668X
18. Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment.
- Author
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Cox, Shannon L., O'Siorain, James R., Yan He, Lordan, Ronan, Naik, Amruta, Soon Yew Tang, Sengupta, Shaon, FitzGerald, Garret A., Carroll, Richard G., and Curtis, Annie M.
- Abstract
Fibroblasts are stromal cells abundant throughout tissues, including the lungs. Fibroblasts are integral coordinators of immune cell recruitment through chemokine secretion. Circadian rhythms direct the recruitment of immune cells to the lung, which in turn impacts response to infection and survival. Although fibroblasts display robust circadian rhythms, the contribution of the fibroblast molecular clock to lung-specific migration of immune cells and recruitment remains to be established. Mice challenged intranasally with lipopolysaccharide (LPS) at dusk showed increased expression of the pro-inflammatory cytokine IL-1ß and chemokine CXCL5 in the lung, which was accompanied by increased neutrophil recruitment. Primary lung fibroblasts with knockdown of the core clock gene Bmal1 and immortalized Bmal1-/- lung fibroblasts also displayed increased Cxcl5 expression under IL-1ß stimulation. Conditioned media obtained from IL-1ß- stimulated Bmal1-/- immortalized fibroblasts-induced greater neutrophil migration compared with Bmal1+/+ lung fibroblast controls. Phosphorylation of the NF-κB subunit, p65, was enhanced in IL-1ß- stimulated Bmal1-/- lung fibroblasts, and pharmacological inhibition of NF-κB attenuated the enhanced CXCL5 production and neutrophil recruitment observed in these cells. Collectively, these results demonstrate that Bmal1 represses NF-κB activity in lung fibroblasts to control chemokine expression and immune cell recruitment during an inflammatory response. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
19. The Coxibs, Selective Inhibitors of Cyclooxygenase-2.
- Author
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FitzGerald, Garret A. and Patrono, Carlo
- Subjects
- *
NONSTEROIDAL anti-inflammatory agents , *CYCLOOXYGENASES , *TREATMENT of arthritis , *HEADACHE treatment , *INDIGESTION , *SALICYLIC acid , *INDOMETHACIN , *INFLAMMATION - Abstract
The article provides information on nonsteroidal antiinflammatory drugs (NSAIDs). Although they are effective for the treatment of arthritis, menstrual pain and headache, the long-term use of NSAIDs is limited by gastrointestinal effects such as dyspepsia and abdominal pain and less often, gastric or duodenal perforation or bleeding. Three broad classes of cyclooxygenase inhibitors have emerged which include aspirin synthesized from salicylic acid, indomethacin and other NSAIDs, whose chemical modifications were based largely on findings in models of inflammation and gastric mucosal damage
- Published
- 2001
- Full Text
- View/download PDF
20. Nonsteroidal anti-inflammatory drugs and glucocorticoids in COVID-19.
- Author
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Ricciotti, Emanuela, Laudanski, Krzysztof, and FitzGerald, Garret A.
- Subjects
- *
COVID-19 , *ANTI-inflammatory agents , *COVID-19 treatment , *GLUCOCORTICOIDS , *SARS-CoV-2 , *VIRAL transmission - Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a wide spectrum of symptom severity, which is manifested at different phases of infection and demands different levels of care. Viral load, host innate-immune response to SARS-CoV-2, and comorbidities have a direct impact on the clinical outcomes of COVID-19 patients and determine the diverse disease trajectories. The initial SARS-CoV-2 penetrance and replication in the host causes death of infected cells, determining the viral response. SARS-CoV-2 replication in the host triggers the activation of host antiviral immune mechanisms, determining the inflammatory response. While a healthy immune response is essential to eliminate infected cells and prevent spread of the virus, a dysfunctional immune response can result in a cytokine storm and hyperinflammation, contributing to disease progression. Current therapies for COVID-19 target the virus and/or the host immune system and may be complicated in their efficacy by comorbidities. Here we review the evidence for use of two classes of anti-inflammatory drugs, glucocorticoids and nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of COVID-19. We consider the clinical evidence regarding the timing and efficacy of their use, their potential limitations, current recommendations and the prospect of future studies by these and related therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
21. F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases
- Author
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Praticò, Domenico, Rokach, Joshua, Lawson, John, and FitzGerald, Garret A.
- Subjects
- *
PROSTAGLANDINS , *PEROXIDATION , *LIPIDS , *NUCLEAR isomers - Abstract
Isoprostanes are a new class of lipids, isomers of conventional enzymatically derived prostaglandins, which are produced in vivo primarily by a free radical-catalyzed peroxidation of polyunsaturated fatty acids. F2-isoprostanes, isomers of the enzyme-derived prostaglandin F2α, are the most studied species. Because of their mechanisms of formation, specific structural features that distinguish them from other free radical-generated products and chemical stability, they provide a reliable index of the oxidative component of several diseases in vivo. Consistent data suggest that formation of F2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress. Moreover, measurement of F2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF
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