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Start Over Author "Vors JP" Topic indenes
2 results on '"Vors JP"'

1. Synthetic studies toward sordarin: building blocks for the terpenoid core and for analogues thereof.

Author

Schulé A, Liang H, Vors JP, and Ciufolini MA

Subjects
Carboxylic Acids chemistry, Cyclopentanes chemistry, Indenes chemistry, Nitriles chemistry, Oxygen chemistry, Protein Synthesis Inhibitors chemistry, Stereoisomerism, Indenes chemical synthesis, Protein Synthesis Inhibitors chemical synthesis, Terpenes chemistry
Abstract

Avenues to bi- and tricyclic building blocks for the elaboration of sordaricin and its analogues are described. The target molecules were obtained through inter- and intramolecular Diels-Alder reactions of a number of previously unknown cyclopentadienes. Unusual properties of 3-cyanoenones and 1-cyanocyclopentadienes have been unveiled and circumvented.

Published
2009
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2. An avenue to the sordarin core adaptable to analog synthesis.

Author

Liang H, Schulé A, Vors JP, and Ciufolini MA

Subjects
Antifungal Agents chemistry, Antifungal Agents pharmacology, Indenes chemistry, Indenes pharmacology, Molecular Structure, Structure-Activity Relationship, Terpenes chemical synthesis, Antifungal Agents chemical synthesis, Indenes chemical synthesis, Terpenes chemistry
Abstract

We describe a synthesis of ketones 3 (X = O-R or CN; Y = H or alkyl), which are useful building blocks for the preparation of analogs of the potent antifungal agent sordarin, 1. Congeners of 1 constructed from 3 should permit detailed SAR investigations of the terpenoid core of the natural product.

Published
2007
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