1. Oral vitamin A, E and D supplementation of pre-term newborns either breast-fed or formula-fed: a 3-month longitudinal study.
- Author
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Delvin EE, Salle BL, Claris O, Putet G, Hascoet JM, Desnoulez L, Messai S, and Lévy E
- Subjects
- Adult, Antioxidants metabolism, Breast Feeding, Chromatography, High Pressure Liquid, Dietary Supplements, Female, Humans, Infant, Infant Nutritional Physiological Phenomena, Infant, Newborn growth & development, Infant, Premature, Longitudinal Studies, Male, Prospective Studies, Radioimmunoassay, Vitamin A blood, Vitamin D blood, Vitamin E blood, Antioxidants administration & dosage, Infant Formula, Infant, Newborn blood, Milk, Human, Vitamin A administration & dosage, Vitamin D administration & dosage, Vitamin E administration & dosage
- Abstract
Background: In contrast to the studies of vitamin A and E status in children, adolescents and adults, information on preterm infants is scarce. In the present investigation we examined the vitamin A, D and E status of pre-term infants at birth, and verified whether, at 1 and 3 months, breast or formula feeding affected the plasma concentration of those vitamins while being supplemented with Uvesterol ADEC., Patients and Methods: In this prospective study, 2 groups of consecutively recruited preterm newborns fed either breast milk or formula received 3000 IU of vitamin A, 5 IU of vitamin E and 1000 IU of vitamin D daily. Vitamin A and E were measured by high performance liquid chromatography and spectrophotometry. 25-hydroxyvitamin D, a surrogate marker for vitamin D status, was measured by radioimmunoassay, and retinol binding-protein concentration was measured by immunonephelometry., Results: At birth, formula-fed and breast-milk fed infants had similar plasma concentrations of vitamin A (0.75 +/- 0.20 and 0.64 +/- 0.21 micromol/L, ns), 25-hydroxyvitamin D (34.4 +/- 25.6 and 47.5 +/- 26.7 nmol/L, ns) and vitamin E (9.5 +/- 3.2 and 8.4 +/- 3.3 micromol/L, ns). Vitamins A and E, and retinol binding-protein concentrations steadily increased with time in both groups of infants without attaining, at 3 months, values considered normal in term infants and in young children. At 3 months of age, concentrations of 25-hydroxyvitamin D reached values comparable to those observed in term infants., Conclusion: Plasma concentrations of vitamins A and E and of retinol binding-protein steadily increased during the the study without reaching full repletion values. At the conclusion of the study, the type of nutrition did not affect plasma vitamin concentrations.
- Published
- 2005
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