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Objectives We aimed to analyze in children suffering from chronic haemophilic arthropathy relation between there functional impact and there quality of life. Methods Twenty- three children (mean age of 10.9±3.5 years [4-18]) suffering from severe haemophilia (median disease duration of 12 months (6; 18),median diagnosis delay of 0 months (0, 7)) were included. Functional impairment and quality of life were respectively assessed by the Moroccan versions of Children Health Assessment Questionnaire (CHAQ) and the European Quality of Life (the EUROQOL). A statistical analysis was conducted to determine the correlation between these two parameters using the r of Spearman Results Chronic haemophilic arthropathy affected knee, elbow, ankle and wrist in respectively 50, 27.5, 20 and 2.5%. Median CHAQ was 0.37 (0, 1.25). EUROQOL domains were affected as following: Mobility (69.6%),usual activity (65.2%), self-care (65.2%), anxiety/depression (43.4%) and pain (34.7%) Table 1 summarize correlation between the CHAQ and the 5 domains of EUROQOL. Conclusions This study suggests that the functional impact of chronic haemophilic arthropathy in children affected by severe hemophilia seems mainly related to the domains of mobility, self-care and usual activity of the EUROQOL. Further studies are required to verify those results. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.4867

Background Polymorphisms in Vitamin D receptor (FokI (VDR-F) and BsmI (VDR-B)), Estrogen receptor (Pvu II (ESR1P) and Xba I (ESR1X)), Collagen type1 (SpI (COL1A1) and Calcitonin Receptor (Alu I (CTR)) are thought to be candidate markers for osteoporosis. Based on the fact that osteoporosis and periodontal diseases are bone destructive diseases, we investigated the relationship between polymorphisms in these candidate genes and bone mineral density (BMD) of lumbar spine and femoral neck in patients suffering from chronic periodontitis (CP). Methods Lumbar spine and femoral neck BMD of individuals included in this study were diagnosed using the dual X-ray absorptiometry method. Blood was drawn and Genomic DNA was prepared and genotyped using MetaBone Clinical Arrays kit (Genomica, Spain). The genotyping and polymorphisms identification consisted on the simultaneous amplification of five regions of the genome containing the six SNPs of interest. Clinical attachment level (CAL), gingival bleeding index (GI), and probing depth (PD) and Simplified Oral Hygiene Index (OHI-S) were determined in all participants by a single experimented examiner. Results Table 1 (below) shows SNPs and variant alleles prevalence of genes associated with metabolic bone disorders in 18 chronic periodontitis patients: Statistical analysis showed that women with CP carrying the genotype VDRF-FOKI (Ff) have a lower lombar BMD (p=0.003) and higher number of teeth loss (p=0.003). However, we were not able, in this preliminary study, to show any association between BMD of lumbar spine L2–L4 and Ward9s BMD in CP patients and polymorphisms in different geotyped genes; Vitamin D receptor BsmI (VDR-B), Estrogen receptor PvuII (ESR1P), Collagen type1 SpI (COL1A1) and Calcitonin Receptor Alui (CTR). Furthermore, no association was found between these polymorphisms and severity parameters of chronic periodontitis. Conclusions This preliminary study showed that Lower lombar BMD were observed in patients who carried VDRF-FOKI Ff genotype and lower prevalence of normal variants of VDRB-BSMI, CTR-ALUI and ESR1X-XBAI in the population of chronic periodontitis women. A larger case control study is ongoing in order to get bigger data to complete this report. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5961

Objectives Assessment of fatigue in Moroccan patients with rheumatoid arthritis (RA) and its relationship with disease parameters. Methods 1089 Moroccan patients with rheumatoid Arthritis (RA) were included in the multicenter cross-sectional study QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis). The presence of fatigue was researched and its degree was assessed by a visual analogue scale (VAS) ranging from 0 to 100 mm. The presence and intensity of fatigue were correlated to the RA patient and disease parameters (sex, DAS 28, score of Health assessment Questionnaire (HAQ), corticosteroids intake, presence or absence of sleep disorders or psychological problems). Results The mean age of our patients was 49 ± 12.6 years with a female predominance of 80.3%. The average of disease duration was 6 (3, 12) years. The mean DAS28 was 4.9 ± 1.68. The average of HAQ was 1 (0.4, 1.6). Fatigue was present in 97.1% patients and the average of VAS fatigue was 43.2 ± 26.6 mm. A high level of fatigue was associated with female gender (44% versus 39%, p = 0.05), an important level of disease activity (r = 0.544, p Conclusions Fatigue is a major problem in our patients with RA and must be included in their routine assessment. In our sample, fatigue appears to be related to female sex, high level of disease activity and greater functional disability. Disclosure of Interest None Declared

Background Regular physical activity is associated with decreased morbidity and mortality. Traditionally, patients with rheumatoid arthritis (RA) have been advised to limit physical exercise. Objectives to Assess the impact of rheumatoid arthritis on physical activity. Methods The Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) is a cross-sectional study that includes a self-report questionnaire and clinical assessment of non selected consecutive outpatients with RA who are receiving usual clinical care. Frequency of physical exercise (>or=30 minutes with at least some shortness of breath, sweating) is queried with 4 response options: >or=3 times weekly, 1-2 times weekly, 1-2 times monthly, and no exercise. Results The total of 1129 patients were enrolled: 87,3% were women, the mean age was 48 years, and the mean disease duration was 6 years. Only 2,8% of all patients reported physical exercise>or=3 times weekly. The majority of the patients were physically inactive with no regular weekly exercise: >80. Physical inactivity was associated with disease duration, higher levels of disease activity, pain, morning stiffness and fatigue. Conclusions This study provided the evidence that the physical inactivity rates remain high among people with RA during this millennium. The rheumatologist should motivate patients to increase physical activity levels. Disclosure of Interest None Declared