7 results on '"Cowie, Benjamin"'
Search Results
2. Epidemiology and phylogenetic analysis of hepatitis D virus infection in Australia.
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Jackson, Kathy, MacLachlan, Jennifer, Cowie, Benjamin, Locarnini, Stephen, Bowden, Scott, Karapanagiotidis, Theo, Nicholson, Suellen, Littlejohn, Margaret, and Higgins, Nasra
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INFECTIOUS disease transmission ,HEPATITIS D ,MEDICAL screening ,PHYLOGENY ,PUBLIC health surveillance ,RNA ,SEROLOGY ,VIRAL antibodies ,VIROLOGY ,DISEASE incidence ,DESCRIPTIVE statistics ,GENOTYPES - Abstract
Background: The incidence and trends of the hepatitis D virus (HDV) in Australia have not been recently assessed, and the circulating genotypes have never been determined. Aim: To characterise the current virology and epidemiology of HDV. Methods: Notifiable disease surveillance and laboratory testing data were analysed to assess demographics, risk factors and trends. HDV serology and RNA testing were performed on requested samples from 2010 to 2016. Sequencing of a 500‐nucleotide amplicon of the delta antigen and phylogenetic analysis of the strains from 2009 to 2016 were also conducted. Results: Ninety HDV notifications were reported to the Victorian Department of Health and Human Services between 2010 and 2016. The majority (64.4%) of those diagnosed were born overseas, most commonly in Sudan, Pakistan and Vietnam. Over the same period, 190 patients tested positive for anti‐HDV serology and 166 for HDV RNA. Sequencing of isolates from 169 individuals between 2009 and 2016 found that 80.5% strains were genotype 1, 16% genotype 5 and 3.5% genotype 2. Phylogenetic analysis confirmed the relatedness of strains from birth country, demonstrated the presence of the 'Pacific Island' genotype 1 strain in Queensland and supported possible transmission in correctional facilities and within families. Conclusions: This study demonstrates the ongoing need for routine HDV screening and engagement in clinical care for people living with HBV in Australia. Epidemiological findings highlight the diversity in those affected and provide insights into local and global geographic distribution and transmission patterns. [ABSTRACT FROM AUTHOR]
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- 2018
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3. Improving the identification of priority populations to increase hepatitis B testing rates, 2012.
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van Gemert, Caroline, Julie Wang, Simmons, Jody, Cowie, Benjamin, Boyle, Douglas, Stoove, Mark, Enright, Chris, Hellard, Margaret, and Wang, Julie
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POPULATION health ,DISEASE progression ,CHRONIC hepatitis B ,PREVENTION ,PATIENTS ,INFECTIOUS disease transmission ,HEPATOCELLULAR carcinoma ,LIVER tumors ,COMMUNITY health services administration ,HEPATITIS B vaccines ,IMMUNIZATION ,MEDICAL screening ,PREVENTIVE health services - Abstract
Background: It is estimated that over 40 % of the 218,000 people with chronic hepatitis B (CHB) in Australia in 2011 are undiagnosed. A disproportionate number of those with undiagnosed infection were born in the Asia-Pacific region. Undiagnosed CHB can lead to ongoing transmission and late diagnosis limits opportunities to prevent progression to hepatocellular carcinoma (HCC) and cirrhosis. Strategies are needed to increase testing for hepatitis B virus (HBV) (including culturally and linguistically diverse communities, Aboriginal and/or Torres Strait Islander (Indigenous) people and people who inject drugs). General practitioners (GPs) have a vital role in increasing HBV testing and the timely diagnosis CHB. This paper describes the impact of a GP-based screening intervention to improve CHB diagnosis among priority populations in Melbourne, Australia.Methods: A non-randomised, pre-post intervention study was conducted between 2012 and 2013 with three general practices in Melbourne, Australia. Using clinic electronic health records three priority populations known to be at increased CHB risk in Australia (1: Asian-born patients or patients of Asian ethnicity living in Australia; 2: Indigenous people; or 3): people with a history of injecting drugs were identified and their HBV status recorded. A random sample were then invited to attend their GP for HBV testing and/or vaccination. Baseline and follow-up electronic data collection identified patients that subsequently had a consultation and HBV screening test and/or vaccination.Results: From a total of 33,297 active patients, 2674 (8 %) were identified as a priority population at baseline; 2275 (85.1 %) of these patients had unknown HBV status from which 338 (14.0 %) were randomly sampled. One-fifth (n = 73, 21.6 %) of sampled patients subsequently had a GP consultation during the study period; only four people (5.5 %) were subsequently tested for HBV (CHB detected in n = 1) and none were vaccinated against HBV.Conclusion: CHB infection is an important long-term health issue in Australia and strategies to increase appropriate and timely testing are required. The study was effective at identifying whether Asian-born patients and patients of Asian had been tested or vaccinated for HBV; however the intervention was not effective at increasing HBV testing. [ABSTRACT FROM AUTHOR]- Published
- 2016
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4. Health literacy in patients with chronic hepatitis B attending a tertiary hospital in Melbourne: a questionnaire based survey.
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Dahl, Tanya F. M., Cowie, Benjamin C., Biggs, Beverley-Ann, Leder, Karin, MacLachlan, Jennifer H., and Marshall, Caroline
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CHRONIC hepatitis B , *HEALTH of immigrants , *HEALTH literacy , *PATIENTS , *INFECTIOUS disease transmission - Abstract
Background: Current estimates suggest over 218,000 individuals in Australia are chronically infected with hepatitis B virus. The majority of these people are migrants and refugees born in hepatitis B endemic countries, where attitudes towards health, levels of education, and English proficiency can be a barrier to accessing the Australian health care system, and best managing chronic hepatitis B. This study aimed to assess the knowledge of transmission and consequences of chronic hepatitis B among these patients. Method: A prospective study was conducted between May and August 2012. Patients with chronic hepatitis B were recruited from three Royal Melbourne Hospital outpatient clinics. Two questionnaires were administered. Questionnaire 1, completed during observation of a prospective participants' consultation, documented information given to the patient by their clinician. After the consultation, Questionnaire 2 was administered to assess patient demographics, and overall knowledge of the effect, transmission and treatment of hepatitis B. Results: 55 participants were recruited. 93% of them were born overseas, 17% used an interpreter, and the average time since diagnosis was 9.7 years. Results from Questionnaire 1 showed that the clinician rarely discussed many concepts. Questionnaire 2 exposed considerable gaps in hepatitis B knowledge. Few participants reported a risk of cirrhosis (11%) or liver cancer (18%). There was a high awareness of transmission routes, with 89% correctly identifying sexual transmission, 93% infected blood, and 85% perinatal transmission. However, 25% of participants believed hepatitis B could be spread by sharing food, and over 50% by kissing and via mosquitoes. A knowledge score out of 12 was assessed for each participant. The average score was 7.5. Multivariate analysis found higher knowledge scores among those with a family member also diagnosed with chronic hepatitis B and those routinely seeing the same clinician (p = 0.009 and p = 0.002, respectively). Conclusion: This is the largest Australian study assessing knowledge and understanding of the effect, transmission, and treatment of hepatitis B among chronically infected individuals. The findings highlight the knowledge gaps and misconceptions held by these patients, and the need to expand education and support initiatives. [ABSTRACT FROM AUTHOR]
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- 2014
5. BE AWARE -- HEPATITIS B AS AN STI.
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WHEELER, EMILY and COWIE, BENJAMIN
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HEPATITIS B transmission , *PREVENTION of sexually transmitted diseases , *VIRAL disease prevention , *CHRONIC diseases , *CONDOMS , *HEPATITIS B , *HEPATITIS B vaccines , *WORLD health , *SEXUAL partners , *INFECTIOUS disease transmission - Abstract
The article discusses the global prevalence of hepatitis B infections, reports on the dangers of the sexual transmission of hepatitis B and discusses the role that the hepatitis B vaccine and condom use can play in preventing the sexual transmission of hepatitis B.
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- 2011
6. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews.
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Nelson, Paul K., Mothers, Bradley M., Cowie, Benjamin, Hogan, Holly, Des Jorlois, Don, Horyniok, Danielle, and Degenhardt, Louisa
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VIRAL hepatitis , *INTRAVENOUS injections , *HEPATITIS B , *HEPATITIS C , *HEPATITIS viruses , *DRUG administration , *DISEASE risk factors , *INFECTIOUS disease transmission - Abstract
The article presents a study that investigates the risk factor for the transmission of viral hepatitis as well as the global prevalence of hepatitis B and hepatitis C in injecting drug users. It discusses the methods used in the study including study design and search strategy, data extraction and selection, and statistical analysis. It reveals that hepatitis B and hepatitis C viruses (HBV and HCV) increasingly occurs through unsafe drug injection.
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- 2011
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7. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study
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Mei Hsuan Lee, Maurizia Rossana Brunetto, Stefan Mauss, Sabahattin Kaymakoglu, CE Omuemu, Danjuma Adda, Philip Bruggmann, Beat Müllhaupt, Trân D Quang, Peter Jarcuska, Man-Fung Yuen, George V. Papatheodoridis, Rohani Jahis, Ding-Shinn Chen, Necati Örmeci, Christophe Moreno, Angelos Hatzakis, Antoine Abou Rached, Boris Lukšić, Thomas Berg, Renovat Ntagirabiri, Kathryn Razavi-Shearer, Sarah Blach, Gabriela Rjaskova, Samantha M Brandon, Jen Layden, Ohene Opare-Sem, Maria C Mendes Correa, Stefano Vella, Jan Sperl, Vincent Wai-Sun Wong, Hwai I. Yang, Stephen Oguche, Richard Njouom, Cielo Yaneth Rios, Yee Tak Hui, Behzad Hajarizadeh, Andy I. M. Hoepelman, Javier García-Samaniego, Ammal M. Metwally, Ivane Gamkrelidze, Julia A. Scott, Said A. Al-Busafi, Valentina Liakina, Zaigham Abbas, Olga Sagalova, Rifaat Safadi, Michael Manns, William Sievert, Seyed M Alavian, Kakharman Yesmembetov, Manal H El-Sayed, Juan Francisco Sánchez-Ávila, Wan-Long Chuang, Peter Stärkel, Ziv Ben-Ari, Chris Cunningham, Homie Razavi, Erkin Musabaev, Ulus Salih Akarca, Petr Urbánek, Gamal Shiha, Muhammed Aasim M Yusuf, Nina Weis, Hossein Poustchi, Ilias Gountas, E. A. Croes, Ayman Yosry, Reza Malekzadeh, Kostas Athanasakis, Agustín Albillos, Faleh Z. Al-Faleh, Christoph Sarrazin, Maria Buti, Arif Nawaz, Chung-Lin Yang, Kimberly Murphy, Adriana Vince, Aliya Konysbekova, Soek Siam Tan, Loreta A. Kondili, Mojca Matičič, Karolin Falconer, Hailemichael Desalegn, Alexander Nersesov, Ogu Omede, N. N. Pimenov, Nahum Méndez-Sánchez, Benjamin C Cowie, Helen Nde, Wai-cheung C Lao, Jordan Genov, Imam Waked, Joël Mossong, Ala I. Sharara, Henry Lik-Yuen Chan, Vivek A. Saraswat, Diego Alberto Cuellar, Devin Razavi-Shearer, Abraham O. Malu, Rui Tato Marinho, Huma Qureshi, Markus Cornberg, Faisal M. Sanai, Ching-kong K Loo, David Kershenobich, Pavol Kristian, Paulo R. Ferreira, Mel Krajden, Moon Seok Choi, Junko Tanaka, Faryal Al Lawati, Jonathan Schmelzer, Ann-Sofi Duberg, Jan Gerstoft, Lewis R. Roberts, Francesco Negro, Khalid Al Naamani, Wim Laleman, Solomon Obekpa, Henk W. Reesink, Tesia Shin, Richard Gray, Alnoor Ramji, Fadi H. Mourad, Abdul Rahman Bizri, Joop E. Arends, Shahin Merat, Krzysztof Tomasiewicz, Adkhamjon Mamatkulov, Jerzy Jaroszewicz, Peer Brehm Christensen, Adriaan J. van der Meer, Maheeba Abdulla, Frank Tacke, Cesar Yaghi, Pierre Van Damme, Christopher K Opio, Yasir Waheed, Joseph Woodring, Ponsiano Ocama, Zuridin Nurmatov, Bisi Bright, Van Thi Thuy Nguyen, Perttu Arkkila, Nick Walsh, Catherine A.M. Stedman, Mette Rye Clausen, Vladimir Chulanov, Antonio Craxì, Christophe Hézode, Abdulrahman Aljumah, Jeffrey V. Lazarus, Fuad Hasan, Sarah Robbins, Sona Frankova, Adrian Goldis, Rong-Nan Chien, Chris Estes, Stephen D. Ryder, Nguyen Thu Anh, Abate Bane, Muhammad S. Memon, Ken Pasini, Ivan Schréter, Sameer Alawadhi, Stuart K. Roberts, Steve S Egeonu, Anil C. Anand, Riina Salupere, Massimo Colombo, Giovanni Battista Gaeta, Maria Lucia Gomes Ferraz, Rosmawati Mohamed, Sylvia Drazilova, Hans Van Vlierberghe, Soo Aleman, Naveed Z. Janjua, Irena Hrstić, Manik Sharma, Carlos E Brandão Mello, Mario G. Pessoa, Berhane Redae, Mindie H. Nguyen, Petr Husa, Vana Sypsa, Samir Shah, Jacques E Mokhbat, Robert Flisiak, Carole Seguin-Devaux, Asad Chaudhry, Inka Aho, Sayed Himatt, Hamad I. Al-Ashgar, Young-Suk Lim, Stefan Zeuzem, University of Zurich, Polaris Observatory Collaborators, Polaris Observ Collaborators, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Experimental Immunology, Gastroenterology & Hepatology, Razavi-Shearer D, Gamkrelidze I, Nguyen MH, Chen DS, Van Damme P, Abbas Z, Abdulla M, Abou Rached A, Adda D, Aho I, Akarca U, Hasan F, Al Lawati F, Al Naamani K, Al-Ashgar HI, Alavian SM, Alawadhi S, Albillos A, Al-Busafi SA, Aleman S, Alfaleh FZ, Aljumah AA, Anand AC, Anh NT, Arends JE, Arkkila P, Athanasakis K, Bane A, Ben-Ari Z, Berg T, Bizri AR, Blach S, Brandão Mello CE, Brandon SM, Bright B, Bruggmann P, Brunetto M, Buti M, Chan HLY, Chaudhry A, Chien RN, Choi MS, Christensen PB, Chuang WL, Chulanov V, Clausen MR, Colombo M, Cornberg M, Cowie B, Craxi A, Croes EA, Cuellar DA, Cunningham C, Desalegn H, Drazilova S, Duberg AS, Egeonu SS, El-Sayed MH, Estes C, Falconer K, Ferraz MLG, Ferreira PR, Flisiak R, Frankova S, Gaeta GB, García-Samaniego J, Genov J, Gerstoft J, Goldis A, Gountas I, Gray R, Guimarães Pessôa M, Hajarizadeh B, Hatzakis A, Hézode C, Himatt SM, Hoepelman A, Hrstic I, Hui YT, Husa P, Jahis R, Janjua NZ, Jarčuška P, Jaroszewicz J, Kaymakoglu S, Kershenobich D, Kondili LA, Konysbekova A, Krajden M, Kristian P, Laleman W, Lao WC, Layden J, Lazarus JV, Lee MH, Liakina V, Lim YS, Loo CK, Lukšić B, Malekzadeh R, Malu AO, Mamatkulov A, Manns M, Marinho RT, Maticic M, Mauss S, Memon MS, Mendes Correa MC, Mendez-Sanchez N, Merat S, Metwally AM, Mohamed R, Mokhbat JE, Moreno C, Mossong J, Mourad FH, Müllhaupt B, Murphy K, Musabaev E, Nawaz A, Nde HM, Negro F, Nersesov A, Nguyen VTT, Njouom R, Ntagirabiri R, Nurmatov Z, Obekpa S, Ocama P, Oguche S, Omede O, Omuemu C, Opare-Sem O, Opio CK, Örmeci N, Papatheodoridis G, Pasini K, Pimenov N, Poustchi H, Quang TD, Qureshi H, Ramji A, Razavi-Shearer K, Redae B, Reesink HW, Rios CY, Rjaskova G, Robbins S, Roberts LR, Roberts SK, Ryder SD, Safadi R, Sagalova O, Salupere R, Sanai FM, Sanchez-Avila JF, Saraswat V, Sarrazin C, Schmelzer JD, Schréter I, Scott J, Seguin-Devaux C, Shah SR, Sharara AI, Sharma M, Shiha GE, Shin T, Sievert W, Sperl J, Stärkel P, Stedman C, Sypsa V, Tacke F, Tan SS, Tanaka J, Tomasiewicz K, Urbanek P, van der Meer AJ, Van Vlierberghe H, Vella S, Vince A, Waheed Y, Waked I, Walsh N, Weis N, Wong VW, Woodring J, Yaghi C, Yang HI, Yang CL, Yesmembetov K, Yosry A, Yuen MF, Yusuf MAM, Zeuzem S, Razavi H., Negro, Francesco, Razavi-Shearer, Devin, Gamkrelidze, Ivane, Nguyen, Mindie H, Chen, Ding-Shinn, Van Damme, Pierre, Abbas, Zaigham, Abdulla, Maheeba, Abou Rached, Antoine, Adda, Danjuma, Aho, Inka, Akarca, Ulu, Hasan, Fuad, Al Lawati, Faryal, Al Naamani, Khalid, Al-Ashgar, Hamad Ibrahim, Alavian, Seyed M, Alawadhi, Sameer, Albillos, Agustin, Al-Busafi, Said A, Aleman, Soo, Alfaleh, Faleh Z, Aljumah, Abdulrahman A, Anand, Anil C, Anh, Nguyen Thu, Arends, Joop E, Arkkila, Perttu, Athanasakis, Kosta, Bane, Abate, Ben-Ari, Ziv, Berg, Thoma, Bizri, Abdul R, Blach, Sarah, Brandão Mello, Carlos E, Brandon, Samantha M, Bright, Bisi, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Chan, Henry L Y, Chaudhry, Asad, Chien, Rong-Nan, Choi, Moon S, Christensen, Peer B, Chuang, Wan-Long, Chulanov, Vladimir, Clausen, Mette R, Colombo, Massimo, Cornberg, Marku, Cowie, Benjamin, Craxi, Antonio, Croes, Esther A, Cuellar, Diego Alberto, Cunningham, Chri, Desalegn, Hailemichael, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve S, El-Sayed, Manal H, Estes, Chri, Falconer, Karolin, Ferraz, Maria L G, Ferreira, Paulo R, Flisiak, Robert, Frankova, Sona, Gaeta, Giovanni B, García-Samaniego, Javier, Genov, Jordan, Gerstoft, Jan, Goldis, Adrian, Gountas, Ilia, Gray, Richard, Guimarães Pessôa, Mário, Hajarizadeh, Behzad, Hatzakis, Angelo, Hézode, Christophe, Himatt, Sayed M, Hoepelman, Andy, Hrstic, Irena, Hui, Yee-Tak T, Husa, Petr, Jahis, Rohani, Janjua, Naveed Z, Jarčuška, Peter, Jaroszewicz, Jerzy, Kaymakoglu, Sabahattin, Kershenobich, David, Kondili, Loreta A, Konysbekova, Aliya, Krajden, Mel, Kristian, Pavol, Laleman, Wim, Lao, Wai-cheung C, Layden, Jen, Lazarus, Jeffrey V, Lee, Mei-Hsuan, Liakina, Valentina, Lim, Young-Suk S, Loo, Ching-kong K, Lukšić, Bori, Malekzadeh, Reza, Malu, Abraham O, Mamatkulov, Adkhamjon, Manns, Michael, Marinho, Rui T, Maticic, Mojca, Mauss, Stefan, Memon, Muhammad S, Mendes Correa, Maria C, Mendez-Sanchez, Nahum, Merat, Shahin, Metwally, Ammal M, Mohamed, Rosmawati, Mokhbat, Jacques E, Moreno, Christophe, Mossong, Joel, Mourad, Fadi H, Müllhaupt, Beat, Murphy, Kimberly, Musabaev, Erkin, Nawaz, Arif, Nde, Helen M, Nersesov, Alexander, Nguyen, Van Thi Thuy, Njouom, Richard, Ntagirabiri, Renovat, Nurmatov, Zuridin, Obekpa, Solomon, Ocama, Ponsiano, Oguche, Stephen, Omede, Ogu, Omuemu, Casimir, Opare-Sem, Ohene, Opio, Christopher K, Örmeci, Necati, Papatheodoridis, George, Pasini, Ken, Pimenov, Nikolay, Poustchi, Hossein, Quang, Trân D, Qureshi, Huma, Ramji, Alnoor, Razavi-Shearer, Kathryn, Redae, Berhane, Reesink, Henk W, Rios, Cielo Yaneth, Rjaskova, Gabriela, Robbins, Sarah, Roberts, Lewis R, Roberts, Stuart K, Ryder, Stephen D, Safadi, Rifaat, Sagalova, Olga, Salupere, Riina, Sanai, Faisal M, Sanchez-Avila, Juan F, Saraswat, Vivek, Sarrazin, Christoph, Schmelzer, Jonathan D, Schréter, Ivan, Scott, Julia, Seguin-Devaux, Carole, Shah, Samir R, Sharara, Ala I, Sharma, Manik, Shiha, Gamal E, Shin, Tesia, Sievert, William, Sperl, Jan, Stärkel, Peter, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek S, Tanaka, Junko, Tomasiewicz, Krzysztof, Urbanek, Petr, van der Meer, Adriaan J, Van Vlierberghe, Han, Vella, Stefano, Vince, Adriana, Waheed, Yasir, Waked, Imam, Walsh, Nichola, Weis, Nina, Wong, Vincent W, Woodring, Joseph, Yaghi, Cesar, Yang, Hwai-I, Yang, Chung-Lin, Yesmembetov, Kakharman, Yosry, Ayman, Yuen, Man-Fung, Yusuf, Muhammed Aasim M, Zeuzem, Stefan, and Razavi, Homie
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0301 basic medicine ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,HBsAg ,Pediatrics ,Delphi Technique ,Infectious Disease Transmission ,CHRONIC HBV INFECTION ,NATURAL-HISTORY ,FOLLOW-UP ,HBSAG ,CARRIERS ,AGE ,COUNTRIES ,DISEASE ,ANTIGEN ,COHORT ,ddc:616.07 ,Global Health ,medicine.disease_cause ,0302 clinical medicine ,Prevalence ,HBV ,Child ,ddc:616 ,Antiviral Agents/therapeutic use ,education.field_of_study ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,Chronic/drug therapy/epidemiology/prevention & control/transmission ,Gastroenterology ,Hepatitis B Surface Antigens/blood ,Hepatitis B ,10219 Clinic for Gastroenterology and Hepatology ,Child, Preschool ,030211 gastroenterology & hepatology ,Viral hepatitis ,Viral load ,Adult ,medicine.medical_specialty ,Hepatitis B vaccine ,Population ,610 Medicine & health ,Antiviral Agents ,Mass Vaccination ,Hepatology ,03 medical and health sciences ,Hepatitis B, Chronic ,SDG 3 - Good Health and Well-being ,medicine ,Humans ,2715 Gastroenterology ,Preschool ,education ,Disease burden ,Hepatitis B virus ,Hepatitis B Surface Antigens ,business.industry ,Viral Vaccines ,medicine.disease ,Infectious Disease Transmission, Vertical ,Vertical/prevention & control ,030104 developmental biology ,2721 Hepatology ,Human medicine ,business - Abstract
PubMed: 29599078, 2-s2.0-85044540918, Background: The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus (HBV) infection, existing therapies to control viral replication and prophylaxis to minimise mother-to-child transmission make elimination of HBV feasible. We aimed to estimate the national, regional, and global prevalence of HBsAg in the general population and in the population aged 5 years in 2016, as well as coverage of prophylaxis, diagnosis, and treatment. Methods: In this modelling study, we used a Delphi process that included a literature review in PubMed and Embase, followed by interviews with experts, to quantify the historical epidemiology of HBV infection. We then used a dynamic HBV transmission and progression model to estimate the country-level and regional-level prevalence of HBsAg in 2016 and the effect of prophylaxis and treatment on disease burden. Findings: We developed models for 120 countries, 78 of which were populated with data approved by experts. Using these models, we estimated that the global prevalence of HBsAg in 2016 was 3·9% (95% uncertainty interval [UI] 3·4–4·6), corresponding to 291 992 000 (251 513 000–341 114 000) infections. Of these infections, around 29 million (10%) were diagnosed, and only 4·8 million (5%) of 94 million individuals eligible for treatment actually received antiviral therapy. Around 1·8 (1·6–2·2) million infections were in children aged 5 years, with a prevalence of 1·4% (1·2–1·6). We estimated that 87% of infants had received the three-dose HBV vaccination in the first year of life, 46% had received timely birth-dose vaccination, and 13% had received hepatitis B immunoglobulin along with the full vaccination regimen. Less than 1% of mothers with a high viral load had received antiviral therapy to reduce mother-to-child transmission. Interpretation: Our estimate of HBV prevalence in 2016 differs from previous studies, potentially because we took into account the effect of infant prophylaxis and early childhood vaccination, as well as changing prevalence over time. Although some regions are well on their way to meeting prophylaxis and prevalence targets, all regions must substantially scale-up access to diagnosis and treatment to meet the global targets. Funding: John C Martin Foundation. © 2018 Elsevier Ltd, H28-kansei-ippan-001 National Academy of Sciences, NAS Novartis Roche World Health Organization, WHO Gilead Sciences Alnylam Pharmaceuticals AbbVie Meso Scale Diagnostics, MSD British Microcirculation Society, BMS Japan Society for the Promotion of Science, JSPS: 17H03589 Ministry of Health, Labour and Welfare, MHLW Vetenskapsrådet, VR Siemens Universiteit Antwerpen OLL-683801, DR-S, IGa, SB, SMB, CE, KM, HMN, KP, KR-S, SR, JDS, and HR report grants from John C Martin Foundation, during the conduct of the study, and grants from Gilead Sciences, AbbVie, WHO, National Academy of Sciences, Intercept Pharmaceuticals, and Boehringer Ingelheim, outside the submitted work. MHN reports grants and personal fees from Bristol-Myers Squibb (BMS), Gilead Sciences, and Janssen, and personal fees from Novartis, Anylam, and Dynavax, outside the submitted work. PVD acts as chief and principal investigator for vaccine trials done on behalf of the University of Antwerp, Belgium, for which the University obtains research grants from vaccine manufacturers; speaker's fees for presentations on vaccines are paid directly to an educational fund held by the University of Antwerp, and PVD receives no personal remuneration for this work. ACA reports personal fees from Mylan Pharmaceuticals, outside the submitted work. JEA reports fees paid to his hospital for participation on the advisory boards of Gilead Sciences, ViiV Healthcare, BMS, Janssen, and AbbVie, and grants from BMS, Merck Sharp & Dohme (MSD), AbbVie, and ViiV Healthcare, outside the submitted work. TB reports grants, personal fees, and non-financial support from AbbVie and Gilead Sciences; grants and personal fees from BMS, Janssen, Roche, MSD, and Sequana Medical; and personal fees from Bayer, Vertex, Tibotec, Intercept, Sirtex, and Alexion, outside the submitted work. PB reports grants and personal fees from AbbVie, Gilead Sciences, and MSD, outside the submitted work. MBr reports personal fees from BMS, Gilead Sciences, and Janssen, and grants from BMS, outside the submitted work. HLYC reports personal fees from Gilead Sciences, BMS, AbbVie, Roche, MedImmune, and Intellia, outside the submitted work. PBC reports grants from AbbVie, Gilead Sciences, and MSD, outside the submitted work. VC reports personal fees from AbbVie, BMS, Gilead Sciences, and MSD, and grants from BMS, outside the submitted work. MCor reports personal fees from AbbVie, BMS, Boehringer Ingelheim, Biogen Idec, Falk Foundation, Gilead Sciences, Janssen, MSD, Roche Diagnostics, Roche Pharma, and Siemens, outside the submitted work. SD and PJ report personal fees and non-financial support from AbbVie and Gilead Sciences, and personal fees from MSD, outside the submitted work. MHE-S is an advisory board member for Perspectum Diagnostics, and reports grants and non-financial support from Gilead Sciences, and non-financial support from AbbVie and Quadri Pharma, outside the submitted work. RF reports grants, personal fees, and non-financial support from Roche and Gilead Sciences, and personal fees and non-financial support from BMS, outside the submitted work. GBG reports grants and personal fees from Gilead Sciences, outside the submitted work. JG-S reports grants and personal fees from Gilead Sciences, and personal fees from MSD, Abbvie, Janssen, and BMS, outside the submitted work. JGer reports grants and personal fees from AbbVie, Gilead Sciences, Janssen, MSD, BMS, and ViiV Healthcare, outside the submitted work. RG reports grants from New South Wales Ministry of Health and provided project advice regarding viral hepatitis treatment to Gilead Sciences, outside the submitted work. AHa reports unrestricted grants from AbbVie, MSD, Gilead Sciences, BMS, and Novartis, and non-financial support from Gilead Sciences, outside the submitted work; he was also on advisory boards for AbbVie, Gilead Sciences, and BMS. CH reports personal fees from AbbVie, BMS, Gilead Sciences, Janssen, and MSD, outside the submitted work. JJ reports personal fees and non-financial support from Gilead Sciences and AbbVie, and personal fees from Roche and BMS, outside the submitted work. MK reports grants from Roche, Siemens, Hologic, and Boerhinger Ingleheim, outside the submitted work. JVL reports grants and personal fees from Gilead Sciences and personal fees from Cepheid, outside the submitted work. MMan reports personal fees from Roche, BMS, GlaxoSmithKline, Aevi Genomic Medicine, ENYO Pharma, and CureVac, and grants and personal fees from Gilead Sciences and Novartis, outside the submitted work. SMau reports personal fees and non-financial support from Gilead Sciences and BMS, outside the submitted work. CM reports grants and personal fees from AbbVie, Gilead Sciences, and BMS; personal fees from MSD; and grants from Roche, outside the submitted work. BM reports grants and personal fees from Gilead Sciences and personal fees from AbbVie, MSD, BMS, Bayer, Intercept, and Sigma-Tau, during the conduct of the study. FN reports personal fees and non-financial support from Gilead Sciences, during the conduct of the study. AR reports grants and personal fees from AbbVie, Gilead, and MSD, and personal fees form BMS, Celgene, Janssen, Intercept, and Lupin, outside the submitted work. HWR reports grants and personal fees from AbbVie, BMS, Boehringer Ingelheim, ENYO Pharma, Gilead Sciences, Janssen, MSD, PRA Health Sciences, Regulus, and Roche; personal fees from Alnylam and R-Pharm; and grants from Replicor, outside the submitted work. LRR reports grants from the Center for Clinical and Translational Science and the Swedish Research Council (Ghana), during the conduct of the study. LRR also reports grants from Gilead Sciences, BTG, Ariad, and Wako, outside the submitted work, and was a consultant and advisory board member for Wako, Medscape, Axis, OncLive, Bayer, Tavec, and Grail. SDR has served as an advisory board member and speaker for Gilead Sciences, AbbVie, and MSD. OS has served as a consultant and on advisory boards for MSD; received research grants from AbbVie, BMS, MSD, Boehringer Ingelheim, R-Pharm, and Hepatera; and served as a speaker for Abbott, AbbVie, BMS, Gilead Sciences, Janssen, MSD, and R-Pharm. JFS-A reports personal fees from AbbVie and grants from Gilead Sciences and Janssen, outside the submitted work. CSa reports personal fees from Gilead Sciences and BMS, outside the submitted work. PS reports grants and personal fees from Gilead Sciences, AbbVie, and BMS, and personal fees from Intercept, outside the submitted work. CSt has consulted with and served on advisory boards for Gilead Sciences, AbbVie, and MSD. VSy reports grants and personal fees from Gilead Sciences, personal fees and non-financial support from AbbVie, and personal fees from Janssen, outside the submitted work. KT reports grants and personal fees from AbbVie, Gilead Sciences, and BMS; personal fees from MSD and Alfa Wasserman; and grants from Janssen, outside the submitted work. AJvdM reports grants and personal fees from Gilead Sciences and personal fees from AbbVie, outside the submitted work. IW reports personal fees from AbbVie, Gilead Sciences, Janssen, Marcyrl, Mylan, Onxio, and Pharco, outside the submitted work. NW reports personal fees paid to her department from AbbVie, BMS, Gilead Sciences, and MSD, outside the submitted work. VWW reports personal fees from Gilead Sciences, BMS, and MSD, outside the submitted work. M-FY was a speaker or advisory board member for AbbVie, BMS, Gilead Sciences, Roche, GlaxoSmithKline, Fujirebio, Biocartis, and MSD, outside the submitted work. SZ reports consultancy and lecture fees from AbbVie, Gilead Sciences, and MSD, and consultancy fees from Intercept, outside the submitted work. All other authors declare no competing interests., This study was funded by the John C Martin Foundation through the Polaris Observatory. We thank the Research on Hepatitis group (H28-kansei-ippan-001 and H25-kanen-ippan-010; led by JT), funded by the Ministry of Health, Labour and Welfare of Japan, for their provision of country-level data for Japan, and Örebro County Council for providing ALF grants (OLL-683801) to A-SD, which allowed collection of country-level data for Sweden.
- Published
- 2018
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