1. Thrombocytopenia and neonatal outcomes among extremely premature infants exposed to maternal hypertension
- Author
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Joanne Delaney, Gabriela De Carvalho Nunes, Jessica Simoneau, Marc Beltempo, Isabelle Malhamé, Catherine Goudie, and Gabriel Altit
- Subjects
Platelet Count ,Infant, Newborn ,Infant ,Anemia ,Hematology ,Thrombocytopenia ,Oncology ,Pregnancy ,Infant, Extremely Premature ,Pediatrics, Perinatology and Child Health ,Hypertension ,Humans ,Female ,Retrospective Studies ,Cerebral Hemorrhage - Abstract
Hypertensive disorders of pregnancy (HDP) are associated with neonatal hematological disturbances, such as thrombocytopenia. The association of HDP to platelet counts in the context of extreme prematurity, to trends of platelet counts during neonatal hospitalization, and to frequency of platelet transfusions remain to be explored.Retrospective study of infants born at less than 29 weeks born between 2015 and 2019. Platelet counts were collected on initial complete blood count, at 2 weeks, 32 weeks post-menstrual age (PMA), 36 weeks PMA, and closest to discharge. We examined the association between HDP and platelet counts at each time point, frequency of platelet transfusions and intraventricular hemorrhage (IVH) grade 3 or more.Total 296 infants were included, 43 exposed to HDP. Infants exposed had lower platelet counts at each time point, as well as a higher prevalence of platelet less than 150 × 10Premature infants exposed to HDP have a higher prevalence of thrombocytopenia, increased frequency of platelet transfusion, and an altered trend in platelet counts during neonatal hospitalization.
- Published
- 2022