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6 results on '"Koklu E"'

1. Severe vitamin D deficiency among pregnant women and their newborns in Turkey.

Author

Parlak M, Kalay S, Kalay Z, Kirecci A, Guney O, and Koklu E

Subjects
Adult, Female, Humans, Pregnancy, Severity of Illness Index, Turkey epidemiology, Vitamin D blood, Vitamin D Deficiency blood, Young Adult, Infant, Newborn blood, Mothers statistics & numerical data, Vitamin D Deficiency epidemiology
Abstract

Objectives: Vitamin D deficiency is an important health problem in pregnant women and their infants in sunny countries. Low socio-economic status (LSES), covered dressing style, pregnancies in winter season and having dark skin are the major risk factors for vitamin D deficiency. The present study evaluated serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations in pregnant women and in their newborns and determined the risk factors in LSES cities in Turkey., Methods: Ninety-seven pregnant women and their newborns were included in the study between December 2012 and February 2013. All of the pregnant women had irregular follow-up or had received no antenatal care, were pregnant during summer, had presented to the hospital after 37 weeks of gestation (WG) and had received no vitamin D supplementation. A detailed history was obtained, which included mothers' age, number of births and dressing sytle. Maternal and cord blood samples were taken to measure 25(OH)D3 levels., Results: All of the pregnant women were predominantly LSES, had covered dressing style and none of them had received vit D3 supplementation during pregnancy. The mean serum 25(OH)D3 level and mean cord blood level of of 97 mothers were 4.97 ± 3.27 ng/ml and 4.29 ± 2.44 ng/ml, respectively. There was a strong positive correlation between maternal serum and umbilical cord 25(OH)D3 levels (r: 0.735, p < 0.05). Ninety-five mothers had serum 25(OH)D3 below 20 ng/ml and all cord blood serum 25(OH)D3 levels were below 20 ng/ml. Level of 25(OH)D3 was not correlated with mother age, WG or newborn weight. Serum 25(OH)D3 concentrations in primigravida and multigravida were 3.71 ± 1.88 and 5.2 ± 3.4 ng/ml, respectively, with a significant difference between them (p < 0.05)., Conclusion: Severe vitamin D deficiency is common in reproductive women and their newborns in LSES cities of Turkey. Covered dressing style, not receiving any vitamin D supplementation and primigravida women are at greatest risk. Vitamin D supplementation campaigns which should cover pregnant women and the newborn to prevent maternal and perinatal vitamin D deficiency should be implemented especially in risk areas.

Published
2015
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3. Intima-media thickness of the abdominal aorta of neonate with different gestational ages.

Author

Koklu E, Kurtoglu S, Akcakus M, Yikilmaz A, Coskun A, and Gunes T

Subjects
Adrenal Cortex Hormones therapeutic use, Adult, Aorta, Abdominal drug effects, Birth Weight, Blood Pressure physiology, Body Height, Female, Humans, Male, Maternal Age, Sex Factors, Tunica Intima drug effects, Tunica Media drug effects, Ultrasonography, Aorta, Abdominal diagnostic imaging, Gestational Age, Infant, Newborn, Tunica Intima diagnostic imaging, Tunica Media diagnostic imaging
Abstract

Purpose: To determine aortic intima-media thickness (aIMT) values in newborns with different gestational ages and to asses the effect of antenatal steroids on aIMT., Methods: Two hundred forty newborns from healthy mothers had their distal abdominal aIMT measured during abdominal sonographic examination. The neonates were divided into 4 groups (60 in each group) according to gestational age: group I (25-28 weeks), group II (29-32 weeks), group III (33-37 weeks), and group IV (38-42 weeks)., Results: The interobserver and intersubject intraclass correlation coefficient was 0.93 and 0.94, respectively. Mean aIMT was 0.316 mm, 0.335 mm, 0.348 mm, and 0.385 mm, respectively, in group I, II, III, and IV, increasing significantly with gestational age at birth (p < 0.0001). There was no apparent effect of antenatal steroid use on aIMT. Multivariate regression models for mean aIMT demonstrated a significant association with aortic lumen diameter (p < 0.0001)., Conclusion: Abdominal aIMT can be reproducibly measured in neonates and may be a useful tool for epidemiologic studies., ((c) 2007 Wiley Periodicals, Inc.)

Published
2007
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4. The relationship between birthweight, 25-hydroxyvitamin D concentrations and bone mineral status in neonates.

Author

Akcakus M, Koklu E, Budak N, Kula M, Kurtoglu S, and Koklu S

Subjects
Absorptiometry, Photon, Alkaline Phosphatase blood, Anthropometry, Calcium blood, Female, Gestational Age, Humans, Infant, Newborn blood, Infant, Small for Gestational Age blood, Infant, Small for Gestational Age physiology, Male, Phosphorus blood, Vitamin D blood, Birth Weight physiology, Bone Density physiology, Infant, Newborn physiology, Vitamin D analogs & derivatives
Abstract

Background: Calcium (Ca), phosphorus (P) and 25-hydroxyvitamin D (25-OHD) are the major micronutrients for fetal skeletal development., Aims: To compare whole body bone mineral density (WB BMD) and bone mineral content (WB BMC) in different birthweights of term neonates and to determine correlations of biological criteria of bone health between neonates and their mothers., Subjects and Methods: Serum Ca, P, alkaline phosphatase (ALP) and 25-OHD levels were measured in 30 small-for-gestational-age (SGA, group 1), 40 appropriate-for-gestational-age (AGA, group 2) and 30 large-for-gestational-age (LGA, group 3) neonates and their mothers in winter. WB BMD and WB BMC of neonates were estimated by dual-energy X-ray absorptiometry (DEXA) in the 1st 24 hrs after delivery., Results: Mean (SD) serum 25-OHD levels in the mothers [8.7 (3.0), 8.6 (3.0) and 7.7 (2.8) microg/L, respectively] and their infants [6.3 (2.5), 6.0 (2.2) and 5.7 (1.8) microg/L, respectively] in groups 1, 2 and 3 were similar. Compared with the mothers, the mean 25-OHD levels of the neonates in all groups were significantly lower (p<0.05), and they were highly correlated (r=0.755, p<0.05). Ninety-three per cent of the neonates and 82% of their mothers had 25-OHD levels <10 microg/L, the lowest limit of normal. Mean (SD) WB BMD and WB BMC were higher in LGA infants [0.442 (0.025) g/cm(2), 71.6 (9.0) g, p<0.01, p<0.001, respectively] but lower in SGA [0.381 (0.027) g/cm(2), 29.1 (9.1) g, p<0.001, p<0.001, respectively] than in AGA infants [0.426 (0.022) g/cm(2), 53.7 (9.6) g, respectively]. The percentage of WB BMC was lower in SGA than in AGA and LGA infants. WB BMC and WB BMD were positively correlated with birthweight (r=0.910, p<0.05) and gestational age (r=0.707, p<0.05) but not with serum 25-OHD., Conclusions: The neonates' bone indices increased significantly with gestational age and birthweight but this was not related to serum 25-OHD levels in the infants and their mothers.

Published
2006
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5. Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society

Author

Koc E, Demirel N, Bas AY, Ulubas Isik DAUID- ORCID: 0000-0001-9937-4624, Hirfanoglu IM, Tunc T, Sari FN, Karatekin G, Ozdemir R, Altunhan H, Cetinkaya M, Ozcan B, Ozkiraz S, Calkavur S, Tekgunduz KS, Tastekin A, Ozlu F, Mutlu Ozyurt B, Ozdemir A, Cetinkaya B, Demirelli Y, Koklu E, Celik U, Tarakci N, Armangil D, Okulu E, Narter F, Mutlu B, Mert MK, Bulbul A, Asker HS, Uygur O, Uslu IS, Ertugrul S, Aydemir C, Celik HT, Kucuktasci K, Arslan S, Ergin H, Zenciroglu A, Yurttutan S, Orman A, and Tuncer O

Subjects
Adult, Birth Weight, Female, Gestational Age, Humans, Infant, Newborn, Infant, Newborn, Diseases/*epidemiology, Infant, Very Low Birth Weight, Intensive Care Units, Neonatal, Male, Morbidity, Pregnancy, Pregnancy Outcome/*epidemiology, Prospective Studies, Turkey/epidemiology
Abstract

OBJECTIVE: To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. MATERIAL AND METHODS: A prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of ≤1500 g were collected for infants who survived. RESULTS: Data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137±245 g and 29±2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. CONCLUSION: The present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs.

Published
2019

6. Incidence and severity of retinopathy of prematurity in Turkey

Author

Bas, A.Y., Koc, E., Dilmen, U., Oguz, S.S., Ovali, F., Demirel, N., Zenciroglu, A., Tekin, N., Caner, I., Arslanoglu, S., Celik, Y., Öztürk, A., Cömert, S., Bulbul, A., Kultursay, N., Koklu, E., Duman, N., Koksal, N., Salihoglu, O., Coban, A., Demirel, G., Bolat, F., Gökalp, A., Satar, M., Ipek, M.S., Bas, E.K., Narli, N., Mutlu, M., Cetinkaya, M., Akman, I., Yigit, S., Narter, F., Sivasli, E., Ahrabi, A.F., Atalay, Y., Tanyeri, B., Arsan, S., Perk, Y., Ors, R., Tuncer, O., Ecevit, A., Oygur, N., Özdemir, Özmert Muhammet Ali, Hakan, N., Aliefendioglu, D., Acunas, B., Cetin, H., Ozek, E., Tunc, T., Turkmen, M., Aydemir, C., Takci, S., and Bas, A.Y., Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Etlik, Keciören, Ankara, 06010, Turkey -- Koc, E., Department of Neonatology, Gazi University, Faculty of Medicine, Ankara, Turkey -- Dilmen, U., Department of Neonatology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey -- Oguz, S.S., Department of Neonatology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey -- Ovali, F., Zeynep Kamil Maternity and Children's Education and Training Hospital, Istanbul, Turkey -- Demirel, N., Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Etlik, Keciören, Ankara, 06010, Turkey -- Zenciroglu, A., Dr Sami Ulus Maternity and Children's Hospital, Ankara, Turkey -- Tekin, N., Osmangazi University Faculty of Medicine, Eskisehir, Turkey -- Caner, I., Ataturk University Faculty of Medicine, Erzurum, Turkey -- Arslanoglu, S., Dr Behcet Uz Children's Hospital, Izmir, Turkey -- Celik, Y., Mersin University Faculty of Medicine, Mersin, Turkey -- Öztürk, A., Erciyes University Faculty of Medicine, Kayseri, Turkey -- Cömert, S., Suleymaniye Maternity, Research and Training Hospital, Istanbul, Turkey -- Bulbul, A., Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey -- Kultursay, N., Ege University Faculty of Medicine, Izmir, Turkey -- Koklu, E., Megapark Hospital, Kahramanmaras, Turkey -- Duman, N., Dokuz Eylul University Faculty of Medicine, Izmir, Turkey -- Koksal, N., Uludag University Faculty of Medicine, Bursa, Turkey -- Salihoglu, O., Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey -- Coban, A., Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey -- Demirel, G., Samsun Maternal and Child Health Hospital, Samsun, Turkey -- Bolat, F., Cumhuriyet University Faculty of Medicine, Sivas, Turkey -- Gökalp, A., Kocaeli University Faculty of Medicine, Kocaeli, Turkey -- Satar, M., Cukurova University Faculty of Medicine, Adana, Turkey -- Ipek, M.S., Diyarbakir Maternal and Child Health Hospital, Diyarbakir, Turkey -- Bas, E.K., Gaziantep Children's Hospital, Gaziantep, Turkey -- Narli, N., Metro Hospital, Adana, Turkey -- Mutlu, M., Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey -- Cetinkaya, M., Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey -- Akman, I., Bahcesehir University Faculty of Medicine, Goztepe Medical Park Hospital, Istanbul, Turkey -- Yigit, S., Hacettepe University Faculty of Medicine, Ankara, Turkey -- Narter, F., Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey -- Sivasli, E., Gaziantep University Faculty of Medicine, Gaziantep, Turkey -- Ahrabi, A.F., Eskisehir State Hospital, Eskisehir, Turkey -- Atalay, Y., Department of Neonatology, Gazi University, Faculty of Medicine, Ankara, Turkey -- Tanyeri, B., Bezmialem University Faculty of Medicine, Istanbul, Turkey -- Arsan, S., Ankara University Faculty of Medicine, Ankara, Turkey -- Perk, Y., Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey -- Ors, R., Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey -- Tuncer, O., Yuzuncu Yil University Faculty of Medicine, Van, Turkey -- Ecevit, A., Baskent University Faculty of Medicine, Ankara, Turkey -- Oygur, N., Akdeniz University Faculty of Medicine, Antalya, Turkey -- Ozdemir, O.M., Pamukkale University Faculty of Medicine, Denizli, Turkey -- Hakan, N., Erzurum Training and Research Hospital, Erzurum, Turkey -- Aliefendioglu, D., Kirikkale University Faculty of Medicine, Kirikkale, Turkey -- Acunas, B., Trakya University Faculty of Medicine, Edirne, Turkey -- Cetin, H., Suleyman Demirel University Faculty of Medicine, Isparta, Turkey -- Ozek, E., Marmara University Faculty of Medicine, Istanbul, Turkey -- Tunc, T., Gulhane Military Medical Academy, Ankara, Turkey -- Turkmen, M., Adnan Menderes University Faculty of Medicine, Aydin, Turkey -- Aydemir, C., Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey -- Takci, S., Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, genetic structures, Turkey, retrospective study, prevalence, Gestational Age, Review, Infant, Premature, Diseases, Severity of Illness Index, Turkey (republic), Neonatal Screening, newborn, Risk Factors, Humans, controlled study, Retinopathy of Prematurity, human, procedures, Retrospective Studies, newborn screening, Incidence, prematurity, Infant, Newborn, birth weight, clinical trial, low level laser therapy, infant, major clinical study, eye diseases, female, multicenter study, priority journal, risk factor, retrolental fibroplasia, disease severity, sense organs, newborn intensive care, Infant, Premature
Abstract

BMJ Publishing Group, Background: The purpose of this study was to estimate the current incidence of retinopathy of prematurity (ROP) and the need for treatment in preterm infants in Turkey. Methods: The study included preterm infants who had been screened for ROP between 2011 and 2013 in 49 neonatal intensive care units. Infants with birth weight (BW) ?1500 g or ?32 weeks' gestational age and those with BW >1500 g or >32 weeks' GA with an unstable clinical course were included. The incidence of any ROP or severe ROP and treatment modalities were determined. Results: The study population included 15 745 preterm infants: 11 803 (75%) with GA ?32 weeks, and 3942 (25%) with GA >32 weeks. Overall, 30% were found to have any stage of ROP, and 5% had severe ROP. Severe ROP was diagnosed in 8.2% of infants with BW ?1500 g and 0.6% of infants with BW >1500 g. Of all infants diagnosed with ROP, 16.5% needed laser photocoagulation, and 20 patients born at >32 weeks' GA required this treatment modality. Vitroretinal surgery was performed in 28 infants with severe ROP: 23 with GA ?28 weeks and 5 with GA 29-32 weeks. Conclusions: The findings of our study have the important implication that more mature babies are at risk of severe ROP requiring treatment. An effective programme for detecting and treating ROP should be established in Turkey., Bas, A.Y.; Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research HospitalTurkey

Published
2015

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