1. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice
- Author
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Izumi Ishikawa, Shizuo Akira, Yoshiyuki Goto, Shiori Shikata, Yosuke Kurashima, Morio Higuchi, Yuji Suzuki, Jun Kunisawa, Casandra Panea, Eri Hashimoto, So Tajiri, Ivaylo I. Ivanov, Taichi Wake, Hiroshi Kiyono, Kiyoshi Takeda, Lamichhane Aayam, Masashi Gohda, and Risa Sumiya
- Subjects
Immunoglobulin A ,Ovalbumin ,T cell ,Plasma Cells ,Administration, Oral ,General Physics and Astronomy ,Plasma cell ,Article ,General Biochemistry, Genetics and Molecular Biology ,Mice ,Peyer's Patches ,medicine ,Animals ,Cell Proliferation ,CD11b Antigen ,Multidisciplinary ,Bacteria ,biology ,Cell growth ,General Chemistry ,Molecular biology ,Interleukin-10 ,Intestines ,Interleukin 10 ,medicine.anatomical_structure ,Integrin alpha M ,Immunology ,biology.protein ,Immunization ,Antibody - Abstract
Intestinal plasma cells predominantly produce immunoglobulin (Ig) A, however, their functional diversity remains poorly characterized. Here we show that murine intestinal IgA plasma cells can be newly classified into two populations on the basis of CD11b expression, which cannot be discriminated by currently known criteria such as general plasma cell markers, B cell origin and T cell dependence. CD11b+ IgA+ plasma cells require the lymphoid structure of Peyer’s patches, produce more IgA than CD11b− IgA+ plasma cells, proliferate vigorously, and require microbial stimulation and IL-10 for their development and maintenance. These features allow CD11b+ IgA+ plasma cells to mediate early-phase antigen-specific intestinal IgA responses induced by oral immunization with protein antigen. These findings reveal the functional diversity of IgA+ plasma cells in the murine intestine., Intestinal plasma cells contribute to the delicate balance between immunity against pathogens and tolerance of intestinal microflora. Kunisawa et al. identify a subpopulation of plasma cells whose proliferation depends on stimulation by microbes and IL-10, and which mediate early-phase responses to oral antigens.
- Published
- 2013