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To evaluate the sero-response to measles component of the first measles, mumps and rubella MMR dose given at 12 months by measuring measles antibody before and one month after the vaccination.A follow-up study where, 57 children at the age of 12 months were recruited randomly from the Primary Health Care Centers in Qassim, Saudi Arabia using a multistage sampling techniques. Fieldwork was conducted from October until December 2006. Blood samples were collected to measure measles IgG antibody before, and one month after giving MMR using enzyme linked immunosorbent assay. Data were compared before and after vaccination using geometric mean titer GMT and seroconversion.In the 57 infants, positivity rate increased significantly from 3.5% (2/57) pre-vaccination to 100% one month after p=0.0001, and with a sero-conversion of 96.5% (55/57). Also, GMT increased significantly from 0.014-2.172 IU/ML, after vaccination p=0.0001.Sero conversion and GMT are significantly high after the first MMR given at 12 months and this is supported by the surveillance data in Qassim.

To evaluate immune protection against vaccine-preventable diseases targeted by the Expanded Program of Immunization in Saudi Arabia.The study was carried out from September 2001 to February 2002. Using multistage sampling techniques, samples were collected from 5 regions of Saudi Arabia and sent for laboratory assay from the following age groups; 50 samples at 12 months, 50 at 6 years, and 100 at 17 years. Sera were assayed for diphtheria, tetanus, and pertussis. Sero neutralization was used for anti-diphtheria antibody assay, while enzyme linked immunoassay was used for anti-tetanus, anti-filament hemoagglutination (anti-FHA), and anti-pertussis titer (anti-PT) antibody assay.This survey showed that 100% of children had protection levels (/=0.01 IU/ml) against diphtheria at one year, 100% at 6 years, and 93.7% at 17 years. For tetanus, 95.9% had protection levels (/=0.1 IU/ml) at one year, 100% at 6 years, and 98.9% at 17 years. The geometric mean titer (GMT) of anti-FHA is 22 at one year, 29 at 6 years, and 24 IU/ml at 17 years, while the GMT of anti-PT is 36 at one year, 18 at 6 years, and 11 IU/ml at 17 years.Children at one, 6, and 17 years are well protected against diphtheria, pertussis, and tetanus.

A serosurvey study to evaluate the proportion of children with antibodies against diseases targeted by the Expanded Program of Immunization in the Kingdom of Saudi Arabia.Using multistage sampling techniques, we collected samples and sent them for laboratory assay from the following age groups; 100 samples at 6 months, 12 months, 18 months, 6 years, 13 years, and 17 years. We conducted the study from September 2001 to February 2002. We assayed sera for measles, rubella, and mumps antibodies in the measles-mumps-rubella reference laboratory in Germany, using enzyme immunoassay and plaque neutralization (PN) as a backup test for equivocal and negative samples. We only carried out a backup test for measles samples.The age group of 6 months had the highest proportion with negative measles antibodies. After adding the backup test (PN), the proportions of children with protective measles antibody were; 64% at 6 months, 87% at 12 months, 91% at 18 months, 75% at 6 years, 96% at 13 years, and 98% at 17 years. Rubella antibody positivity rates (7 IU) were 28% at 6 months, 49% at 12 months, 97% at 18 months, 98% at 6 years, and 100% at 13 years. While positivity rates in mumps were 14% at 6 months, 29% at 12 months, 59% at 18 months, 64% at 6 years, and 75% at 13 years.The unexpected low proportion of children with protective level at 6 years, despite being vaccinated with 2 measle doses is an important phenomenon. This reflects the interference between the first and the second measles dose. The Ministry of Health decided to conduct a catch up campaign targeting 1st through 3rd grade primary schools, who did not catch the mass campaign conducted in 2000. Also, this supports the decision taken by the ministry to change the measles immunization schedule to MMR at 12 months and a second dose at 6 years of age.

To compare the national growth monitoring data with the National Centre for Health Statistics (NCHS) growth standards, which is currently used in the Kingdom of Saudi Arabia (KSA).A cross sectional study following World Health Organization criteria in determining sample size was adopted, whereby 24,000 children from 5 regions were selected to be the desired sample. One hundred and two Primary Health Care centers were also selected randomly from the 5 regions, from where the sample was drawn. A special questionnaire was designed for the data collection. A pilot study was carried out to test the study instruments. Weight, height and head circumference were measured by standard procedures. This data was compared with the National Centre for Health Statistics (NCHS) data.The total number of children examined was 23,821, 11,913 boys and 11,908 girls, they were drawn from 102 health centers selected randomly. Comparing different percentiles for Saudi and NCHS data, there was a significant difference between the Saudi and American children.In order to ensure a correct follow up for our children in KSA, the national figures are more appropriate to follow than the NCHS data.