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4 results on '"Diaz, Ligia Esperanza"'

1. Association between dietary inflammatory index and inflammatory markers in the HELENA study.

Author

Shivappa N, Hebert JR, Marcos A, Diaz LE, Gomez S, Nova E, Michels N, Arouca A, González-Gil E, Frederic G, González-Gross M, Castillo MJ, Manios Y, Kersting M, Gunter MJ, De Henauw S, Antonios K, Widhalm K, Molnar D, Moreno L, and Huybrechts I

Subjects
Body Mass Index, C-Reactive Protein metabolism, Chronic Disease, Cytokines blood, Exercise, Fatty Acids adverse effects, Humans, Inflammation etiology, Linear Models, Risk Factors, Sugars adverse effects, Biomarkers blood, Diet, Inflammation blood
Abstract

Background: Previous research has shown that diet is associated with low-grade systemic inflammation among adults. However, no study has yet been conducted to explore the association between inflammatory potential of diet and low-grade systemic inflammation among adolescents whose dietary behavior may be different from adults., Methods and Results: We examine the predictive ability of 24-h recall-derived dietary inflammatory index (DII) scores on inflammation among 532 European adolescents in the HELENA cross-sectional study. The DII is a literature-derived dietary index developed to predict inflammation. The DII was calculated per 1000 calories and was tested against C-reactive protein, ILs-1,2,4,10, TNF-α, ICAM, vascular cell adhesion molecule (VCAM), and IFN-γ. All inflammatory markers had nonnormal distributions and therefore were log transformed. Analyses were performed using multivariable linear regression, adjusting for age, sex, city, BMI, smoking, and physical activity. Pro-inflammatory diet (higher DII scores) was associated with increased levels of various inflammatory markers: TNF-α, IL-1, 2, IFN-γ,  and vascular cell adhesion molecule (b DIIt3vs1 = 0.13, 95% CI: 0.001, 0.25; 0.13, 95% CI 0.001, 0.25; 0.40, 95% CI: 0.03, 0.77; 0.53, 95% CI: 0.05, 1.01; 0.07, 95% CI: 0.01, 0.13, respectively)., Conclusion: These results reinforce the fact that diet, as a whole, plays an important role in modifying inflammation in adolescents., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2017
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2. Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents: the HELENA Study.

Author

Martinez-Gomez D, Gomez-Martinez S, Ruiz JR, Diaz LE, Ortega FB, Widhalm K, Cuenca-Garcia M, Manios Y, De Vriendt T, Molnar D, Huybrechts I, Breidenassel C, Gottrand F, Plada M, Moreno S, Ferrari M, Moreno LA, Sjöström M, and Marcos A

Subjects
Actigraphy, Adolescent, Age Factors, Analysis of Variance, C-Reactive Protein analysis, Complement C3 analysis, Complement C4 analysis, Cross-Sectional Studies, Europe epidemiology, Female, Humans, Inflammation blood, Inflammation epidemiology, Inflammation immunology, Interleukin-6 blood, Male, Regression Analysis, Tumor Necrosis Factor-alpha blood, Inflammation prevention & control, Inflammation Mediators blood, Motor Activity, Physical Fitness, Self Report
Abstract

Objective: Atherogenesis involves an inflammatory process that occurs early in life even though clinical symptoms are not observed until adulthood. Two important protective factors for low-grade inflammation may be physical activity (PA) and fitness. We examined the independent associations of objective and subjective measurements of PA and fitness with low-grade inflammation in European adolescents., Methods: A total of 1045 adolescents, aged from 12.5 to 17.5 years old from 10 European cities, were selected from the HELENA-Cross-Sectional Study. Objectively-measured and self-reported PA variables were obtained by accelerometry and the International PA Questionnaire for Adolescents, respectively. Overall, cardiorespiratory, muscular and motor fitness variables were assessed by standardized field-based fitness tests and the International Fitness Scale. C-reactive protein (CRP), complement factors 3 (C3) and 4 (C4), interleukin-6 and TNF-α inflammatory markers were measured., Results: Objectively-measured vigorous PA was inversely associated with C3 (β=-0.094, P=0.021) but it did not remain significant after any objective fitness indicator was included in the model. Other objectively measured or self-reported assessments of PA were not significantly associated with inflammatory markers. All objective measures of fitness were inversely associated with CRP, C3 and C4, whereas only self-reported motor fitness remained significantly associated with C3, C4 and TNF-α. All these observations were independent of age, sex, city and body mass index or waist circumference., Conclusion: High PA in adolescence may play an indirect role on lessening low-grade inflammation through improvements in fitness., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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3. Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents: The HELENA Study

Author

Martinez Gomez, David, Gomez Martinez, Sonia, Ruiz, Jonatan R., Diaz, Ligia Esperanza, Ortega, Francisco B., Widhalm, Kurt, Cuenca Garcia, Magdalena, Manios, Yannis, De Vriendt, Tineke, Molnar, Denes, Huybrechts, Inge, Breidenassel, Christina, Gottrand, Frederic, Plada, Maria, Moreno, Sara, Ferrari, Marika, Moreno, Luis A., Sjöström, Michael, Marcos, Ascension, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Martinez Gomez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Garzón MJ, Sáinz ÁG, Porcel FB, Ruiz JR, Artero EG, Romero VE, Pavón DJ, Muñoz CS, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Donne CL, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Dietrich S, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Jiménez Pavón D, Albers U, Pedrero R, Meléndez A, Benito PJ, Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P, Moreno S., VITAGLIONE, PAOLA, Martinez Gomez, David, Gomez Martinez, Sonia, Ruiz, Jonatan R., Diaz, Ligia Esperanza, Ortega, Francisco B., Widhalm, Kurt, Cuenca Garcia, Magdalena, Manios, Yanni, De Vriendt, Tineke, Molnar, Dene, Huybrechts, Inge, Breidenassel, Christina, Gottrand, Frederic, Plada, Maria, Moreno, Sara, Ferrari, Marika, Moreno, Luis A., Sjöström, Michael, Marcos, Ascension, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Martinez Gomez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Garzón, Mj, Sáinz, Ág, Porcel, Fb, Ruiz, Jr, Artero, Eg, Romero, Ve, Pavón, Dj, Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Donne, Cl, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Jiménez Pavón, D, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, Navarro, P, and Moreno, S.

Subjects
Male, medicine.medical_specialty, Waist, Adolescent, Cross-sectional study, Physical fitness, Motor Activity, Regression Analysi, Internal medicine, medicine, Humans, Age Factor, Inflammation Mediator, Inflammation, Cross-Sectional Studie, Analysis of Variance, Physical activity, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Age Factors, Complement C4, Cardiorespiratory fitness, Actigraphy, Regression analysis, Physical fitne, Complement C3, Europe, Cross-Sectional Studies, C-Reactive Protein, Physical Fitness, Physical therapy, Regression Analysis, Female, Self Report, Analysis of variance, Inflammation Mediators, Cardiology and Cardiovascular Medicine, business, Body mass index, Human
Abstract

Objective: Atherogenesis involves an inflammatory process that occurs early in life even though clinical symptoms are not observed until adulthood. Two important protective factors for low-grade inflammation may be physical activity (PA) and fitness. We examined the independent associations of objective and subjective measurements of PA and fitness with low-grade inflammation in European adolescents. Methods: A total of 1045 adolescents, aged from 12.5 to 17.5 years old from 10 European cities, were selected from the HELENA-Cross-Sectional Study. Objectively-measured and self-reported PA variables were obtained by accelerometry and the International PA Questionnaire for Adolescents, respectively. Overall, cardiorespiratory, muscular and motor fitness variables were assessed by standardized field-based fitness tests and the International Fitness Scale. C-reactive protein (CRP), complement factors 3 (C3) and 4 (C4), interleukin-6 and TNF-α inflammatory markers were measured. Results: Objectively-measured vigorous PA was inversely associated with C3 (β= -0.094, P= 0.021) but it did not remain significant after any objective fitness indicator was included in the model. Other objectively measured or self-reported assessments of PA were not significantly associated with inflammatory markers. All objective measures of fitness were inversely associated with CRP, C3 and C4, whereas only self-reported motor fitness remained significantly associated with C3, C4 and TNF-α. All these observations were independent of age, sex, city and body mass index or waist circumference. Conclusion: High PA in adolescence may play an indirect role on lessening low-grade inflammation through improvements in fitness. © 2011 Elsevier Ireland Ltd.

Published
2012

4. Breastfeeding in Infancy Is Not Associated with Inflammatory Status in Healthy Adolescents.

Author

Vérier, Caroline M. P., Duhamel, Alain, Béghin, Laurent, Diaz, Ligia-Esperanza, Warnberg, Julia, Marcos, Ascensión, Gómez-Martínez, Sonia, Manios, Yannis, De Henauw, Stefaan, Sjöström, Michael, Moreno, Luis A., Kersting, Mathilde, Breidenassel, Christina, Molnar, Dènes, Artero, Enrique G., Ferrari, Marika, Widhalm, Kurt, DominiqueTurck, and Gottrand, Frédéric

Subjects
BREASTFEEDING, INFANTS, CARDIOVASCULAR diseases, INFLAMMATION, LIFESTYLES, NUTRITION, SERUM, CERULOPLASMIN, CELLULAR immunity, CELL adhesion
Abstract

It has been suggested that breast-feeding (BF) may be associated with a decreased risk of cardiovascular disease in adulthood. A low-grade inflammation is associated with an increased risk of cardiovascular disease, even in apparently healthy children. The objective of this study was to assess the potential modulating effect of BF on the inflammatory status of healthy adolescents. Information on BF (duration) was obtained from parental records in 484 of 1040 healthy European urban adolescents (56.4% females) that had a blood sample obtained as part of the Healthy Lifestyle in Europe by Nutrition and Adolescence study. Blood serum inflammatory markers were measured, including high sensitivity C-reactive protein, complement factors 3 and 4, ceruloplasmin, adhesion molecules (L-selectin and soluble endothelial selectin, soluble vascular cell adhesion molecule 1, and intercellular adhesion molecule 1), cytokines, TGFβ1, and white blood cells. After univariate analysis, a propensity score, including the potential confounding factors, was computed and used to assess the association between BF and selected inflammatory markers. BF was not significantly associated with any of the selected inflammatory markers after adjustment for gender and propensity score. In our study, BF was not associated with low-grade inflammatory status in healthy adolescents, suggesting that the potential cardiovascular benefits of BF are related to other mechanisms than modulation of inflammation or might become relevant at a later age. Groups at high risk for cardiovascular disease should be a target for further research concerning the effects of BF. [ABSTRACT FROM AUTHOR]

Published
2011
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